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TJP2 encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. Additionally we are shipping TJP2 Antibodies (104) and TJP2 Kits (6) and many more products for this protein.
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Data identified two Disease-causing Genes TJP2 and GJB2 (show GJB2 Proteins) in a Chinese Family with Unconditional Autosomal Dominant Nonsyndromic Hereditary Hearing Impairment.
TJP2 deficiency may predispose to hepatocellular carcinoma in early childhood
Claudin-19 (show CLDN19 Proteins), the most abundant claudin in myelin, exhibited no binding to ZO2.
JAM-A (show F11R Proteins) regulates epithelial permeability via association with ZO-2, afadin, and PDZ-GEF1 (show RAPGEF2 Proteins) to activate Rap2c (show RAP2C Proteins) and control contraction of the apical cytoskeleton.
Protein-truncating mutations in the tight junction protein 2 gene cause failure of protein localization and disruption of tight-junction structure, leading to severe cholestatic liver disease.
demonstrated that ZO-2 inhibition increases invasive and migrative capacities of invasive tumor cells. This was associated with an increase of MT1-MMP (show MMP14 Proteins)
the Alu-related transcript of TJP2 gene (TJP2-Alu transcript) was differentially expressed between colorectal tumor and normal tissues; potential diagnostic markers for colorectal cancer.
ZO-2 inhibits the Wnt (show WNT2 Proteins) signaling pathway, reduces cell proliferation, and promotes apoptosis; its absence, mutation, or overexpression is present in various human diseases, including deafness and cancer.
AmotL1 and ZO-2 are two candidates that could be harnessed to control the oncogenic function of YAP (show YAP1 Proteins).
these findings imply involvement of the ZO-2 tight junction independent signaling complex containing Jak1 (show JAK1 Proteins) and uPAR (show PLAUR Proteins) in VSMC intercellular communications.
Expression of Podocalyxin (show PODXL Proteins), which positively regulates the formation of microvilli and the apical membrane, is repressed in embryoid bodies lacking both ZO-1 (show TJP1 Proteins) and ZO-2 and this correlates with an aberrant submembranous localization of Ezrin (show EZR Proteins).
SNX27 (show SNX27 Proteins) associates with ZO-2 and modulates the epithelial tight junction.
ZO-2 protects against podocyte dysfunction induced by adreiamycin. This action is regulated by ZO-2-mediated inhibition of the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling pathway
the first PDZ domain of ZO-2 interacts with YAP2 to form complex; ZO-2 facilitates both nuclear translocation of YAP2 & pro-apoptotic function of YAP2; these activities of ZO-2 are PDZ-domain-dependent
Male ZO-2 chimeras show reduced fertility and pathological changes in the testis. Lanthanum tracer experiments show a compromised blood-testis barrier.
nuclear ZO-2 is present in epithelial and endothelial cells, particularly in response to environmental stress conditions
ZO-1 (show TJP1 Proteins) and ZO-2 function redundantly to some extent in junction formation/epithelial polarization but they are not functionally identical
These findings indicate that ZO-1 (show TJP1 Proteins) and ZO-2 can independently determine whether and where claudins are polymerized.
These results suggest novel roles for ZO proteins as Src (show SRC Proteins)/Csk (show CSK Proteins) scaffolds potentially involved in the regulation of Src (show SRC Proteins) transformation.
Early embryonic lethality of mice lacking Tjp2, but not Tjp3 (show TJP3 Proteins), reveal critical and nonredundant roles for individual zonula occludens proteins in mammalian development.
This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene.
tight junction protein 2 (zona occludens 2)
, Friedreich ataxia region gene X104 (tight junction protein ZO-2)
, tight junction protein ZO-2
, zona occludens 2
, zonula occludens protein 2
, Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2)
, zona occludens protein 2