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anti-Titin (TTN) Antibodies

TTN encodes a large abundant protein of striated muscle. Additionally we are shipping Titin Kits (15) and Titin Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TTN 7273 Q8WZ42
TTN 84015  
TTN 22138  
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Top anti-Titin Antibodies at antibodies-online.com

Showing 10 out of 56 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated IF, IHC (p), ELISA, WB Immunoperoxidase of monoclonal antibody to TTN on formalin-fixed paraffin-embedded human skeletal muscle. [antibody concentration 1 ug/ml] Detection limit for recombinant GST tagged TTN is approximately 0.03ng/ml as a capture antibody. 100 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated IF (p), IHC (p) Antigen: 2 µg/100 µL  Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000;  Secondary: HRP conjugated Rabbit Anti-Goat IgG at 1: 5000;  TMB staining Read the data in Microplate Reader by 450nm. Formalin-fixed and paraffin embedded rat heart labeled with Anti-Titin/CMD1G Polyclonal Antibody, Unconjugated (ABIN1387283) at 1:200 followed by conjugation to the secondary antibody and DAB staining. 100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Mouse Un-conjugated WB Western Blot analysis of TTN expression in transfected 293T cell line by TTN monoclonal antibody (M09), clone 6H5. Lane 1: TTN transfected lysate(32.8 KDa). Lane 2: Non-transfected lysate. Immunoperoxidase of monoclonal antibody to TTN on formalin-fixed paraffin-embedded human heart (antibody concentration 3 µg/mL). 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Mouse Un-conjugated IHC (p), ELISA, WB Immunoperoxidase of monoclonal antibody to TTN on formalin-fixed paraffin-embedded human heart (antibody concentration 3 µg/mL).  Detection limit for recombinant GST tagged TTN is approximately 0.03 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Alexa Fluor 350 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 488 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 555 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Biotin IHC (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit FITC IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 647 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details

TTN Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Titin Antibodies

  1. Human Monoclonal Titin Primary Antibody for IF, IHC (p) - ABIN563282 : Choi, Park, Yi, Kim: Novel Mutation of the GNE Gene Presenting Atypical Mild Clinical Feature: A Korean Case Report. in Annals of rehabilitation medicine 2015 (PubMed)

More Antibodies against Titin Interaction Partners

Fruit Fly (Drosophila melanogaster) Titin (TTN) interaction partners

  1. Sls is a novel hub gene responsible for the regulation of mitochondrial respiration in the muscle sarcomere.

  2. Projectin immunolocalization studies during myofibrillogenesis in Drosophila indirect flight muscles.

  3. Projectin is oriented within the indirect flight muscles sarcomere with its NH2-terminus embedded in the Z-bands. This protein has an elastic region, possibly the PEVK-like domain located close to the NH2-terminus.

  4. Alternative Sls isoforms could regulate the stiffness of the many fibre types in Drosophila muscles.

  5. Results reveal a role for Mlp84B in maintaining muscle structural integrity, and suggest Mlp84B and D-titin cooperate to stabilize muscle sarcomeres.

Cow (Bovine) Titin (TTN) interaction partners

  1. titin may be a factor involved in the Frank-Starling mechanism of the heart by promoting actomyosin interaction in response to stretch

  2. calcium affects passive myocardial tension in a titin isoform-dependent manner.

  3. Upon relaxation of shortened myocytes, the restoring stiffness correlates with the titin isoform expression profile with myocytes that express high levels of the stiff isoform (N2B) having the highest restoring stiffness.

Rabbit Titin (TTN) interaction partners

  1. Suggest that the increase in the static tension in activated striated muscle is directly associated with Ca(2+)-dependent change in titin properties and not associated with changes in titin-actin interactions.

  2. titin's visco-elastic properties appear to depend on the Ig do- main un/refolding kinetics and that indeed, titin (and thus myofibrils) can become virtually elastic when Ig domain un/refolding is prevented.

  3. Under non-equilibrium conditions across the physiological force range, titin extends by a complex pattern of history-dependent discrete conformational transitions.

  4. We tested the hypothesis that titin properties might be reflected well in single myofibrils. mechanics of titin are well preserved in isolated myofibrils.

  5. Titin might be responsible for passive force enhancement observed in myofibrils.

  6. The structure and self-interactive properties of an approximately 290 kDa ( approximately 100 nm long) tryptic fragment from the I-band part of titin that is extensible in situ, is presented.

