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Topoisomerase (DNA) II Binding Protein 1 (TOPBP1) ELISA Kits

TOPBP1 encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. Additionally we are shipping Topoisomerase (DNA) II Binding Protein 1 Antibodies (68) and Topoisomerase (DNA) II Binding Protein 1 Proteins (3) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Rat TOPBP1 TOPBP1 315969  
Anti-Human TOPBP1 TOPBP1 11073 Q92547
Anti-Mouse TOPBP1 TOPBP1 235559 Q6ZQF0
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More ELISA Kits for Topoisomerase (DNA) II Binding Protein 1 Interaction Partners

Human Topoisomerase (DNA) II Binding Protein 1 (TOPBP1) interaction partners

  1. The innate immune regulator STAT-5 is shown to regulate transcription of the ATR binding factor TopBP1, and this is critical for the induction of the ATR pathway in human papillomavirus-infected keratinocytes.

  2. TOPBP1 physically binds PLK1 (show PLK1 ELISA Kits) and promotes PLK1 (show PLK1 ELISA Kits) kinase-mediated phosphorylation of RAD51 (show RAD51 ELISA Kits) at serine 14, a modification required for RAD51 (show RAD51 ELISA Kits) recruitment to chromatin.

  3. Functional analyses indicat that the expression TopBP1 and Claspin (show CLSPN ELISA Kits) positively affects the survival of brain cancer cells after exposure to radiation.

  4. TopBP1 interacts with BLM to maintain genome stability but is dispensable for preventing BLM degradation.Crucial residues mediating TopBP1-MDC1 (show MDC1 ELISA Kits) interactions identified.

  5. TopBP1 maintains genome integrity in mitosis by controlling chromatin recruitment of SLX4 (show BTBD12 ELISA Kits) and by facilitating unscheduled DNA synthesis.

  6. Findings demonstrate that TopBP1 and ATR are able to inhibit the synthesis of rRNA and to activate nucleolar stress pathway.

  7. TOPBP1 has a role in recruiting TOP2A (show TOP2A ELISA Kits) to ultra-fine anaphase bridges to aid in their resolution

  8. The results suggest that interactions between TopBP1 and E2 and between Brd4 (show BRD4 ELISA Kits) and E2 are required to correctly initiate human papillomavirus 16 DNA replication but are not required for continuing DNA replication.

  9. Phosphorylation of BRIT1 protein coordinates TopBP1 protein recruitment and amplifies ATR signaling in cell DNA damage.

  10. High TopBP1 mRNA and protein expression is associated with endometrial cancer.

Mouse (Murine) Topoisomerase (DNA) II Binding Protein 1 (TOPBP1) interaction partners

  1. Consistent with prior reports, TopBP1 co-localized in discrete nuclear foci and was in complex with papillomavirus E2 protein (show UBE2B ELISA Kits).

  2. The deacetylated form of TopBP1 in SIRT1 (show SIRT1 ELISA Kits) mutant cells repressed replication origin firing, while the acetylated form of TopBP1 lost this function.

  3. Studies identify the SIRT1 (show SIRT1 ELISA Kits)-TopBP1 axis as a key signaling mode in the regulation of the metabolic checkpoint and the DNA damage checkpoint.

  4. TopBP1 is a crucial factor in V(D)J rearrangement during the development of B, T and iNKT cells.

  5. Our data suggest that, unlike the yeast models, the TopBP1-AAD is the major activator of ATR, sustaining cell proliferation and embryonic development

  6. TopBP1 is crucial for maintaining genome integrity in the early progenitors that drive neurogenesis.

  7. Tethering DNA damage checkpoint mediator proteins topoisomerase IIbeta-binding protein 1 (TopBP1) and Claspin (show CLSPN ELISA Kits) to DNA activates ataxia-telangiectasia mutated and RAD3-related (ATR (show ATR ELISA Kits)) phosphorylation of checkpoint kinase 1 (Chk1 (show CHEK1 ELISA Kits)).

  8. TopBP1 deficiency in untransformed mouse and human primary cells induces cellular senescence rather than apoptosis. These results indicate that TopBP1 is essential for cell proliferation and maintenance of chromosomal integrity.

