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Toll Interacting Protein Proteins (TOLLIP)

TOLLIP encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. Additionally we are shipping TOLLIP Antibodies (127) and TOLLIP Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TOLLIP 54472 Q9H0E2
TOLLIP 54473 Q9QZ06
Rat TOLLIP TOLLIP 361677 A2RUW1
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Top TOLLIP Proteins at antibodies-online.com

Showing 10 out of 16 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 7 to 8 Days
$407.00
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$721.60
Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$739.20
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,709.67
Details
Yeast Esox lucius His tag   1 mg Log in to see 56 to 66 Days
$2,718.83
Details
Yeast REACT_Atlantic Salmon His tag   1 mg Log in to see 56 to 66 Days
$2,718.83
Details
Yeast Zebrafish His tag   1 mg Log in to see 56 to 66 Days
$2,722.50
Details

TOLLIP Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)
,

Top referenced TOLLIP Proteins

  1. Human TOLLIP Protein expressed in Escherichia coli (E. coli) - ABIN667913 : Burns, Clatworthy, Martin, Martinon, Plumpton, Maschera, Lewis, Ray, Tschopp, Volpe: Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor. in Nature cell biology 2000 (PubMed)
    Show all 2 references for ABIN667913

More Proteins for Toll Interacting Protein (TOLLIP) Interaction Partners

Human Toll Interacting Protein (TOLLIP) interaction partners

  1. Tom1 (show TOM1 Proteins) modulates binding of Tollip to phosphatidylinositol 3-phosphate via a coupled folding and binding mechanism.

  2. These data suggest that M. leprae upregulates IL-1Ra (show IL1RN Proteins) by a TOLLIP-dependent mechanism; inhibition of TOLLIP may decrease an individual's susceptibility to leprosy and offer a novel therapeutic target for IL-1 (show IL1A Proteins)-dependent diseases.

  3. Observed expression patterns of several TLR inhibitory proteins with a noticeable suppression in expression of two of these; PPARgamma (show PPARG Proteins) and TOLLIP in both ulcerative colitis and Crohn's disease and in both active and inactive disease states.

  4. Tollip acts as a novel modulator of I/R injury by promoting neuronal apoptosis and ischaemic inflammation, which are largely mediated by suppression of Akt (show AKT1 Proteins) signalling.

  5. The two polymorphisms, rs5743899 and rs3750920, in the TOLLIP gene are independently associated with an increased risk of developing cutaneous leishmaniasis (CL).

  6. TOLLIP encodes toll-interacting protein (TOLLIP), which is an inhibitory adaptor protein acting downstream from the toll (show TLR4 Proteins)-like receptors (TLRs). Read More: http://www.atsjournals.org/doi/full/10.1164/rccm.201505-1010OC#.VwqiYdLrvyA

  7. we identify a novel function of Tollip in regulating the canonical Wnt (show WNT2 Proteins) pathway which is evolutionarily conserved between fish and humans. Tollip-mediated inhibition of Wnt (show WNT2 Proteins) signaling may contribute to embryonic development and to carcinogenesis.

  8. TOLLIP contributes to mortality following myocardial infarction through promoting inflammation and apoptosis

  9. Study shows that host factor Tollip inhibits HIV LTR-driven gene expression by suppressing NF-kappaB (show NFKB1 Proteins) activation revealing its novel role in modulating HIV-1 infection.

  10. Which is achieved by elevated level of toll-interacting protein (TOLLIP) in presence of porin (show VDAC1 Proteins).

Mouse (Murine) Toll Interacting Protein (TOLLIP) interaction partners

  1. Tollip acts as a novel modulator of I/R injury by promoting neuronal apoptosis and ischaemic inflammation, which are largely mediated by suppression of Akt (show AKT1 Proteins) signalling.

  2. TOLLIP contributes to mortality following myocardial infarction through promoting inflammation and apoptosis

  3. Data show that histone lysine methyltransferase Ezh1 (show EZH1 Proteins) promotes toll (show TLR4 Proteins)-like receptor (TLR)-triggered inflammatory cytokine production by suppressing the Toll-interacting protein (Tollip), contributing to full activation of the innate immunity.

  4. Overall, our data show an essential role for Tollip on colitis susceptibility in mice.

  5. negative regulator of pathological cardiac hypertrophy by blocking the AKT (show AKT1 Proteins) signalling pathway

  6. Tollip cooperates with Smad7 (show SMAD7 Proteins) to modulate intracellular trafficking and degradation of ubiquitinated TbetaRI (show TGFBR1 Proteins), whereby negatively regulates TGF-beta (show TGFB1 Proteins) signaling pathway.

  7. DNA and protein coimmunization induces regulatory dendritic cells through caveolin-1 (show CAV1 Proteins)- and Tollip-mediated negative signaling.

  8. Low-dose lipopolysaccharide utilizes Tollip and interleukin (IL)-1 (show IL1A Proteins) receptor-associated kinase (IRAK)-1 (show IRAK1 Proteins) to induce mitochondrial reactive oxygen species to subsequently induce activating transcription factor (ATF)2 (show ATF2 Proteins) in chronic low-grade inflammatory disease.

  9. Tollip is a critical mediator responsible for the anti-inflammatory action of epigallocatechin-3-gallate in activated macrophages.

  10. a Tom1-Tollip complex functions as a factor that links polyubiquitinated proteins to clathrin

Atlantic Salmon (Salmo salar) Toll Interacting Protein (TOLLIP) interaction partners

  1. identified two closely related Tollip-encoding genes in Atlantic salmon (Salmo salar)

TOLLIP Protein Profile

Protein Summary

This gene encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor trafficking and in the turnover of IL1R-associated kinase.

Gene names and symbols associated with TOLLIP

  • toll interacting protein (tollip)
  • toll interacting protein (TOLLIP)
  • toll interacting protein (Tollip)
  • toll-interacting protein (Tollip)
  • toll interacting protein (tollip-b)
  • toll interacting protein (tollip-a)
  • 4930403G24Rik protein
  • 4931428G15Rik protein
  • fk22a02 protein
  • GB17961 protein
  • IL-1RAcPIP protein
  • im:7145391 protein
  • tollip protein
  • wu:fk22a02 protein
  • zgc:76985 protein

Protein level used designations for TOLLIP

toll-interacting protein , toll interacting protein , adapter protein , toll-interacting protein B , toll-interacting protein A , Toll-interleukin 1 receptor interacting protein

GENE ID SPECIES
448770 Xenopus (Silurana) tropicalis
483657 Canis lupus familiaris
552034 Apis mellifera
702587 Macaca mulatta
450943 Pan troglodytes
100616078 Amphimedon queenslandica
54472 Homo sapiens
54473 Mus musculus
361677 Rattus norvegicus
336876 Danio rerio
443846 Xenopus laevis
423099 Gallus gallus
539480 Bos taurus
734800 Xenopus laevis
100169858 Salmo salar
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