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TOPBP1 encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. Additionally we are shipping Topoisomerase (DNA) II Binding Protein 1 Proteins (3) and many more products for this protein.
Showing 10 out of 68 products:
Human Monoclonal TOPBP1 Primary Antibody for IF, WB - ABIN968690
Yamane, Katayama, Tsuruo: The BRCT regions of tumor suppressor BRCA1 and of XRCC1 show DNA end binding activity with a multimerizing feature. in Biochemical and biophysical research communications 2001
Show all 3 references for ABIN968690
Human Polyclonal TOPBP1 Primary Antibody for IP, WB - ABIN318944
Yamane, Wu, Chen: A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival. in Molecular and cellular biology 2001
Human Polyclonal TOPBP1 Primary Antibody for IHC (p), WB - ABIN1539711
Al-Khalaf, Hendrayani, Aboussekhra: The atr protein kinase controls UV-dependent upregulation of p16INK4A through inhibition of Skp2-related polyubiquitination/degradation. in Molecular cancer research : MCR 2011
The innate immune regulator STAT-5 is shown to regulate transcription of the ATR binding factor TopBP1, and this is critical for the induction of the ATR pathway in human papillomavirus-infected keratinocytes.
TOPBP1 physically binds PLK1 (show PLK1 Antibodies) and promotes PLK1 (show PLK1 Antibodies) kinase-mediated phosphorylation of RAD51 (show RAD51 Antibodies) at serine 14, a modification required for RAD51 (show RAD51 Antibodies) recruitment to chromatin.
Functional analyses indicat that the expression TopBP1 and Claspin (show CLSPN Antibodies) positively affects the survival of brain cancer cells after exposure to radiation.
TopBP1 interacts with BLM to maintain genome stability but is dispensable for preventing BLM degradation.Crucial residues mediating TopBP1-MDC1 (show MDC1 Antibodies) interactions identified.
TopBP1 maintains genome integrity in mitosis by controlling chromatin recruitment of SLX4 (show BTBD12 Antibodies) and by facilitating unscheduled DNA synthesis.
Findings demonstrate that TopBP1 and ATR are able to inhibit the synthesis of rRNA and to activate nucleolar stress pathway.
TOPBP1 has a role in recruiting TOP2A (show TOP2A Antibodies) to ultra-fine anaphase bridges to aid in their resolution
The results suggest that interactions between TopBP1 and E2 and between Brd4 (show BRD4 Antibodies) and E2 are required to correctly initiate human papillomavirus 16 DNA replication but are not required for continuing DNA replication.
Phosphorylation of BRIT1 protein coordinates TopBP1 protein recruitment and amplifies ATR signaling in cell DNA damage.
High TopBP1 mRNA and protein expression is associated with endometrial cancer.
Consistent with prior reports, TopBP1 co-localized in discrete nuclear foci and was in complex with papillomavirus E2 protein (show UBE2B Antibodies).
The deacetylated form of TopBP1 in SIRT1 (show SIRT1 Antibodies) mutant cells repressed replication origin firing, while the acetylated form of TopBP1 lost this function.
Studies identify the SIRT1 (show SIRT1 Antibodies)-TopBP1 axis as a key signaling mode in the regulation of the metabolic checkpoint and the DNA damage checkpoint.
TopBP1 is a crucial factor in V(D)J rearrangement during the development of B, T and iNKT cells.
Our data suggest that, unlike the yeast models, the TopBP1-AAD is the major activator of ATR, sustaining cell proliferation and embryonic development
TopBP1 is crucial for maintaining genome integrity in the early progenitors that drive neurogenesis.
Tethering DNA damage checkpoint mediator proteins topoisomerase IIbeta-binding protein 1 (TopBP1) and Claspin (show CLSPN Antibodies) to DNA activates ataxia-telangiectasia mutated and RAD3-related (ATR (show ATR Antibodies)) phosphorylation of checkpoint kinase 1 (Chk1 (show CHEK1 Antibodies)).
TopBP1 deficiency in untransformed mouse and human primary cells induces cellular senescence rather than apoptosis. These results indicate that TopBP1 is essential for cell proliferation and maintenance of chromosomal integrity.
ATR (show ATR Antibodies) and TopBP1 monitor meiotic recombination and are required for activation of the meiotic recombination checkpoint
TopBP1 is a c-Abl-interacting protein and a repressor for c-Abl expression
TopBP1's C-terminal motif containing a putative nuclear localization signal was required for Importin beta (show KPNB1 Antibodies) interaction and that CT100 (show DPPA2 Antibodies) of Importin beta (show KPNB1 Antibodies) was required for TopBP1 interaction.
these findings indicate that WDR18 (show WDR18 Antibodies) is a bona fide checkpoint protein and that WDR18 (show WDR18 Antibodies) works together with TopBP1 to promote DNA damage checkpoint signaling.
MRN (MRE11 (show MRE11A Antibodies)-RAD50 (show RAD50 Antibodies)-NBS1 (show NLRP2 Antibodies)) complex has role in ATR (show ATR Antibodies) activation via TOPBP1 recruitment.
Cut5 plays an integral role in the recruitment and assembly of the Chk1 (show CHEK1 Antibodies) signaling cascade components following DNA damage
Data show that Rad17 (show RAD17 Antibodies) mediates the interaction of the Rad9 (show RAD9A Antibodies)-Hus1 (show HUS1 Antibodies)-Rad1 (show ERCC4 Antibodies) (9-1-1) complex with the ATR (show ATR Antibodies)-activating protein TopBP1 in Xenopus egg extracts.
Data show that recombinant TopBP1 induces a large increase in the kinase activity of both Xenopus and human ATR (show ATR Antibodies)-ATRIP (show ATRIP Antibodies).
GEMC1 (show GMNC Antibodies) promotes initiation of chromosomal DNA replication in multicellular organisms by mediating TopBP1- and Cdk2 (show CDK2 Antibodies)-dependent recruitment of Cdc45 (show CDC45 Antibodies) onto replication origins.
Cut5 plays a crucial role in the initial amplification step of the ATR (show ATR Antibodies)-Chk1 (show CHEK1 Antibodies) signaling pathway at the stalled replication fork.
This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands.
DNA topoisomerase 2-binding protein 1
, topoisomerase (DNA) II beta binding protein
, topoisomerase (DNA) II binding protein 1
, dna topoisomerase ii binding protein 1 (IC)
, DNA topoisomerase 2-binding protein 1-like
, DNA topoisomerase II-beta-binding protein 1
, DNA topoisomerase II-binding protein 1
, Cut5-related protein
, DNA topoisomerase 2-binding protein 1-A
, DNA topoisomerase 2-binding protein 1-B
, DNA topoisomerase II-binding protein 1-A
, DNA topoisomerase II-binding protein 1-B