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anti-Topoisomerase (DNA) II Binding Protein 1 (TOPBP1) Antibodies

TOPBP1 encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. Additionally we are shipping Topoisomerase (DNA) II Binding Protein 1 Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TOPBP1 315969  
TOPBP1 11073 Q92547
TOPBP1 235559 Q6ZQF0
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Top anti-Topoisomerase (DNA) II Binding Protein 1 Antibodies at antibodies-online.com

Showing 10 out of 69 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IP, WB 50 μg Log in to see 6 to 8 Days
$456.50
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of anti-p16-INK4A Pab  in A2058 cell line lysate (35ug/lane). p16-INK4A(arrow) was detected using the purified Pab. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated IF, WB Western blot analysis of TopBP1 on a Jurkat cell lysate (Human T-cell leukemia, ATCC TIB-152). Lane 1: 1:250, lane 2: 1:500, lane 3: 1:1000 dilution of the mouse anti-human TopBP1 antibody. Immunofluorescence staining of HeLa cells (Human cervical epitheloid carcinoma, ATCC CCL-2.2). 50 μg Log in to see 5 to 6 Days
$205.42
Details
Human Rabbit Un-conjugated DB Dot blot analysis of Phospho-YAP-S127 antibody Phospho-specific Pab  on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IP, PLA, WB Western blot detection of Human TopBP1, using ABIN151595. Sample: Whole cell lysate (50 ug for WB) from HeLa cells. 100 μL Log in to see 5 to 7 Days
$477.75
Details
Human Rabbit Un-conjugated WB WB Image TOPBP1 antibody detects TOPBP1 protein by western blot analysis. Various whole cell extracts (30 μg) were separated by 5% SDS-PAGE, and the membrane was blotted with TOPBP1 antibody , diluted at a dilution of 1:500. 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Mouse Un-conjugated ICC, WB   100 μg Log in to see 8 to 10 Days
$793.83
Details
Human Rabbit Un-conjugated WB   100 μL Log in to see 8 to 10 Days
$383.17
Details
Human Mouse Un-conjugated ELISA, WB TOPBP1 monoclonal antibody (M04), clone 6D12. Western Blot analysis of TOPBP1 expression in Jurkat. Detection limit for recombinant GST tagged TOPBP1 is 0.03 ng/ml as a capture antibody. 100 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated DB 400 μL Log in to see 6 Days
$457.14
Details

TOPBP1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Rat (Rattus)


Human , , , ,
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Mouse (Murine)


Top referenced anti-Topoisomerase (DNA) II Binding Protein 1 Antibodies

  1. Human Monoclonal TOPBP1 Primary Antibody for IF, WB - ABIN968690 : Yamane, Katayama, Tsuruo: The BRCT regions of tumor suppressor BRCA1 and of XRCC1 show DNA end binding activity with a multimerizing feature. in Biochemical and biophysical research communications 2001 (PubMed)
    Show all 3 references for ABIN968690

  2. Human Polyclonal TOPBP1 Primary Antibody for IP, WB - ABIN318944 : Yamane, Wu, Chen: A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival. in Molecular and cellular biology 2001 (PubMed)

  3. Human Polyclonal TOPBP1 Primary Antibody for IHC (p), WB - ABIN1539711 : Al-Khalaf, Hendrayani, Aboussekhra: The atr protein kinase controls UV-dependent upregulation of p16INK4A through inhibition of Skp2-related polyubiquitination/degradation. in Molecular cancer research : MCR 2011 (PubMed)

More Antibodies against Topoisomerase (DNA) II Binding Protein 1 Interaction Partners

Human Topoisomerase (DNA) II Binding Protein 1 (TOPBP1) interaction partners

  1. The innate immune regulator STAT-5 is shown to regulate transcription of the ATR binding factor TopBP1, and this is critical for the induction of the ATR pathway in human papillomavirus-infected keratinocytes.

