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The Tousled-like kinases, first described in Arabidopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly.[supplied by OMIM, Apr 2004].. Additionally we are shipping Tousled-Like Kinase 2 Antibodies (84) and many more products for this protein.
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Human TLK2 Protein expressed in Baculovirus infected Insect Cells - ABIN2004351
Silljé, Nigg: Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases. in Current biology : CB 2001
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Tlk2 promotes Asf1A (show ASF1A Proteins) function during the DNA damage response in G2 to allow for proper restoration of chromatin structure at the break site and subsequent recovery from the arrest.
Results show that TLK2 overexpression correlates with increased genome-wide copy number aberrations in breast cancer cells, impairs cell-cycle checkpoint signaling in response to DNA damage.
TLK2 plays a role in Kaposi's sarcoma-associated herpesvirus reactivation.
ASF1 (show SRSF1 Proteins) cellular levels are tightly controlled by distinct pathways and provide a molecular mechanism for post-translational regulation of dASF1 (show SRSF1 Proteins) and hASF1a (show ASF1A Proteins) by TLK kinases.
The Tousled-like kinases, first described in Arabidopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly.
tousled-like kinase 2
, Serine/threonine-protein kinase tousled-like 2
, serine/threonine kinase
, serine/threonine-protein kinase tousled-like 2
, pKU-alpha protein kinase
, protein kinase U-alpha