anti-Torsin Family 1, Member A (Torsin A) (TOR1A) Antibodies

The protein encoded by TOR1A is a member of the AAA family of adenosine triphosphatases (ATPases), is related to the Clp protease/heat shock family and is expressed prominently in the substantia nigra pars compacta. Additionally we are shipping Torsin Family 1, Member A (Torsin A) Proteins (9) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TOR1A 266606  
TOR1A 1861 O14656
TOR1A 30931 Q9ER39
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Top anti-Torsin Family 1, Member A (Torsin A) Antibodies at antibodies-online.com

Showing 10 out of 65 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Dog Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Rabbit Un-conjugated IHC, WB Immunohistochemical analysis of TorsinA staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated Western blot analysis of TorsinA expression in MCF7 (A), SW480 (B), mouse liver (C) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated WB TOR1A Antibody (C-term)  western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the TOR1A antibody detected the TOR1A protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated WB DYT1 Antibody  western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the DYT1 antibody detected the DYT1 protein (arrow). 0.1 mL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated WB Western blot analysis of extracts of SH-SY5Y cell line, using TOR1A antibody. 100 μL Log in to see 16 Days
$323.13
Details
Human Rabbit Un-conjugated ICC, IF Immunocytochemistry/Immunofluorescence: Torsin A Antibody  - Staining of human cell line MCF7 shows localization to nuclear membrane & vesicles. 100 μL Log in to see 10 to 13 Days
$439.69
Details
Human Rabbit Un-conjugated WB   0.1 mL Log in to see 8 to 11 Days
$447.56
Details
Human Rabbit Alexa Fluor 350 IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details
Human Rabbit Alexa Fluor 488 IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details

TOR1A Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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More Antibodies against Torsin Family 1, Member A (Torsin A) Interaction Partners

Human Torsin Family 1, Member A (Torsin A) (TOR1A) interaction partners

  1. A comparison of these structures shows, in atomic detail, the subtle differences in TorsinADeltaE-LULL1 (show TOR1AIP2 Antibodies) activator interactions that separate the healthy from the diseased state.

  2. found that human Torsin1A and human FMRP (show FMR1 Antibodies) were present in the same protein complexes, suggesting that this phenomenon is evolutionarily conserved

  3. The significant association of rs1182 and rs1801968 TOR1A variants was found in the development of focal dystonia and writer's cramp respectively.

  4. This study demonstrated that whole-exome sequencing show reveled TOR1A mutation with early-onset generalized dystonia.

  5. This study showed that the Phosphodiesterase-10A (show PDE10A Antibodies) Inverse Changes in Striatopallidal and Striatoentopeduncular Pathways of a Transgenic Mouse Model of DYT1 Dystonia.

  6. Genetic screening targeted at currently known disease-causing mutations in TOR1A, THAP1 (show THAP1 Antibodies), and TUBB4 (show TUBB3 Antibodies) appears to have low diagnostic yield in sporadic spasmodic dysphonia. In our cohort, only 2 patients tested positive for novel/rare variants in THAP1 (show THAP1 Antibodies).

  7. there might not be an association between TOR1A or THAP1 (show THAP1 Antibodies) and patients with adult-onset primary focal dystonia

  8. Our patient and three other reported carriers of non-c.907_909delGAG-mutations within the first three exons of TOR1A showed similar phenotypes of adult-onset focal or segmental cervical dystonia

  9. the common rs2296793 and rs3842225 SNPs of TOR1A do not play a major role in cervical dystonia in a Chinese population.

  10. Certain TOR1A genotypes may be regarded as factors predisposing to focal and segmental dystonia.

Mouse (Murine) Torsin Family 1, Member A (Torsin A) (TOR1A) interaction partners

  1. Study linked the genetic defect of reduced torsinA expression in a DYT1 related mouse model to a maladaptive response of the striatal dopaminergic system after a peripheral nerve lesion and to the manifestation of dystonia-like movements

  2. The nuclear envelope-localized AAA (show AAAS Antibodies)+ (ATPase (show DNAH8 Antibodies) associated with various cellular activities) torsinA (TA) and its activator, the inner nuclear membrane protein lamina-associated polypeptide 1 (show CYP Antibodies) (LAP1 (show TRAF3 Antibodies)), are required for rearward nuclear movement.

  3. Authors find no effect of this anatomic-specific expression of the DYT1 genotype.

  4. The data suggest that LULL1 (show TOR1AIP2 Antibodies) oligomerizes to engage and transiently disassemble torsinA oligomers, and is thereby positioned to transduce cytoplasmic signals to the inner nuclear membrane through torsinA.

  5. These findings demonstrate that dorsal dorsal striatal large cholinergic interneurons have a unique requirement for torsinA function during striatal maturation, and link abnormalities of these cells to dystonic-like movements.

  6. maintaining an appropriate torsinA level is important to sustain normal motor performance, synaptic transmission and plasticity

  7. Dyt1 KI mice exhibit decreased striatal dopamine receptor 1 binding activity and D1R (show DRD1 Antibodies) protein levels, suggesting the alteration of the direct pathway. We developed a novel motor skill transfer test for mice and found deficits in Dyt1 KI mice.

  8. cellular and molecular framework for how impaired torsinA function selectively disrupts neural circuits and raise the possibility that discrete foci of neurodegeneration may contribute to the pathogenesis of DYT1 dystonia

  9. Results reveal subtle structural changes of the cerebellum that are similar to those reported for the basal ganglia in the DYT1 knock-in mouse model.

  10. the mutation only slightly increases the excitability of striatal GABAergic neurons in DYT1 dystonia.

Pig (Porcine) Torsin Family 1, Member A (Torsin A) (TOR1A) interaction partners

  1. This work reports the cloning and analysis of the porcine (Sus scrofa) homologue of TOR1A.

Torsin Family 1, Member A (Torsin A) (TOR1A) Antigen Profile

Protein Summary

The protein encoded by this gene is a member of the AAA family of adenosine triphosphatases (ATPases), is related to the Clp protease/heat shock family and is expressed prominently in the substantia nigra pars compacta. Mutations in this gene result in the autosomal dominant disorder, torsion dystonia 1.

Gene names and symbols associated with TOR1A

  • torsin family 1, member A (Tor1a) antibody
  • torsin family 1, member A (torsin A) (TOR1A) antibody
  • torsin family 1, member A (torsin A) (Tor1a) antibody
  • DQ2 antibody
  • DYT1 antibody
  • torsinA antibody

Protein level used designations for TOR1A

dystonia 1, torsion (autosomal dominant , dystonia 1, torsion (autosomal dominant; torsin A) , torsin A , torsin-1A , dystonia 1 protein , torsin family 1 member A

GENE ID SPECIES
266606 Rattus norvegicus
1861 Homo sapiens
30931 Mus musculus
100125953 Sus scrofa
533699 Bos taurus
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