  2. TOPBP1 physically binds PLK1 (show PLK1 Antibodies) and promotes PLK1 (show PLK1 Antibodies) kinase-mediated phosphorylation of RAD51 (show RAD51 Antibodies) at serine 14, a modification required for RAD51 (show RAD51 Antibodies) recruitment to chromatin.

  3. Functional analyses indicat that the expression TopBP1 and Claspin (show CLSPN Antibodies) positively affects the survival of brain cancer cells after exposure to radiation.

  4. TopBP1 interacts with BLM to maintain genome stability but is dispensable for preventing BLM degradation.Crucial residues mediating TopBP1-MDC1 (show MDC1 Antibodies) interactions identified.

  5. TopBP1 maintains genome integrity in mitosis by controlling chromatin recruitment of SLX4 (show BTBD12 Antibodies) and by facilitating unscheduled DNA synthesis.

  6. Findings demonstrate that TopBP1 and ATR are able to inhibit the synthesis of rRNA and to activate nucleolar stress pathway.

  7. TOPBP1 has a role in recruiting TOP2A (show TOP2A Antibodies) to ultra-fine anaphase bridges to aid in their resolution

  8. The results suggest that interactions between TopBP1 and E2 and between Brd4 (show BRD4 Antibodies) and E2 are required to correctly initiate human papillomavirus 16 DNA replication but are not required for continuing DNA replication.

  9. Phosphorylation of BRIT1 protein coordinates TopBP1 protein recruitment and amplifies ATR signaling in cell DNA damage.

  10. High TopBP1 mRNA and protein expression is associated with endometrial cancer.

Mouse (Murine) Topoisomerase (DNA) II Binding Protein 1 (TOPBP1) interaction partners

  1. Consistent with prior reports, TopBP1 co-localized in discrete nuclear foci and was in complex with papillomavirus E2 protein (show UBE2B Antibodies).

  2. The deacetylated form of TopBP1 in SIRT1 (show SIRT1 Antibodies) mutant cells repressed replication origin firing, while the acetylated form of TopBP1 lost this function.

  3. Studies identify the SIRT1 (show SIRT1 Antibodies)-TopBP1 axis as a key signaling mode in the regulation of the metabolic checkpoint and the DNA damage checkpoint.

  4. TopBP1 is a crucial factor in V(D)J rearrangement during the development of B, T and iNKT cells.

  5. Our data suggest that, unlike the yeast models, the TopBP1-AAD is the major activator of ATR, sustaining cell proliferation and embryonic development

  6. TopBP1 is crucial for maintaining genome integrity in the early progenitors that drive neurogenesis.

  7. Tethering DNA damage checkpoint mediator proteins topoisomerase IIbeta-binding protein 1 (TopBP1) and Claspin (show CLSPN Antibodies) to DNA activates ataxia-telangiectasia mutated and RAD3-related (ATR (show ATR Antibodies)) phosphorylation of checkpoint kinase 1 (Chk1 (show CHEK1 Antibodies)).

  8. TopBP1 deficiency in untransformed mouse and human primary cells induces cellular senescence rather than apoptosis. These results indicate that TopBP1 is essential for cell proliferation and maintenance of chromosomal integrity.

  9. ATR (show ATR Antibodies) and TopBP1 monitor meiotic recombination and are required for activation of the meiotic recombination checkpoint

  10. TopBP1 is a c-Abl-interacting protein and a repressor for c-Abl expression

Xenopus laevis Topoisomerase (DNA) II Binding Protein 1 (TOPBP1) interaction partners

  1. TopBP1's C-terminal motif containing a putative nuclear localization signal was required for Importin beta (show KPNB1 Antibodies) interaction and that CT100 (show DPPA2 Antibodies) of Importin beta (show KPNB1 Antibodies) was required for TopBP1 interaction.

  2. these findings indicate that WDR18 (show WDR18 Antibodies) is a bona fide checkpoint protein and that WDR18 (show WDR18 Antibodies) works together with TopBP1 to promote DNA damage checkpoint signaling.

