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anti-Topoisomerase I Binding, arginine/serine-Rich, E3 Ubiquitin Protein Ligase (TOPORS) Antibodies

TOPORS encodes a nuclear protein which is serine and arginine rich, and contains a RING-type zinc finger domain. Additionally we are shipping TOPORS Proteins (3) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
Anti-Rat TOPORS TOPORS 362501  
Anti-Mouse TOPORS TOPORS 106021 Q80Z37
TOPORS 10210 Q9NS56
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Top anti-TOPORS Antibodies at antibodies-online.com

Showing 10 out of 34 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated IF, IHC (p), ELISA, WB Immunoperoxidase of monoclonal antibody to TOPORS on formalin-fixed paraffin-embedded human lung, adenosquamous cell carcinoma. [antibody concentration 3 ug/ml] Immunofluorescence of monoclonal antibody to TOPORS on HeLa cell. [antibody concentration 10 ug/ml] 100 μg Log in to see 9 Days
$430.00
Details
Human Mouse Un-conjugated EIA, IF, IHC (p), WB 50 μg Log in to see 6 to 8 Days
$566.50
Details
Human Mouse Un-conjugated IF, WB Immunofluorescence of monoclonal antibody to TOPORS on HeLa cell (antibody concentration 10 µg/mL). TOPORS monoclonal antibody (M01), clone 5G11 Western Blot analysis of TOPORS expression in HeLa NE. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged TOPORS is approximately 1 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (37.62 KDa) . 200 μL Log in to see 9 Days
$430.00
Details
Human Mouse Un-conjugated IF, IHC, ELISA, WB 0.05 mg Log in to see 2 to 3 Days
$618.75
Details
Human Mouse Un-conjugated IF, ELISA, WB Detection limit for recombinant GST tagged TOPORS is approximately 1ng/ml as a capture antibody. Immunofluorescence of monoclonal antibody to TOPORS on HeLa cell. [antibody concentration 10 ug/ml] 100 μg Log in to see 9 Days
$430.00
Details
Human Mouse Un-conjugated IF, IHC (p), ELISA, WB Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 8 to 10 Days
$511.50
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (37.99 KDa) . 50 μL Log in to see 9 Days
$298.57
Details
Human Mouse Un-conjugated IF, IHC (p), ELISA, WB 50 μg Log in to see 5 to 6 Days
$611.80
Details

TOPORS Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-TOPORS Antibodies

  1. Human Monoclonal TOPORS Primary Antibody for IF, IHC (p) - ABIN564418 : Hackbarth, Galvez-Peralta, Dai, Loegering, Peterson, Meng, Karnitz, Kaufmann: Mitotic phosphorylation stimulates DNA relaxation activity of human topoisomerase I. in The Journal of biological chemistry 2008 (PubMed)

More Antibodies against TOPORS Interaction Partners

Fruit Fly (Drosophila melanogaster) Topoisomerase I Binding, arginine/serine-Rich, E3 Ubiquitin Protein Ligase (TOPORS) interaction partners

  1. dtopors plays a structural role in spermatocyte lamina that is critical for multiple aspects of meiotic chromosome transmission

  2. Drosophila Topors is a RING finger-containing protein that functions as a ubiquitin-protein isopeptide ligase for the hairy basic helix-loop-helix repressor protein

Mouse (Murine) Topoisomerase I Binding, arginine/serine-Rich, E3 Ubiquitin Protein Ligase (TOPORS) interaction partners

  1. Data suggest a mechanism for the inhibitory effects of Sdc-1 (show SDC1 Antibodies) on cell growth that involves the interaction between the cytoplasmic domain of Sdc-1 (show SDC1 Antibodies) and the SUMO-1 (show SUMO1 Antibodies) E3 ligase, Topors.

  2. These results indicate a unique role for Topors in the maintenance of genomic stability and pericentric heterochromatin, as well as in cellular sensitivity to histone deacetylase (show HDAC1 Antibodies) inhibitors.