  9. ATR (show ATR ELISA Kits) and TopBP1 monitor meiotic recombination and are required for activation of the meiotic recombination checkpoint

  10. TopBP1 is a c-Abl-interacting protein and a repressor for c-Abl expression

Xenopus laevis Topoisomerase (DNA) II Binding Protein 1 (TOPBP1) interaction partners

  1. TopBP1's C-terminal motif containing a putative nuclear localization signal was required for Importin beta (show KPNB1 ELISA Kits) interaction and that CT100 of Importin beta (show KPNB1 ELISA Kits) was required for TopBP1 interaction.

  2. these findings indicate that WDR18 (show WDR18 ELISA Kits) is a bona fide checkpoint protein and that WDR18 (show WDR18 ELISA Kits) works together with TopBP1 to promote DNA damage checkpoint signaling.

  3. MRN (MRE11 (show MRE11A ELISA Kits)-RAD50 (show RAD50 ELISA Kits)-NBS1) complex has role in ATR (show ATR ELISA Kits) activation via TOPBP1 recruitment.

  4. Cut5 plays an integral role in the recruitment and assembly of the Chk1 (show CHEK1 ELISA Kits) signaling cascade components following DNA damage

  5. Data show that Rad17 (show RAD17 ELISA Kits) mediates the interaction of the Rad9 (show RAD9A ELISA Kits)-Hus1 (show HUS1 ELISA Kits)-Rad1 (show ERCC4 ELISA Kits) (9-1-1) complex with the ATR (show ATR ELISA Kits)-activating protein TopBP1 in Xenopus egg extracts.

  6. Data show that recombinant TopBP1 induces a large increase in the kinase activity of both Xenopus and human ATR (show ATR ELISA Kits)-ATRIP (show ATRIP ELISA Kits).

  7. GEMC1 promotes initiation of chromosomal DNA replication in multicellular organisms by mediating TopBP1- and Cdk2-dependent recruitment of Cdc45 onto replication origins.

  8. Cut5 plays a crucial role in the initial amplification step of the ATR (show ATR ELISA Kits)-Chk1 (show CHEK1 ELISA Kits) signaling pathway at the stalled replication fork.

Topoisomerase (DNA) II Binding Protein 1 (TOPBP1) Antigen Profile

Antigen Summary

This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands.

Gene names and symbols associated with TOPBP1

  • topoisomerase (DNA) II binding protein 1 (Topbp1) antibody
  • topoisomerase (DNA) II binding protein 1 (topbp1) antibody
  • topoisomerase (DNA) II binding protein 1 (TOPBP1) antibody
  • dna topoisomerase ii binding protein 1 (IC) (topbp1) antibody
  • meiosis defective 1 (MEI1) antibody
  • 1110031N14Rik antibody
  • 2810429C13Rik antibody
  • AI256758 antibody
  • cut5 antibody
  • D430026L04Rik antibody
  • F2P24.3 antibody
  • F2P24_3 antibody
  • meiosis defective 1 antibody
  • mKIAA0259 antibody
  • mus101 antibody
  • RGD1562949 antibody
  • top2bp1 antibody
  • TOPBP1 antibody
  • TopBP1-A antibody
  • TopBP1-B antibody
  • Xmus101 antibody
  • XtopBP antibody

Protein level used designations for TOPBP1

DNA topoisomerase 2-binding protein 1 , topoisomerase (DNA) II beta binding protein , topoisomerase (DNA) II binding protein 1 , dna topoisomerase ii binding protein 1 (IC) , DNA topoisomerase 2-binding protein 1-like , DNA topoisomerase II-beta-binding protein 1 , DNA topoisomerase II-binding protein 1 , Cut5-related protein , DNA topoisomerase 2-binding protein 1-A , DNA topoisomerase 2-binding protein 1-B , DNA topoisomerase II-binding protein 1-A , DNA topoisomerase II-binding protein 1-B

315969 Rattus norvegicus
407679 Danio rerio
420694 Gallus gallus
460709 Pan troglodytes
477070 Canis lupus familiaris
540574 Bos taurus
719054 Macaca mulatta
9837136 Ostreococcus tauri
100053011 Equus caballus
100349197 Oryctolagus cuniculus
100380063 Xenopus (Silurana) tropicalis
100403635 Callithrix jacchus
100441644 Pongo abelii
100468359 Ailuropoda melanoleuca
100542278 Meleagris gallopavo
100594594 Nomascus leucogenys
100626645 Sus scrofa
844068 Arabidopsis thaliana
11073 Homo sapiens
235559 Mus musculus
398573 Xenopus laevis
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