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Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. Additionally we are shipping Transcription Elongation Factor SPT5 Antibodies (51) and Transcription Elongation Factor SPT5 Kits (3) and many more products for this protein.
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Spt5 interacts both physically and genetically with the Polycomb (show CBX2 Proteins) Group (PcG) protein Pleiohomeotic (Pho)
We show that SPT5 interacts directly with MSL1 in vitro and is required downstream of MSL complex recruitment, providing the first mechanistic data corroborating the elongation model of dosage compensation.
Spt5 acts both positively and negatively on transcription in vivo during heat shock induction.
SPT5-like protein emerged in plants as a facultative RNA polymerase elongation factor (show TSFM Proteins).[SPT5]
Spt5 accumulation at variable genes distinguishes somatic hypermutation in germinal center B cells from ex vivo-activated cells.
our findings indicate that Spt4 (show SUPT4H1 Proteins) and Spt5 have essential functions in the DNA repair phase of immunoglobulin class switch recombination.
Study reports that Spt5, a factor normally associated with stalled or paused Pol II, is required for class switch recombination.
the positive function of Foggy/Spt5 is required for gata1 (show GATA1 Proteins) expression during zebrafish embryonic hematopoiesis.
RNA polymerase II elongation repression is critically dependent on the C-terminus of Spt5
The elongation factors Pandora/Spt6 and Foggy/Spt5 promote transcription in the zebrafish embryo.
spt 5-dependent transcript elongation is required cell-autonomously for a complex cell migration
Spt5 as a dual regulator of transcription elongation in vivo; a small but diverse set of target genes critically dependent on Spt5 during development.
The mobile C-terminal region of DSIF is located near exiting RNA, where it can recruit factors for RNA processing.
OGA (show MGEA5 Proteins) is physically associated with the known RNA polymerase II (pol II) pausing/elongation factors SPT5 and TRIM28-KAP1-TIF1beta (show TRIM28 Proteins), and a purified OGA (show MGEA5 Proteins)-SPT5-TIF1beta (show TRIM28 Proteins) complex has elongation properties.
A transcription-independent effect of tumor necrosis factor alpha (show TNF Proteins) on RNA splicing, mediated by Spt5.
SPT5 contributes to the up-regulation of hTERT expression and colonic tumor development.
Data indicate that the Plus3 domain of the Rtf1 (show RTF1 Proteins) subunit mediates Paf1C recruitment to genes by binding a repeating domain within the phosphorylated elongation factor (show TSFM Proteins) Spt5.
DSIF Is Selectively Required for mRNA Splicing and Export of NF-kappaB (show NFKB1 Proteins) Target Genes.
crystal structure of hSpt4 (show SUPT4H1 Proteins) in complex with the dimerization region of hSpt5
phosphorylated by P-TEFb (show CCNT1 Proteins) kinase during HIV-1 transcription in Tat (show TAT Proteins)/TAR (show RBM8A Proteins) dependent manner
hSpt5 function in transcription regulation and mRNA capping is essential for a subset of cellular and viral genes and may not be required for global gene expression.
Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV- 1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences.
, transcription elongation factor SPT5
, transcription elongation factor Spt5
, transcription elongation factor spt5
, potential RNA Pol II transcription elongation factor
, DRB sensitivity-inducing factor large subunit
, DSIF large subunit
, suppressor of Ty 5 homolog
, protein foggy
, transcription elongation regulator foggy
, DRB sensitivity-inducing factor 160 kDa subunit
, DSIF p160
, Tat-cotransactivator 1 protein