  3. NKX3.1 (show NKX3-1 Antibodies) can be ubiquitinated by TOPORS in vitro and in vivo, and overexpression of TOPORS leads to NKX3.1 (show NKX3-1 Antibodies) proteasomal degradation in prostate cancer cells

Human Topoisomerase I Binding, arginine/serine-Rich, E3 Ubiquitin Protein Ligase (TOPORS) interaction partners

  1. P26s4 (show PSMC1 Antibodies) Associates with the C-Terminal Region of TOPORS.

  2. Data suggest that TOPORS plays key role in turnover of H2AX (show H2AFX Antibodies) (H2A histone family, member X protein) depending on the type of oxidative stress/DNA damage; TOPORS may act as an E3 ubiquitin ligase (show MUL1 Antibodies) for histones.

  3. Disturbed flow induces peroxynitrite production and binding to the E3 SUMO (small ubiquitin-like modifier (show SUMO1 Antibodies)) ligase PIASy (show PIAS4 Antibodies) (protein inhibitor of activated STATy).

  4. In photoreceptors, TOPORS localizes primarily to the basal bodies of connecting cilium and in the centrosomes.

  5. Polo-like kinase 1 (Plk1 (show PLK1 Antibodies))-associated phosphorylation of Topors at S718 is essential for nocodazole-induced degradation of Topors.

  6. We present a novel mutation in the TOPORS gene co-segregating with a distinct phenotype of adPRD in a large Norwegian family.

  7. Topors, a p53 (show TP53 Antibodies) and topoisomerase I (show TOP1 Antibodies) binding protein, interacts with the adeno (show ADORA2A Antibodies)-associated virus (AAV-2) Rep78/68 proteins and enhances AAV-2 gene expression

  8. topors localizes in punctate nuclear regions associated with PML (show PML Antibodies) protein nuclear bodies.

  9. Multiple SUMO-1 (show SUMO1 Antibodies) modified forms of Topors could be detected after cotransfection of exogenous SUMO-1 (show SUMO1 Antibodies) and Topors induced the colocalization of a YFP tagged SUMO-1 (show SUMO1 Antibodies) protein in a speckled pattern in the nucleus.

  10. topors functions as a negative regulator of cell growth, and possibly as a tumor suppressor

TOPORS Antigen Profile

Protein Summary

This gene encodes a nuclear protein which is serine and arginine rich, and contains a RING-type zinc finger domain. It is highly expressed in the testis, and functions as an ubiquitin-protein E3 ligase. Mutations in this gene are associated with retinitis pigmentosa type 31. Alternatively spliced transcript variants, encoding different isoforms, have been observed for this locus.

Gene names and symbols associated with TOPORS

  • Topoisomerase I-interacting protein (Topors) antibody
  • topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase (Topors) antibody
  • topoisomerase I binding, arginine/serine-rich (TOPORS) antibody
  • topoisomerase I binding, arginine/serine-rich (topors) antibody
  • topoisomerase I binding, arginine/serine-rich (Topors) antibody
  • topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase (TOPORS) antibody
  • AW105885 antibody
  • CG15104 antibody
  • Dmel\\CG15104 antibody
  • dtopors antibody
  • fi75f04 antibody
  • LUN antibody
  • P53BP3 antibody
  • p53BP3/LUN antibody
  • RP31 antibody
  • TOPORS antibody
  • TP53BPL antibody
  • wu:fi75f04 antibody

Protein level used designations for TOPORS

CG15104-PA , CG15104-PB , Topors-PA , Topors-PB , topoisomerase I-interacting protein , E3 ubiquitin-protein ligase Topors , topoisomerase I binding, arginine/serine-rich , E3 ubiquitin-protein ligase Topors-like , e3 ubiquitin-protein ligase Topors-like , SUMO1-protein E3 ligase Topors , p53-binding protein 3 , p53BP3 , topoisomerase 1-binding RING finger , topoisomerase I-binding RING finger protein , topoisomerase I-binding arginine/serine-rich protein , tumor suppressor p53-binding protein 3

GENE ID SPECIES
37188 Drosophila melanogaster
362501 Rattus norvegicus
427342 Gallus gallus
481577 Canis lupus familiaris
523321 Bos taurus
734040 Xenopus (Silurana) tropicalis
744660 Pan troglodytes
796087 Danio rerio
100409065 Callithrix jacchus
100443889 Pongo abelii
106021 Mus musculus
10210 Homo sapiens
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