  7. results suggest residual force enhancement in skeletal muscle fibers is caused by stiffening of titin upon muscle activation but not with titin binding to actin; finding indicates existence of a Ca(2 (show CA2 Antibodies)+)-regulated, titin-based stiffness in skeletal muscle

Human Titin (TTN) interaction partners

  1. Phosphorylating Titin's Cardiac N2B Element by ERK2 (show MAPK1 Antibodies) or CaMKIIdelta Lowers the Single Molecule and Cardiac Muscle Force

  2. Suggest a potential biological role for some TTN missense variants in dilated cardiomyopathy.

  3. Data suggest that titin functions as an integrated protein chain where functionalities emerge from the joint action of titan and other sarcomere/A-band components (such as TCAP (show TCAP Antibodies)); titin exhibits tertiary elasticity and molecular shape memory. [REVIEW]

  4. a large number of VUS in the TTN gene were identified from a cohort of samples from patients suffering cardiac diseases associated with sudden cardiac death.

  5. TTN mutations have been strongly associated with four cardiomyopathies: Dilated cardiomyopathy, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy and Restrictive cardiomyopathy.

  6. Cleavage of C-terminal titin by CAPN3 (show CAPN3 Antibodies) is associated with limb-girdle muscular dystrophy 2A and tibial muscular dystrophy.

  7. findings indicate that titin mutations cause dilated cardiomyopathy by disrupting critical linkages between sarcomerogenesis and adaptive remodeling

  8. Engineered all four of the naturally occurring human M10 (the extreme C-terminus of titin) missense mutants and biophysically characterized them in vitro.

  9. an increase in intracellular Ca(2 (show CA2 Antibodies)+) concentration leads to Ca(2 (show CA2 Antibodies)+) binding to the PEVK region of titin.

  10. An increase in the degree of titin phosphorylation results in increased proteolytic degradation of this protein, that contributes to the development of skeletal muscle atrophy.

Pig (Porcine) Titin (TTN) interaction partners

  1. Two polymorphisms previously identified and described in the 3'UTR (show UTS2R Antibodies) of MYPN (show MYPN Antibodies) and TTN genes in a group of Italian Large White (ILW) and Italian Duroc (ID) pigs, were analysed.

  2. Titin-actin interaction: PEVK-actin-based viscosity in a large animal.

  3. Neonatal pig hearts showed large N2BA-titin isoforms distinct from those present in the adult porcine myocardium.

  4. findings demonstrate that Tn plays an important role in the Frank-Starling mechanism of the heart via on-off switching of the thin filament state, in concert with titin-based regulation

  5. Report PKC phosphorylation of titin's PEVK element: a novel and conserved pathway for modulating myocardial stiffness.

  6. Coexpression of the 2 titin isoforms in large mammals allows longer sarcomere lengths without the development of excessive diastolic tension.

Mouse (Murine) Titin (TTN) interaction partners

  1. Phosphorylating Titin's Cardiac N2B Element by ERK2 (show MAPK1 Antibodies) or CaMKIIdelta Lowers the Single Molecule and Cardiac Muscle Force

  2. Cleavage of C-terminal titin by CAPN3 (show CAPN3 Antibodies) is associated with limb-girdle muscular dystrophy 2A and tibial muscular dystrophy.

  3. titin affects the tuning of shivering frequency

  4. An increase in the degree of titin phosphorylation results in increased proteolytic degradation of this protein, that contributes to the development of skeletal muscle atrophy.

  5. Pure volume overload induces an increase in titin stiffness that is beneficial and limits eccentric remodeling.

  6. increased titin stiffness promotes myocardial contraction by accelerating the formation of force-generating cross-bridges without decelerating relaxation

  7. alpha-Synemin (show SYNM Antibodies) localizes to the M-band of the sarcomere through interaction with the M10 region of titin

  8. Data reveal that Titin protein is a pseudokinase with non-detectable catalytic output but is a high-affinity binding locus for MuRF1 (show TRIM63 Antibodies).

  9. [review] A mouse model lacking nine titin immunoglobulin domains (IG KO) shows the effects of a small increase in titin stiffness; the mutant mice show changes in muscle contractivity.

  10. Resting and dynamic LV torsional mechanics is impaired in patients with beta-thalassaemia major. Cell and animal models suggest a potential role of titin degradation in iron overload-induced alteration of LV torsional mechanics.

