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TJP3 is a member of the family of membrane-associated guanylate kinase-like proteins (MAGUK) that associate with intracellular junctions (Itoh et al., 1999. Additionally we are shipping Tight Junction Protein 3 (Zona Occludens 3) Antibodies (59) and Tight Junction Protein 3 (Zona Occludens 3) Proteins (3) and many more products for this protein.
analysis of tissue distribution and developmental expression of tjp1/zo-1 (show TJP1 ELISA Kits), tjp2/zo-2 (show TJP2 ELISA Kits) and tjp3/zo-3 in the zebrafish, Danio rerio
Tjp3/Zo-3 is critical for barrier function of the enveloping cell layer and osmoregulation in early stages of zebrafish development.
Tight function zonula occludens-3 regulates cyclin D1 (show CCND1 ELISA Kits)-dependent cell proliferation
ZO-3 (-/-) mice were viable and fertile and their tight junctions did not appear to be affected.
Early embryonic lethality of mice lacking Tjp2 (show TJP2 ELISA Kits), but not Tjp3, reveals critical and nonredundant roles for individual zonula occludens proteins in mammalian development.
ZO-3 shows an epithelial-specific Tight junctions localization
The protein encoded by this gene is a member of the membrane-associated guanylate kinase-like (MAGUK) protein family which is characterized by members having multiple PDZ domains, a single SH3 domain, and a single guanylate kinase-like (GUK)-domain. In addition, members of the zonula occludens protein subfamily have an acidic domain, a basic arginine-rich region, and a proline-rich domain. The protein encoded by this gene plays a role in the linkage between the actin cytoskeleton and tight-junctions and also sequesters cyclin D1 at tight junctions during mitosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. This gene has a partial pseudogene on chromosome 1.
tight junction protein 3 (zona occludens 3)
, tight junction protein ZO-3
, tight junction protein 3
, zona occludens protein 3
, zonula occludens protein 3