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TOLLIP encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. Additionally we are shipping TOLLIP Antibodies (166) and TOLLIP Kits (9) and many more products for this protein.
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Human TOLLIP Protein expressed in Escherichia coli (E. coli) - ABIN667913
Burns, Clatworthy, Martin, Martinon, Plumpton, Maschera, Lewis, Ray, Tschopp, Volpe: Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor. in Nature cell biology 2000
Show all 2 references for ABIN667913
Toll-interacting protein rs5743867 polymorphism tends to decrease the risk of sepsis in infants undergoing complex open heart surgery.
Variants in the TOLLIP gene are associated with higher circulating PAI-1 (show SERPINE1 Proteins) plasma levels and association with clinical Primary Graft Dysfunction Risk.
Tom1 (show TOM1 Proteins) modulates binding of Tollip to phosphatidylinositol 3-phosphate via a coupled folding and binding mechanism.
These data suggest that M. leprae upregulates IL-1Ra (show IL1RN Proteins) by a TOLLIP-dependent mechanism; inhibition of TOLLIP may decrease an individual's susceptibility to leprosy and offer a novel therapeutic target for IL-1 (show IL1A Proteins)-dependent diseases.
Observed expression patterns of several TLR inhibitory proteins with a noticeable suppression in expression of two of these; PPARgamma (show PPARG Proteins) and TOLLIP in both ulcerative colitis and Crohn's disease and in both active and inactive disease states.
Tollip acts as a novel modulator of I/R injury by promoting neuronal apoptosis and ischaemic inflammation, which are largely mediated by suppression of Akt (show AKT1 Proteins) signalling.
The two polymorphisms, rs5743899 and rs3750920, in the TOLLIP gene are independently associated with an increased risk of developing cutaneous leishmaniasis (CL).
TOLLIP encodes toll-interacting protein (TOLLIP), which is an inhibitory adaptor protein acting downstream from the toll (show TLR4 Proteins)-like receptors (TLRs). Read More: http://www.atsjournals.org/doi/full/10.1164/rccm.201505-1010OC#.VwqiYdLrvyA
we identify a novel function of Tollip in regulating the canonical Wnt (show WNT2 Proteins) pathway which is evolutionarily conserved between fish and humans. Tollip-mediated inhibition of Wnt (show WNT2 Proteins) signaling may contribute to embryonic development and to carcinogenesis.
TOLLIP contributes to mortality following myocardial infarction through promoting inflammation and apoptosis
Data show that histone lysine methyltransferase Ezh1 (show EZH1 Proteins) promotes toll (show TLR4 Proteins)-like receptor (TLR)-triggered inflammatory cytokine production by suppressing the Toll-interacting protein (Tollip), contributing to full activation of the innate immunity.
Overall, our data show an essential role for Tollip on colitis susceptibility in mice.
negative regulator of pathological cardiac hypertrophy by blocking the AKT (show AKT1 Proteins) signalling pathway
Tollip cooperates with Smad7 (show SMAD7 Proteins) to modulate intracellular trafficking and degradation of ubiquitinated TbetaRI (show TGFBR1 Proteins), whereby negatively regulates TGF-beta (show TGFB1 Proteins) signaling pathway.
DNA and protein coimmunization induces regulatory dendritic cells through caveolin-1 (show CAV1 Proteins)- and Tollip-mediated negative signaling.
Low-dose lipopolysaccharide utilizes Tollip and interleukin (IL)-1 (show IL1A Proteins) receptor-associated kinase (IRAK)-1 (show IRAK1 Proteins) to induce mitochondrial reactive oxygen species to subsequently induce activating transcription factor (ATF)2 (show ATF2 Proteins) in chronic low-grade inflammatory disease.
Tollip is a critical mediator responsible for the anti-inflammatory action of epigallocatechin-3-gallate in activated macrophages.
a Tom1-Tollip complex functions as a factor that links polyubiquitinated proteins to clathrin
identified two closely related Tollip-encoding genes in Atlantic salmon (Salmo salar)
This gene encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor trafficking and in the turnover of IL1R-associated kinase.
, toll interacting protein
, adapter protein
, toll-interacting protein B
, toll-interacting protein A
, Toll-interleukin 1 receptor interacting protein