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Topoisomerase (DNA) II Binding Protein 1 Proteins (TOPBP1)

TOPBP1 encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. Additionally we are shipping Topoisomerase (DNA) II Binding Protein 1 Antibodies (68) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat TOPBP1 TOPBP1 315969  
TOPBP1 11073 Q92547
TOPBP1 235559 Q6ZQF0
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Top Topoisomerase (DNA) II Binding Protein 1 Proteins at

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Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 49 to 54 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 49 to 54 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days

TOPBP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine)

More Proteins for Topoisomerase (DNA) II Binding Protein 1 (TOPBP1) Interaction Partners

Human Topoisomerase (DNA) II Binding Protein 1 (TOPBP1) interaction partners

  1. The innate immune regulator STAT-5 is shown to regulate transcription of the ATR binding factor TopBP1, and this is critical for the induction of the ATR pathway in human papillomavirus-infected keratinocytes.

  2. TOPBP1 physically binds PLK1 and promotes PLK1 kinase-mediated phosphorylation of RAD51 (show RAD51 Proteins) at serine 14, a modification required for RAD51 (show RAD51 Proteins) recruitment to chromatin.

  3. Functional analyses indicat that the expression TopBP1 and Claspin positively affects the survival of brain cancer cells after exposure to radiation.

  4. TopBP1 interacts with BLM to maintain genome stability but is dispensable for preventing BLM degradation.Crucial residues mediating TopBP1-MDC1 interactions identified.

  5. TopBP1 maintains genome integrity in mitosis by controlling chromatin recruitment of SLX4 and by facilitating unscheduled DNA synthesis.

  6. Findings demonstrate that TopBP1 and ATR are able to inhibit the synthesis of rRNA and to activate nucleolar stress pathway.

  7. TOPBP1 has a role in recruiting TOP2A (show TOP2A Proteins) to ultra-fine anaphase bridges to aid in their resolution

  8. The results suggest that interactions between TopBP1 and E2 and between Brd4 (show BRD4 Proteins) and E2 are required to correctly initiate human papillomavirus 16 DNA replication but are not required for continuing DNA replication.

  9. Phosphorylation of BRIT1 protein coordinates TopBP1 protein recruitment and amplifies ATR signaling in cell DNA damage.

  10. High TopBP1 mRNA and protein expression is associated with endometrial cancer.

Mouse (Murine) Topoisomerase (DNA) II Binding Protein 1 (TOPBP1) interaction partners

  1. Consistent with prior reports, TopBP1 co-localized in discrete nuclear foci and was in complex with papillomavirus E2 protein (show UBE2B Proteins).

  2. The deacetylated form of TopBP1 in SIRT1 (show SIRT1 Proteins) mutant cells repressed replication origin firing, while the acetylated form of TopBP1 lost this function.

  3. Studies identify the SIRT1 (show SIRT1 Proteins)-TopBP1 axis as a key signaling mode in the regulation of the metabolic checkpoint and the DNA damage checkpoint.

  4. TopBP1 is a crucial factor in V(D)J rearrangement during the development of B, T and iNKT cells.

  5. Our data suggest that, unlike the yeast models, the TopBP1-AAD is the major activator of ATR, sustaining cell proliferation and embryonic development

  6. TopBP1 is crucial for maintaining genome integrity in the early progenitors that drive neurogenesis.

  7. Tethering DNA damage checkpoint mediator proteins topoisomerase IIbeta-binding protein 1 (TopBP1) and Claspin to DNA activates ataxia-telangiectasia mutated and RAD3-related (ATR) phosphorylation of checkpoint kinase 1 (Chk1 (show CHEK1 Proteins)).

  8. TopBP1 deficiency in untransformed mouse and human primary cells induces cellular senescence rather than apoptosis. These results indicate that TopBP1 is essential for cell proliferation and maintenance of chromosomal integrity.

