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Participates in the innate immune response to microbial agents. Additionally we are shipping Toll-Like Receptor 12 Proteins (4) and many more products for this protein.
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Biochemical experiments revealed that TLR11 (show Tlr11 Antibodies) and TLR12 directly bind to Toxoplasma gondii profilin (show PFN1 Antibodies) and are capable of forming a heterodimer complex.
While parasite RNA and DNA activate innate immune responses via TLR7 (show TLR7 Antibodies) and TLR9 (show TLR9 Antibodies), TLR11 (show Tlr11 Antibodies) and TLR12 heterodimers are required for sensing and responding to Toxoplasma profilin (show PFN1 Antibodies) infection.
Recognition of profilin (show PFN1 Antibodies) by Toll-like receptor 12 is critical for host resistance to Toxoplasma gondii.
Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Plays a role in preventing infection of internal organs of the urogenital system.