  3. MRN (MRE11 (show MRE11A Antibodies)-RAD50 (show RAD50 Antibodies)-NBS1 (show NLRP2 Antibodies)) complex has role in ATR (show ATR Antibodies) activation via TOPBP1 recruitment.

  4. Cut5 plays an integral role in the recruitment and assembly of the Chk1 (show CHEK1 Antibodies) signaling cascade components following DNA damage

  5. Data show that Rad17 (show RAD17 Antibodies) mediates the interaction of the Rad9 (show RAD9A Antibodies)-Hus1 (show HUS1 Antibodies)-Rad1 (show ERCC4 Antibodies) (9-1-1) complex with the ATR (show ATR Antibodies)-activating protein TopBP1 in Xenopus egg extracts.

  6. Data show that recombinant TopBP1 induces a large increase in the kinase activity of both Xenopus and human ATR (show ATR Antibodies)-ATRIP (show ATRIP Antibodies).

  7. GEMC1 (show GMNC Antibodies) promotes initiation of chromosomal DNA replication in multicellular organisms by mediating TopBP1- and Cdk2 (show CDK2 Antibodies)-dependent recruitment of Cdc45 (show CDC45 Antibodies) onto replication origins.

  8. Cut5 plays a crucial role in the initial amplification step of the ATR (show ATR Antibodies)-Chk1 (show CHEK1 Antibodies) signaling pathway at the stalled replication fork.

Topoisomerase (DNA) II Binding Protein 1 (TOPBP1) Antigen Profile

Protein Summary

This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands.

Gene names and symbols associated with TOPBP1

  • topoisomerase (DNA) II binding protein 1 (Topbp1) antibody
  • topoisomerase (DNA) II binding protein 1 (topbp1) antibody
  • topoisomerase (DNA) II binding protein 1 (TOPBP1) antibody
  • dna topoisomerase ii binding protein 1 (IC) (topbp1) antibody
  • meiosis defective 1 (MEI1) antibody
  • 1110031N14Rik antibody
  • 2810429C13Rik antibody
  • AI256758 antibody
  • cut5 antibody
  • D430026L04Rik antibody
  • F2P24.3 antibody
  • F2P24_3 antibody
  • meiosis defective 1 antibody
  • mKIAA0259 antibody
  • mus101 antibody
  • RGD1562949 antibody
  • top2bp1 antibody
  • TOPBP1 antibody
  • TopBP1-A antibody
  • TopBP1-B antibody
  • Xmus101 antibody
  • XtopBP antibody

Protein level used designations for TOPBP1

DNA topoisomerase 2-binding protein 1 , topoisomerase (DNA) II beta binding protein , topoisomerase (DNA) II binding protein 1 , dna topoisomerase ii binding protein 1 (IC) , DNA topoisomerase 2-binding protein 1-like , DNA topoisomerase II-beta-binding protein 1 , DNA topoisomerase II-binding protein 1 , Cut5-related protein , DNA topoisomerase 2-binding protein 1-A , DNA topoisomerase 2-binding protein 1-B , DNA topoisomerase II-binding protein 1-A , DNA topoisomerase II-binding protein 1-B

GENE ID SPECIES
315969 Rattus norvegicus
407679 Danio rerio
420694 Gallus gallus
460709 Pan troglodytes
477070 Canis lupus familiaris
540574 Bos taurus
719054 Macaca mulatta
9837136 Ostreococcus tauri
100053011 Equus caballus
100349197 Oryctolagus cuniculus
100380063 Xenopus (Silurana) tropicalis
100403635 Callithrix jacchus
100441644 Pongo abelii
100468359 Ailuropoda melanoleuca
100542278 Meleagris gallopavo
100594594 Nomascus leucogenys
100626645 Sus scrofa
844068 Arabidopsis thaliana
11073 Homo sapiens
235559 Mus musculus
398573 Xenopus laevis
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