Titin (TTN) Antigen Profile

Protein Summary

This gene encodes a large abundant protein of striated muscle. The product of this gene is divided into two regions, a N-terminal I-band and a C-terminal A-band. The I-band, which is the elastic part of the molecule, contains two regions of tandem immunoglobulin domains on either side of a PEVK region that is rich in proline, glutamate, valine and lysine. The A-band, which is thought to act as a protein-ruler, contains a mixture of immunoglobulin and fibronectin repeats, and possesses kinase activity. An N-terminal Z-disc region and a C-terminal M-line region bind to the Z-line and M-line of the sarcomere, respectively, so that a single titin molecule spans half the length of a sarcomere. Titin also contains binding sites for muscle associated proteins so it serves as an adhesion template for the assembly of contractile machinery in muscle cells. It has also been identified as a structural protein for chromosomes. Alternative splicing of this gene results in multiple transcript variants. Considerable variability exists in the I-band, the M-line and the Z-disc regions of titin. Variability in the I-band region contributes to the differences in elasticity of different titin isoforms and, therefore, to the differences in elasticity of different muscle types. Mutations in this gene are associated with familial hypertrophic cardiomyopathy 9, and autoantibodies to titin are produced in patients with the autoimmune disease scleroderma.

Gene names and symbols associated with anti-Titin (TTN) Antibodies

  • bent (bt) antibody
  • sallimus (sls) antibody
  • connectin (LOC530831) antibody
  • titin (titin) antibody
  • TITIN protein (TITIN) antibody
  • titin (TTN) antibody
  • titin (TTNLOC100620261) antibody
  • titin (Ttn) antibody
  • 0020/01 antibody
  • 39c-18 antibody
  • 1100001C23Rik antibody
  • 2310036G12Rik antibody
  • 2310057K23Rik antibody
  • 2310074I15Rik antibody
  • AF006999 antibody
  • anon-CREST antibody
  • AV006427 antibody
  • Bt antibody
  • CG1479 antibody
  • CG1915 antibody
  • CG10285 antibody
  • CG18242 antibody
  • CG18245 antibody
  • CG18857 antibody
  • CG32019 antibody
  • CMD1G antibody
  • CMH9 antibody
  • CMPD4 antibody
  • CT3598 antibody
  • CT8086 antibody
  • CT41299 antibody
  • d-titin antibody
  • D330041I19Rik antibody
  • D830007G01Rik antibody
  • Dmel\\CG1915 antibody
  • Dmel\\CG32019 antibody
  • EOMFC antibody
  • HMERF antibody
  • ket antibody
  • kettin antibody
  • KZ antibody
  • l(2)2 antibody
  • l(2)23 antibody
  • l(3)62Ca antibody
  • l(3)Ca antibody
  • l(3)dre8 antibody
  • l(3)j1D7 antibody
  • l(3)rL182 antibody
  • l(3)S002001 antibody
  • l(4)2 antibody
  • l(4)21 antibody
  • l(4)23 antibody
  • l(4)37 antibody
  • l(4)38 antibody
  • l(4)102CDa antibody
  • l(4)PT-2 antibody
  • L56 antibody
  • LGMD2J antibody
  • LOC530831 antibody
  • MCP antibody
  • mdm antibody
  • MYLK5 antibody
  • Prj antibody
  • sal antibody
  • sam antibody
  • shru antibody
  • Sls antibody
  • TITIN antibody
  • TMD antibody
  • UNC-22 antibody

Protein level used designations for anti-Titin (TTN) Antibodies

C-protein , CG32019-PC , CG32019-PF , CG32019-PH , CG32019-PI , bt-PC , bt-PF , bt-PH , bt-PI , lethal(4) Powell, Tennessee-2 , myosin LCK , projectin , projectin myosin light chain kinase , twitchin , CG1915-PA , CG1915-PD , CG1915-PP , CG1915-PQ , CG1915-PR , CG1915-PS , CG1915-PT , CG1915-PU , CG1915-PV , CG1915-PW , CG1915-PX , CG1915-PY , CG1915-PZ , D-titin , D-titin-KZ , dtitin , kettin , lethal (3) S002001 , lethal(3)62Ca , mitotic chromosomal protein , salimus , sls-PA , sls-PD , sls-PP , sls-PQ , sls-PR , sls-PS , sls-PT , sls-PU , sls-PV , sls-PW , sls-PX , sls-PY , sls-PZ , titin , connectin , TITIN protein , rhabdomyosarcoma antigen MU-RMS-40.14 , titin protein homolog

GENE ID SPECIES
43814 Drosophila melanogaster
44013 Drosophila melanogaster
530831 Bos taurus
1791505 Rhodopirellula baltica SH 1
100101565 Oryctolagus cuniculus
424126 Gallus gallus
7273 Homo sapiens
100620261 Sus scrofa
100008570 Oryctolagus cuniculus
84015 Rattus norvegicus
22138 Mus musculus
540561 Bos taurus
100722767 Cavia porcellus
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