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TOLLIP encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. Additionally we are shipping TOLLIP Antibodies (168) and TOLLIP Proteins (17) and many more products for this protein.
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Toll-interacting protein rs5743867 polymorphism tends to decrease the risk of sepsis in infants undergoing complex open heart surgery.
Variants in the TOLLIP gene are associated with higher circulating PAI-1 (show SERPINE1 ELISA Kits) plasma levels and association with clinical Primary Graft Dysfunction Risk.
Tom1 (show TOM1 ELISA Kits) modulates binding of Tollip to phosphatidylinositol 3-phosphate via a coupled folding and binding mechanism.
These data suggest that M. leprae upregulates IL-1Ra (show IL1RN ELISA Kits) by a TOLLIP-dependent mechanism; inhibition of TOLLIP may decrease an individual's susceptibility to leprosy and offer a novel therapeutic target for IL-1 (show IL1A ELISA Kits)-dependent diseases.
Observed expression patterns of several TLR inhibitory proteins with a noticeable suppression in expression of two of these; PPARgamma (show PPARG ELISA Kits) and TOLLIP in both ulcerative colitis and Crohn's disease and in both active and inactive disease states.
Tollip acts as a novel modulator of I/R injury by promoting neuronal apoptosis and ischaemic inflammation, which are largely mediated by suppression of Akt (show AKT1 ELISA Kits) signalling.
The two polymorphisms, rs5743899 and rs3750920, in the TOLLIP gene are independently associated with an increased risk of developing cutaneous leishmaniasis (CL).
TOLLIP encodes toll-interacting protein (TOLLIP), which is an inhibitory adaptor protein acting downstream from the toll (show TLR4 ELISA Kits)-like receptors (TLRs). Read More: http://www.atsjournals.org/doi/full/10.1164/rccm.201505-1010OC#.VwqiYdLrvyA
we identify a novel function of Tollip in regulating the canonical Wnt (show WNT2 ELISA Kits) pathway which is evolutionarily conserved between fish and humans. Tollip-mediated inhibition of Wnt (show WNT2 ELISA Kits) signaling may contribute to embryonic development and to carcinogenesis.
TOLLIP contributes to mortality following myocardial infarction through promoting inflammation and apoptosis
Data show that histone lysine methyltransferase Ezh1 (show EZH1 ELISA Kits) promotes toll (show TLR4 ELISA Kits)-like receptor (TLR)-triggered inflammatory cytokine production by suppressing the Toll-interacting protein (Tollip), contributing to full activation of the innate immunity.
Overall, our data show an essential role for Tollip on colitis susceptibility in mice.
negative regulator of pathological cardiac hypertrophy by blocking the AKT (show AKT1 ELISA Kits) signalling pathway
Tollip cooperates with Smad7 (show SMAD7 ELISA Kits) to modulate intracellular trafficking and degradation of ubiquitinated TbetaRI (show TGFBR1 ELISA Kits), whereby negatively regulates TGF-beta (show TGFB1 ELISA Kits) signaling pathway.
DNA and protein coimmunization induces regulatory dendritic cells through caveolin-1 (show CAV1 ELISA Kits)- and Tollip-mediated negative signaling.
Low-dose lipopolysaccharide utilizes Tollip and interleukin (IL)-1 (show IL1A ELISA Kits) receptor-associated kinase (IRAK)-1 (show IRAK1 ELISA Kits) to induce mitochondrial reactive oxygen species to subsequently induce activating transcription factor (ATF)2 (show ATF2 ELISA Kits) in chronic low-grade inflammatory disease.
Tollip is a critical mediator responsible for the anti-inflammatory action of epigallocatechin-3-gallate in activated macrophages.
a Tom1-Tollip complex functions as a factor that links polyubiquitinated proteins to clathrin
identified two closely related Tollip-encoding genes in Atlantic salmon (Salmo salar)
This gene encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor trafficking and in the turnover of IL1R-associated kinase.
, toll interacting protein
, adapter protein
, toll-interacting protein B
, toll-interacting protein A
, Toll-interleukin 1 receptor interacting protein