Topoisomerase (DNA) III beta (TOP3B) ELISA Kits

TOP3B encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. Additionally we are shipping TOP3B Antibodies (54) and TOP3B Proteins (4) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human TOP3B TOP3B 8940 O95985
Anti-Mouse TOP3B TOP3B 21976 Q9Z321
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More ELISA Kits for TOP3B Interaction Partners

Human Topoisomerase (DNA) III beta (TOP3B) interaction partners

  1. Top3b proteins from several animals associate with polyribosomes, which are units of mRNA translation, whereas the Top3 (show TOP3A ELISA Kits) homologs from E. coli and yeast lack the association. The Top3b-polyribosome association requires TDRD3 (show TDRD3 ELISA Kits), which directly interacts with Top3beta and is present in animals but not bacteria or yeast.

  2. TOP3B promotes transcription, protects against DNA damage, and reduces the frequency of chromosomal translocations.

  3. the positive regulatory region including the 5'GGAACC3' core element is essential for efficient expression of the DNA topoisomerase III beta gene

Mouse (Murine) Topoisomerase (DNA) III beta (TOP3B) interaction partners

  1. DNA topoisomerase III beta has a role in infertility and aneuploidy

TOP3B Antigen Profile

Antigen Summary

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Alternative splicing of the C-terminus of this gene results in three transcript variants which have distinct tissue specificity\; however, not all variants have been fully described.

Gene names and symbols associated with TOP3B

  • topoisomerase (DNA) III beta (TOP3B) antibody
  • topoisomerase (DNA) III beta (Top3b) antibody
  • TOP3B1 antibody

Protein level used designations for TOP3B

DNA topoisomerase 3-beta-1 , DNA topoisomerase III beta-1 , topoisomerase III beta , Topo III beta

8940 Homo sapiens
21976 Mus musculus
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