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The protein encoded by TSHR is a membrane protein and a major controller of thyroid cell metabolism. Additionally we are shipping TSH receptor Kits (18) and TSH receptor Proteins (12) and many more products for this protein.
Showing 10 out of 292 products:
Human Monoclonal TSH receptor Primary Antibody for FACS, IHC (fro) - ABIN118959
Suh, Song, Kim, Kim, Chung, Hwang, Kim, Hwang, Chung, Han, Cho, Ro, Shong et al.: Regulation of the phosphatidylinositol 3-kinase, Akt/protein kinase B, FRAP/mammalian target of rapamycin, and ribosomal S6 kinase 1 signaling pathways by thyroid-stimulating hormone (TSH) and ... in The Journal of biological chemistry 2003
Show all 2 references for ABIN118959
Cow (Bovine) Polyclonal TSH receptor Primary Antibody for WB - ABIN2777037
Claus, Jaeschke, Kleinau, Neumann, Krause, Paschke: A hydrophobic cluster in the center of the third extracellular loop is important for thyrotropin receptor signaling. in Endocrinology 2005
Show all 2 references for ABIN2777037
Human Polyclonal TSH receptor Primary Antibody for IHC, ELISA - ABIN1585468
Burgos, Iresjö, Wärnåker, Smedh: Presence of TSH receptors in discrete areas of the hypothalamus and caudal brainstem with relevance for feeding controls-support for functional significance. in Brain research 2016
Human Monoclonal TSH receptor Primary Antibody for EIA, FACS - ABIN119039
Costagliola, Rodien, Many, Ludgate, Vassart: Genetic immunization against the human thyrotropin receptor causes thyroiditis and allows production of monoclonal antibodies recognizing the native receptor. in Journal of immunology (Baltimore, Md. : 1950) 1998
Functional thyroid differentiation in zebrafish was examined and the role of TSHR signaling during thyroid organogenesis, was characterized.
lncRNA PVT1 may contribute to tumorigenesis of thyroid cancer through recruiting EZH2 (show EZH2 Antibodies) and regulating TSHR expression.
experimentally verified contact of Ser (show SIGLEC1 Antibodies)-281 (ECD (show SHFM1 Antibodies)) and Ile-486 (TMD (show TTN Antibodies)) was subsequently utilized in docking homology models of the ECD (show SHFM1 Antibodies) and the TMD (show TTN Antibodies) to create a full-length model of a glycoprotein hormone receptor (show NR4A1 Antibodies)
TSHR gene polymorphisms are associated with typical symptoms in primary congenital hypothyroidism.
The eminent ratio of TSHr methylation in well-differentiated thyroid carcinoma against benign thyroidal nodules adduced that TSHr methylation status can be utilized as a tumor marker for well-differentiated thyroid cancer.
Thyroid-stimulating hormone receptor intronic polymorphisms are associated with the susceptibility to Graves' disease and Graves' ophthalmopathy in the Brazilian population, but do not appear to influence the disease course.
data support a structural model of the TSHR transmembrane domain with a bulged transmembrane helix TM2 (show TPM2 Antibodies) and a straight TM5 that is specific of glycoprotein hormone receptors
TSHR gene variants are associated with congenital hypothyroidism.
the hinge region and its adjacent domains have roles in binding and signaling patterns of the thyrotropin and follitropin receptor (show FSHR Antibodies)
subclinical hypothyroidism in heterozygotes with TSHR mutations is a stable compensated condition with an appropriately adjusted set point for pituitary-thyroid feedback that does not require replacement therapy
Patients with preoperative TSHR-mRNA >/=1.02 ng/mug may be at a greater risk for recurrence of thyroid cancer.
Data indicate that splenic T cells from thyroid stimulating hormone receptor (TSHR) A-subunit primed animals undergoing Graves' orbitopathy (GO) showed proliferative responses to purified TSHR antigen and secreted proinflammatory cytokines.
Lung fibroblasts of TSHR KO mice have decreased cell surface Igf1r (show IGF1R Antibodies) expression, and have Igf1r (show IGF1R Antibodies) protein and protein fragments in both cytoplasm and nucleus. Igf1r (show IGF1R Antibodies) mRNA levels were similar between TSHR KO and WT mice.
The mechanism, underlying TSH-induced liver triglyceride accumulation, involved that TSH, through its receptor TSHR, triggered hepatic SREBP-1c (show SREBF1 Antibodies) activity.
These findings suggest that activation of TSHR directly inhibits FASN (show FASN Antibodies) expression in mature adipocytes, possibly mediated by PKA and ERK (show EPHB2 Antibodies)
A novel role for TSHR in behavioral and neurological phenotypes of Attention deficit/hyperactivity disorder.
The data indicate functional TSHR is expressed in ventricular myocytes and mediates TSH-induced BNP (show BNC2 Antibodies) secretion and HMGCR (show HMGCR Antibodies) up-regulation through the cAMP/PKA/pCREB signaling pathway.
findings demonstrate TSH-R expression is thymus-specific within the immune system; data support the notion of a novel neuroendocrine-immune interaction in which TSH-R signaling in the thymus, most likely mediated by TSH, enhances thymic T-cell development
The inhibition of hepatic PEPCK (show PEPCK Antibodies) and G6P and enhanced expression of GK contributed to the development of fasting hypoglycemia in Tshr-ko mice.
UCP-1 (show UCP1 Antibodies) and TSHR co-localized in retrobulbar adipose tissues in murine models of Graves' disease.
Cloned a thyroid-stimulating hormone receptor (TSHR) cDNA from thyroid glands. The sequence of this cDNA indicated that it encoded a 739 amino acid TSHR splice variant that lacked exon 5 (TSHR739).
Localization of thyrotropin receptor and thyroglobulin (show TG Antibodies) in the bovine corpus luteum.
analysis of activation switch in the thyrotropin receptor
Rhes (show RASD2 Antibodies) can interfere with the functional activity of wt and mutated TSHr.
Increased receptor binding by bovine (b) TSH bound to monoclonal antibody to bTSHbeta-subunit.
the hinge region represents an extracellular intermediate connector for both hormone binding and signal transduction of the thyroid stimulating hormone receptor
The equine TSHR is not responsive to equine chorionic gonadotropin but is more sensitive to human CG than the human TSHR
The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene.
, thyroid-stimulating hormone receptor
, thyrotropin receptor
, seven transmembrane helix receptor
, thyrotropin receptor-I, hTSHR-I