Torsin Family 1, Member A (Torsin A) Proteins (TOR1A)

The protein encoded by TOR1A is a member of the AAA family of adenosine triphosphatases (ATPases), is related to the Clp protease/heat shock family and is expressed prominently in the substantia nigra pars compacta. Additionally we are shipping Torsin Family 1, Member A (Torsin A) Antibodies (65) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat TOR1A TOR1A 266606  
TOR1A 1861 O14656
TOR1A 30931 Q9ER39
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Top Torsin Family 1, Member A (Torsin A) Proteins at antibodies-online.com

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Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
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HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
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Yeast Cricetus cricetus His tag   1 mg Log in to see 60 to 71 Days
$2,713.33
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HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 2 to 3 Days
$382.86
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HOST_Escherichia coli (E. coli) Human T7 tag,His tag   100 μg Log in to see 15 to 18 Days
$704.00
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HOST_Escherichia coli (E. coli) Mouse T7 tag,His tag   100 μg Log in to see 15 to 18 Days
$736.00
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TOR1A Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Mouse (Murine) ,
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More Proteins for Torsin Family 1, Member A (Torsin A) (TOR1A) Interaction Partners

Human Torsin Family 1, Member A (Torsin A) (TOR1A) interaction partners

  1. The significant association of rs1182 and rs1801968 TOR1A variants was found in the development of focal dystonia and writer's cramp respectively.

  2. This study demonstrated that whole-exome sequencing show reveled TOR1A mutation with early-onset generalized dystonia.

  3. This study showed that the Phosphodiesterase-10A (show PDE10A Proteins) Inverse Changes in Striatopallidal and Striatoentopeduncular Pathways of a Transgenic Mouse Model of DYT1 Dystonia.

  4. Genetic screening targeted at currently known disease-causing mutations in TOR1A, THAP1 (show THAP1 Proteins), and TUBB4 (show TUBB3 Proteins) appears to have low diagnostic yield in sporadic spasmodic dysphonia. In our cohort, only 2 patients tested positive for novel/rare variants in THAP1 (show THAP1 Proteins).

  5. there might not be an association between TOR1A or THAP1 (show THAP1 Proteins) and patients with adult-onset primary focal dystonia

  6. Our patient and three other reported carriers of non-c.907_909delGAG-mutations within the first three exons of TOR1A showed similar phenotypes of adult-onset focal or segmental cervical dystonia

  7. the common rs2296793 and rs3842225 SNPs of TOR1A do not play a major role in cervical dystonia in a Chinese population.

  8. Certain TOR1A genotypes may be regarded as factors predisposing to focal and segmental dystonia.

  9. DYT1 mutations are associated with dystonia disorders

  10. TorA(DeltaE) in Drosophila brains may activate the UPR and increase the expression of HSP22 to compensate for the toxic effects

Mouse (Murine) Torsin Family 1, Member A (Torsin A) (TOR1A) interaction partners

  1. Study linked the genetic defect of reduced torsinA expression in a DYT1 related mouse model to a maladaptive response of the striatal dopaminergic system after a peripheral nerve lesion and to the manifestation of dystonia-like movements

  2. The nuclear envelope-localized AAA (show AAAS Proteins)+ (ATPase associated with various cellular activities) torsinA (TA) and its activator, the inner nuclear membrane protein lamina-associated polypeptide 1 (LAP1 (show TRAF3 Proteins)), are required for rearward nuclear movement.

  3. Authors find no effect of this anatomic-specific expression of the DYT1 genotype.

  4. The data suggest that LULL1 (show TOR1AIP2 Proteins) oligomerizes to engage and transiently disassemble torsinA oligomers, and is thereby positioned to transduce cytoplasmic signals to the inner nuclear membrane through torsinA.

  5. These findings demonstrate that dorsal dorsal striatal large cholinergic interneurons have a unique requirement for torsinA function during striatal maturation, and link abnormalities of these cells to dystonic-like movements.

  6. maintaining an appropriate torsinA level is important to sustain normal motor performance, synaptic transmission and plasticity

  7. Dyt1 KI mice exhibit decreased striatal dopamine receptor 1 binding activity and D1R (show DRD1 Proteins) protein levels, suggesting the alteration of the direct pathway. We developed a novel motor skill transfer test for mice and found deficits in Dyt1 KI mice.

  8. cellular and molecular framework for how impaired torsinA function selectively disrupts neural circuits and raise the possibility that discrete foci of neurodegeneration may contribute to the pathogenesis of DYT1 dystonia

  9. Results reveal subtle structural changes of the cerebellum that are similar to those reported for the basal ganglia in the DYT1 knock-in mouse model.

  10. the mutation only slightly increases the excitability of striatal GABAergic neurons in DYT1 dystonia.

Pig (Porcine) Torsin Family 1, Member A (Torsin A) (TOR1A) interaction partners

  1. This work reports the cloning and analysis of the porcine (Sus scrofa) homologue of TOR1A.

Torsin Family 1, Member A (Torsin A) (TOR1A) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the AAA family of adenosine triphosphatases (ATPases), is related to the Clp protease/heat shock family and is expressed prominently in the substantia nigra pars compacta. Mutations in this gene result in the autosomal dominant disorder, torsion dystonia 1.

Gene names and symbols associated with TOR1A

  • torsin family 1, member A (Tor1a)
  • torsin family 1, member A (torsin A) (TOR1A)
  • torsin family 1, member A (torsin A) (Tor1a)
  • DQ2 protein
  • DYT1 protein
  • torsinA protein

Protein level used designations for TOR1A

dystonia 1, torsion (autosomal dominant , dystonia 1, torsion (autosomal dominant; torsin A) , torsin A , torsin-1A , dystonia 1 protein , torsin family 1 member A

GENE ID SPECIES
266606 Rattus norvegicus
1861 Homo sapiens
30931 Mus musculus
100125953 Sus scrofa
533699 Bos taurus
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