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The protein encoded by TLK1 is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. Additionally we are shipping Tousled-Like Kinase 1 Proteins (6) and Tousled-Like Kinase 1 Kits (1) and many more products for this protein.
Showing 10 out of 112 products:
Human Polyclonal TLK1 Primary Antibody for EIA - ABIN117936
Remy, Perney, Bourat, Ramos, Marty, Cabaniols, Durand, Quenet, Blanc: [Amyloidosis of the gallbladder. An unusual localization] in Gastroentérologie clinique et biologique 1995
Show all 8 references for ABIN117936
Human Polyclonal TLK1 Primary Antibody for EIA, IHC (p) - ABIN360576
Cabaniols, Ravichandran, Roche: Phosphorylation of SNAP-23 by the novel kinase SNAK regulates t-SNARE complex assembly. in Molecular biology of the cell 2000
Show all 4 references for ABIN360576
Human Polyclonal TLK1 Primary Antibody for WB - ABIN2787642
Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: Large-scale mapping of human protein-protein interactions by mass spectrometry. ... in 2007
Human Polyclonal TLK1 Primary Antibody for ELISA, WB - ABIN1452102
Yamakawa, Kameoka, Hashimoto, Yoshitake, Nishikawa, Tanihara, Date: cDNA cloning and chromosomal mapping of genes encoding novel protein kinases termed PKU-alpha and PKU-beta, which have nuclear localization signal. in Gene 1998
Human Polyclonal TLK1 Primary Antibody for IHC (p), WB - ABIN392685
Takayama, Kokuryo, Yokoyama, Ito, Nagino, Hamaguchi, Senga: Silencing of Tousled-like kinase 1 sensitizes cholangiocarcinoma cells to cisplatin-induced apoptosis. in Cancer letters 2010
TLK-1 contributes to chromosome condensation and segregation;TLK-1 functions in cytokinesis by localizing AIR-2 to the midzone microtubules.
Tousled-like kinase (TLK-1) contributes to chromosome segregation as a substrate and regulator of the Aurora B kinase AIR-2.
Data indicate Tousled-like kinases (TLK1) phosphorylation has an impact on cell cycle proteins Asf1a (show ASF1A Antibodies) and Asf1b (show ASF1B Antibodies) function.
Tousled-like kinase-dependent phosphorylation of Rad9 (show RAD9A Antibodies) plays a role in cell cycle progression and G2/M checkpoint exit.
Adenoviral delivery of Tousled kinase protects salivary glands against ionizing radiation damage.
Silencing of TLK1 enhanced DNA damage induced by cisplatin treatment, suggesting that TLK1 plays a pivotal role for the repair of cisplatin-induced DNA damage.
ASF1 (show SRSF1 Antibodies) cellular levels are tightly controlled by distinct pathways and provide a molecular mechanism for post-translational regulation of dASF1 (show SRSF1 Antibodies) and hASF1a (show ASF1A Antibodies) by TLK (show TLK2 Antibodies) kinases.
we show that Chk1 (show CHEK1 Antibodies) is essential for the suppression of TLK (show TLK2 Antibodies) activity after replication block, but that ATR (show ANTXR1 Antibodies), Chk2 (show CHEK2 Antibodies) and BRCA1 are dispensable for TLK (show TLK2 Antibodies) suppression.
Both eIF4E (show EIF4E Antibodies) and TLK1B are elevated in breast cancer specimens but not in benign breast specimens from noncancer patients. Degree of TLK1B elevation is correlated with degree of IF4E (show EIF4E2 Antibodies) overexpression.
In addition, it could be demonstrated that increasing the Tlk1 activity in HT1080 (show CDC123 Antibodies) cells by forced Tlk1 overexpression leads to an increased phosphorylation of endogenous p68 (show ANXA6 Antibodies).
Studies provide evidence for TLK1B-mediated phosphorylation of Asf1 (show SRSF1 Antibodies) triggering DNA repair.
Our data suggest that human PKU-beta/TLK1 plays an important role in chromosome integrity via the regulation of myosin II dynamics by phosphorylating MRLC during mitosis.
The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene.
tousled-like kinase 1
, pKU-beta protein kinase
, serine/threonine-protein kinase tousled-like 1-B
, tousled-like kinase 1-B
, SNARE protein kinase SNAK
, serine threonine protein kinase
, serine/threonine-protein kinase tousled-like 1