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Plays a role in the negative regulation of NF-kappa-B signaling at the basal level by modulating transcriptional activity of NF-kappa-B on its target gene promoters. Additionally we are shipping TCEAL7 Antibodies (6) and many more products for this protein.
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Human TCEAL7 Protein expressed in Escherichia coli (E. coli) - ABIN1098326
Lafferty-Whyte, Bilsland, Hoare, Burns, Zaffaroni, Cairney, Keith: TCEAL7 inhibition of c-Myc activity in alternative lengthening of telomeres regulates hTERT expression. in Neoplasia (New York, N.Y.) 2010
Show all 2 references for ABIN1098326
Our study suggests that TCEAL7 might serve as a candidate tumor suppressor and a potential prognostic biomarker in gastric carcinogenesis.
alteration of TCEAL7 expression levels in recombination-based alternative lengthening of telomeres and telomerase-positive cells affects hTERT expression
TCEAL7 in the negative regulation of NF-kappaB (show NFKB1 Proteins) signaling at the basal level by modulating transcriptional activity of NF-kappaB (show NFKB1 Proteins) on its target gene promoters in ovarian cells.
TCEAL7 is a cell death regulatory protein that is frequently inactivated in ovarian cancers, and may function as a tumor suppressor.
A role for candidate tumor-suppressor gene TCEAL7 in the regulation of c-Myc (show MYC Proteins) activity, cyclin D1 (show CCND1 Proteins) levels and cellular transformation is reported.
TCEAL7 polymorphisms may play a role in the development of invasive serous ovarian cancers.
The studies support the hypothesis that MRFs transactivate Tceal7 gene expression and promote muscle differentiation during muscle development and regeneration.
These data implicate human TCEAL7 as a cell death regulatory protein that is frequently inactivated in ovarian cancers, and suggest that it may function as a tumor suppressor.
Plays a role in the negative regulation of NF-kappa-B signaling at the basal level by modulating transcriptional activity of NF-kappa-B on its target gene promoters. Associates with cyclin D1 promoter containing Myc E-box sequence and transcriptionally represses cyclin D1 expression. Regulates telomerase reverse transcriptase expression and telomerase activity in both ALT (alternative lengthening of telomeres)and telomerase-positive cell lines (By similarity).
TCEA-like protein 7
, transcription elongation factor A protein-like 7
, transcription elongation factor S-II protein-like 7