  9. ATR and TopBP1 monitor meiotic recombination and are required for activation of the meiotic recombination checkpoint

  10. TopBP1 is a c-Abl-interacting protein and a repressor for c-Abl expression

Xenopus laevis Topoisomerase (DNA) II Binding Protein 1 (TOPBP1) interaction partners

  1. TopBP1's C-terminal motif containing a putative nuclear localization signal was required for Importin beta (show KPNB1 Proteins) interaction and that CT100 (show DPPA2 Proteins) of Importin beta (show KPNB1 Proteins) was required for TopBP1 interaction.

  2. these findings indicate that WDR18 (show WDR18 Proteins) is a bona fide checkpoint protein and that WDR18 (show WDR18 Proteins) works together with TopBP1 to promote DNA damage checkpoint signaling.

  3. MRN (MRE11 (show MRE11A Proteins)-RAD50 (show RAD50 Proteins)-NBS1 (show NLRP2 Proteins)) complex has role in ATR activation via TOPBP1 recruitment.

  4. Cut5 plays an integral role in the recruitment and assembly of the Chk1 (show CHEK1 Proteins) signaling cascade components following DNA damage

  5. Data show that Rad17 (show RAD17 Proteins) mediates the interaction of the Rad9 (show RAD9A Proteins)-Hus1 (show HUS1 Proteins)-Rad1 (9-1-1) complex with the ATR-activating protein TopBP1 in Xenopus egg extracts.

  6. Data show that recombinant TopBP1 induces a large increase in the kinase activity of both Xenopus and human ATR-ATRIP (show ATRIP Proteins).

  7. GEMC1 (show GMNC Proteins) promotes initiation of chromosomal DNA replication in multicellular organisms by mediating TopBP1- and Cdk2 (show CDK2 Proteins)-dependent recruitment of Cdc45 (show CDC45 Proteins) onto replication origins.

  8. Cut5 plays a crucial role in the initial amplification step of the ATR-Chk1 (show CHEK1 Proteins) signaling pathway at the stalled replication fork.

Topoisomerase (DNA) II Binding Protein 1 (TOPBP1) Protein Profile

Protein Summary

This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands.

Gene names and symbols associated with TOPBP1

  • topoisomerase (DNA) II binding protein 1 (Topbp1)
  • topoisomerase (DNA) II binding protein 1 (topbp1)
  • topoisomerase (DNA) II binding protein 1 (TOPBP1)
  • dna topoisomerase ii binding protein 1 (IC) (topbp1)
  • meiosis defective 1 (MEI1)
  • 1110031N14Rik protein
  • 2810429C13Rik protein
  • AI256758 protein
  • cut5 protein
  • D430026L04Rik protein
  • F2P24.3 protein
  • F2P24_3 protein
  • meiosis defective 1 protein
  • mKIAA0259 protein
  • mus101 protein
  • RGD1562949 protein
  • top2bp1 protein
  • TOPBP1 protein
  • TopBP1-A protein
  • TopBP1-B protein
  • Xmus101 protein
  • XtopBP protein

Protein level used designations for TOPBP1

DNA topoisomerase 2-binding protein 1 , topoisomerase (DNA) II beta binding protein , topoisomerase (DNA) II binding protein 1 , dna topoisomerase ii binding protein 1 (IC) , DNA topoisomerase 2-binding protein 1-like , DNA topoisomerase II-beta-binding protein 1 , DNA topoisomerase II-binding protein 1 , Cut5-related protein , DNA topoisomerase 2-binding protein 1-A , DNA topoisomerase 2-binding protein 1-B , DNA topoisomerase II-binding protein 1-A , DNA topoisomerase II-binding protein 1-B

315969 Rattus norvegicus
407679 Danio rerio
420694 Gallus gallus
460709 Pan troglodytes
477070 Canis lupus familiaris
540574 Bos taurus
719054 Macaca mulatta
9837136 Ostreococcus tauri
100053011 Equus caballus
100349197 Oryctolagus cuniculus
100380063 Xenopus (Silurana) tropicalis
100403635 Callithrix jacchus
100441644 Pongo abelii
100468359 Ailuropoda melanoleuca
100542278 Meleagris gallopavo
100594594 Nomascus leucogenys
100626645 Sus scrofa
844068 Arabidopsis thaliana
11073 Homo sapiens
235559 Mus musculus
398573 Xenopus laevis
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