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Topoisomerase I Binding, arginine/serine-Rich, E3 Ubiquitin Protein Ligase Proteins (TOPORS)

TOPORS encodes a nuclear protein which is serine and arginine rich, and contains a RING-type zinc finger domain. Additionally we are shipping TOPORS Antibodies (33) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat TOPORS TOPORS 362501  
TOPORS 106021 Q80Z37
TOPORS 10210 Q9NS56
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Top TOPORS Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

TOPORS Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

More Proteins for Topoisomerase I Binding, arginine/serine-Rich, E3 Ubiquitin Protein Ligase (TOPORS) Interaction Partners

Fruit Fly (Drosophila melanogaster) Topoisomerase I Binding, arginine/serine-Rich, E3 Ubiquitin Protein Ligase (TOPORS) interaction partners

  1. dtopors plays a structural role in spermatocyte lamina that is critical for multiple aspects of meiotic chromosome transmission

  2. Drosophila Topors is a RING finger-containing protein that functions as a ubiquitin-protein isopeptide ligase for the hairy basic helix-loop-helix repressor protein

Mouse (Murine) Topoisomerase I Binding, arginine/serine-Rich, E3 Ubiquitin Protein Ligase (TOPORS) interaction partners

  1. Data suggest a mechanism for the inhibitory effects of Sdc-1 (show SDC1 Proteins) on cell growth that involves the interaction between the cytoplasmic domain of Sdc-1 (show SDC1 Proteins) and the SUMO-1 (show SUMO1 Proteins) E3 ligase, Topors.

  2. These results indicate a unique role for Topors in the maintenance of genomic stability and pericentric heterochromatin, as well as in cellular sensitivity to histone deacetylase (show HDAC1 Proteins) inhibitors.

  3. NKX3.1 (show NKX3-1 Proteins) can be ubiquitinated by TOPORS in vitro and in vivo, and overexpression of TOPORS leads to NKX3.1 (show NKX3-1 Proteins) proteasomal degradation in prostate cancer cells

Human Topoisomerase I Binding, arginine/serine-Rich, E3 Ubiquitin Protein Ligase (TOPORS) interaction partners

  1. P26s4 (show PSMC1 Proteins) Associates with the C-Terminal Region of TOPORS.

  2. Data suggest that TOPORS plays key role in turnover of H2AX (show H2AFX Proteins) (H2A histone family, member X protein) depending on the type of oxidative stress/DNA damage; TOPORS may act as an E3 ubiquitin ligase (show MUL1 Proteins) for histones.

  3. Disturbed flow induces peroxynitrite production and binding to the E3 SUMO (small ubiquitin-like modifier (show SUMO1 Proteins)) ligase PIASy (show PIAS4 Proteins) (protein inhibitor of activated STATy).

  4. In photoreceptors, TOPORS localizes primarily to the basal bodies of connecting cilium and in the centrosomes.

  5. Polo-like kinase 1 (Plk1)-associated phosphorylation of Topors at S718 is essential for nocodazole-induced degradation of Topors.

  6. We present a novel mutation in the TOPORS gene co-segregating with a distinct phenotype of adPRD in a large Norwegian family.

  7. Topors, a p53 (show TP53 Proteins) and topoisomerase I (show TOP1 Proteins) binding protein, interacts with the adeno (show ADORA2A Proteins)-associated virus (AAV-2) Rep78/68 proteins and enhances AAV-2 gene expression

  8. topors localizes in punctate nuclear regions associated with PML (show PML Proteins) protein nuclear bodies.

  9. Multiple SUMO-1 (show SUMO1 Proteins) modified forms of Topors could be detected after cotransfection of exogenous SUMO-1 (show SUMO1 Proteins) and Topors induced the colocalization of a YFP tagged SUMO-1 (show SUMO1 Proteins) protein in a speckled pattern in the nucleus.

  10. topors functions as a negative regulator of cell growth, and possibly as a tumor suppressor

TOPORS Protein Profile

Protein Summary

This gene encodes a nuclear protein which is serine and arginine rich, and contains a RING-type zinc finger domain. It is highly expressed in the testis, and functions as an ubiquitin-protein E3 ligase. Mutations in this gene are associated with retinitis pigmentosa type 31. Alternatively spliced transcript variants, encoding different isoforms, have been observed for this locus.

Gene names and symbols associated with TOPORS

  • Topoisomerase I-interacting protein (Topors)
  • topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase (Topors)
  • topoisomerase I binding, arginine/serine-rich (TOPORS)
  • topoisomerase I binding, arginine/serine-rich (topors)
  • topoisomerase I binding, arginine/serine-rich (Topors)
  • topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase (TOPORS)
  • AW105885 protein
  • CG15104 protein
  • Dmel\\CG15104 protein
  • dtopors protein
  • fi75f04 protein
  • LUN protein
  • P53BP3 protein
  • p53BP3/LUN protein
  • RP31 protein
  • TOPORS protein
  • TP53BPL protein
  • wu:fi75f04 protein

Protein level used designations for TOPORS

CG15104-PA , CG15104-PB , Topors-PA , Topors-PB , topoisomerase I-interacting protein , E3 ubiquitin-protein ligase Topors , topoisomerase I binding, arginine/serine-rich , E3 ubiquitin-protein ligase Topors-like , e3 ubiquitin-protein ligase Topors-like , SUMO1-protein E3 ligase Topors , p53-binding protein 3 , p53BP3 , topoisomerase 1-binding RING finger , topoisomerase I-binding RING finger protein , topoisomerase I-binding arginine/serine-rich protein , tumor suppressor p53-binding protein 3

GENE ID SPECIES
37188 Drosophila melanogaster
362501 Rattus norvegicus
427342 Gallus gallus
481577 Canis lupus familiaris
523321 Bos taurus
734040 Xenopus (Silurana) tropicalis
744660 Pan troglodytes
796087 Danio rerio
100409065 Callithrix jacchus
100443889 Pongo abelii
106021 Mus musculus
10210 Homo sapiens
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