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TJP2 encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. Additionally we are shipping TJP2 Kits (6) and TJP2 Proteins (4) and many more products for this protein.
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Human Polyclonal TJP2 Primary Antibody for ICC, IF - ABIN4359740
González-Andrades, Garzón, Gascón, Muñoz-Avila, Sánchez-Quevedo, Campos, Alaminos: Sequential development of intercellular junctions in bioengineered human corneas. in Journal of tissue engineering and regenerative medicine 2009
Show all 2 Pubmed References
Patients with a confirmed ABCB11 (show ABCB11 Antibodies) or tight junction protein 2 gene mutation (n = 7) had a minimally detectable THBA proportion (0.23-2.99% of total BAs). Three patients with an ATP8B1 (show ATP8B1 Antibodies) mutation had an elevated THBA proportion (7.51-37.26%).
Studies indicate the modular and supramodular organization of zonula occludens protein 2 (ZO-2) that allows it to interact with a wide variety of molecules, including cell-cell adhesion proteins, cytoskeletal components, and nuclear factors.
Data identified two Disease-causing Genes TJP2 and GJB2 (show GJB2 Antibodies) in a Chinese Family with Unconditional Autosomal Dominant Nonsyndromic Hereditary Hearing Impairment.
TJP2 deficiency may predispose to hepatocellular carcinoma in early childhood
Claudin-19 (show CLDN19 Antibodies), the most abundant claudin in myelin, exhibited no binding to ZO2.
JAM-A (show F11R Antibodies) regulates epithelial permeability via association with ZO-2, afadin (show MLLT4 Antibodies), and PDZ-GEF1 (show RAPGEF2 Antibodies) to activate Rap2c (show RAP2C Antibodies) and control contraction of the apical cytoskeleton.
Protein-truncating mutations in the tight junction protein 2 gene cause failure of protein localization and disruption of tight-junction structure, leading to severe cholestatic liver disease.
demonstrated that ZO-2 inhibition increases invasive and migrative capacities of invasive tumor cells. This was associated with an increase of MT1-MMP (show MMP14 Antibodies)
the Alu-related transcript of TJP2 gene (TJP2-Alu transcript) was differentially expressed between colorectal tumor and normal tissues; potential diagnostic markers for colorectal cancer.
ZO-2 inhibits the Wnt (show WNT2 Antibodies) signaling pathway, reduces cell proliferation, and promotes apoptosis; its absence, mutation, or overexpression is present in various human diseases, including deafness and cancer.
Expression of Podocalyxin (show PODXL Antibodies), which positively regulates the formation of microvilli and the apical membrane, is repressed in embryoid bodies lacking both ZO-1 (show TJP1 Antibodies) and ZO-2 and this correlates with an aberrant submembranous localization of Ezrin (show EZR Antibodies).
SNX27 (show SNX27 Antibodies) associates with ZO-2 and modulates the epithelial tight junction.
ZO-2 protects against podocyte dysfunction induced by adreiamycin. This action is regulated by ZO-2-mediated inhibition of the Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling pathway
the first PDZ domain (show INADL Antibodies) of ZO-2 interacts with YAP2 (show YAP1 Antibodies) to form complex; ZO-2 facilitates both nuclear translocation of YAP2 (show YAP1 Antibodies) & pro-apoptotic function of YAP2 (show YAP1 Antibodies); these activities of ZO-2 are PDZ-domain (show INADL Antibodies)-dependent
Male ZO-2 chimeras show reduced fertility and pathological changes in the testis. Lanthanum tracer experiments show a compromised blood-testis barrier.
nuclear ZO-2 is present in epithelial and endothelial cells, particularly in response to environmental stress conditions
ZO-1 (show TJP1 Antibodies) and ZO-2 function redundantly to some extent in junction formation/epithelial polarization but they are not functionally identical
These findings indicate that ZO-1 (show TJP1 Antibodies) and ZO-2 can independently determine whether and where claudins are polymerized.
These results suggest novel roles for ZO proteins as Src (show SRC Antibodies)/Csk (show CSK Antibodies) scaffolds potentially involved in the regulation of Src (show SRC Antibodies) transformation.
Early embryonic lethality of mice lacking Tjp2, but not Tjp3 (show TJP3 Antibodies), reveal critical and nonredundant roles for individual zonula occludens proteins in mammalian development.
This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene.
tight junction protein 2 (zona occludens 2)
, Friedreich ataxia region gene X104 (tight junction protein ZO-2)
, tight junction protein ZO-2
, zona occludens 2
, zonula occludens protein 2
, Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2)
, zona occludens protein 2