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Transcription Factor 12 Proteins (TCF12)

The protein encoded by TCF12 is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. Additionally we are shipping TCF12 Antibodies (83) and TCF12 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TCF12 6938 Q99081
TCF12 21406 Q61286
TCF12 25720 P51514
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Top TCF12 Proteins at antibodies-online.com

Showing 7 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Primates His tag   1 mg Log in to see 56 to 66 Days
$2,361.33
Details
Yeast Mesocricetus auratus His tag   1 mg Log in to see 56 to 66 Days
$3,223.00
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$4,060.83
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 9 to 11 Days
$229.85
Details

TCF12 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for Transcription Factor 12 (TCF12) Interaction Partners

Human Transcription Factor 12 (TCF12) interaction partners

  1. Two novel translocations leading to the inactivation of RUNX1 (show RUNX1 Proteins) and its partners SIN3A (show SIN3A Proteins) and TCF12 in myeloid leukemia (show BCL11A Proteins).

  2. Studies suggest that transcription factor 12 (TCF12) should be included in level 2 genetic testing.

  3. show that these mutations compromise TCF12 transcriptional activity and are associated with a more aggressive tumour type

  4. several familial cases of coronal synostosis associated with mutations in TCF12

  5. In t(8;21) leukemia cells, the two E proteins, HEB and E2A (show TCF3 Proteins), function as components of the stable AML1 (show RUNX1 Proteins)-ETO (show RUNX1T1 Proteins)-containing transcription factor complex (AETFC). The AETFC components cooperatively regulate gene expression and contribute to leukemogenesis.

  6. haploinsufficiency of TCF12 causes coronal synostosis in humans and that severe bilateral coronal synostosis occ (show TWIST1 Proteins)urs in mice with 50% of the wild-type dosage of both the T (show TWIST1 Proteins)cf12 and Twist1 genes highlights the key role of TCF12 acting with TWIST1.

  7. the CD91 (show LRP1 Proteins)/IKK (show CHUK Proteins)/NF-kappaB (show NFKB1 Proteins) signaling cascade is involved in secreted HSP90alpha (show HSP90AA2 Proteins)-induced TCF12 expression, leading to E-cadherin (show CDH1 Proteins) down-regulation and enhanced CRC (show CALR Proteins) cell migration/invasion

  8. TCF12 functioned as a transcriptional repressor of E-cadherin (show CDH1 Proteins) and its overexpression was significantly correlated with the occurrence of CRC (show CALR Proteins) metastasis.

  9. HEB and E2A (show TCF3 Proteins)-bind the SCA motif at regions overlapping SMAD2 (show SMAD2 Proteins)/3 and FOXH1 (show FOXH1 Proteins)

  10. As a first exploitation of this unique cohort, we identify three novel candidate dyslexia genes, ZNF280D and TCF12 at 15q21, and PDE7B (show PDE7B Proteins) at 6q23.3, by molecular mapping of the familial translocation with the 15q21 breakpoint.

Mouse (Murine) Transcription Factor 12 (TCF12) interaction partners

  1. HEB is a fundamental link between Nodal signalling, the derepression of a specific class of poised promoters during differentiation, and lineage specification in mouse embryonic stem cells

  2. severe bilateral coronal synostosis occurs in mice with 50% of the wild-type dosage of both the Tcf12 and Twist1 (show TWIST1 Proteins) genes highlights the key role of TCF12 acting with TWIST1 (show TWIST1 Proteins) in the normal development of the coronal sutures

  3. Deficiency in the E proteins, E2A (show TCF3 Proteins) and HEB, led to increased frequency of terminally differentiated effector KLRG1 (show KLRG1 Proteins)(hi) CD8 (show CD8A Proteins)(+) T cells in mice during infection, and decreased generation of longer-lived memory-precursor cells during the immune response.

  4. Deletion of HEB and E2A (show TCF3 Proteins) in DP thymocytes specifically blocked the development of CD4 (show CD4 Proteins)(+) lineage T cells. Furthermore, deletion of the E protein inhibitors Id2 and Id3 (show ID3 Proteins) allowed CD4 (show CD4 Proteins)(+) T cell development but blocked CD8 (show CD8A Proteins)(+) lineage development.

  5. the earliest event in B-cell specification involves the induction of FOXO1 (show FOXO1 Proteins) expression and requires the combined activities of E2A (show TCF3 Proteins) and HEB

  6. These results showed a new set of interactions between HEB, Notch1 (show NOTCH1 Proteins), and GATA3 (show GATA3 Proteins) that regulate the T-cell fate choice in developing thymocytes.

  7. Developmental progression of fetal HEB(-/-) precursors to the pre-T-cell stage is restored by HEBAlt.

  8. HEB is a specific and essential factor in T-cell development and in the generation of the iNKT cell lineage.

  9. the dosage of HEB determines pT alpha (show PTCRA Proteins) gene expression in immature T cells

  10. the Tcf12 gene may be involved in the control of proliferating neural stem cells and progenitor cells

TCF12 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. This encoded protein is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Gene names and symbols associated with TCF12

  • transcription factor 12 (TCF12)
  • transcription factor 12 (LOC100339415)
  • transcription factor 12 (tcf12)
  • transcription factor 12 (Tcf12)
  • transcription factor 12 (HTF4, helix-loop-helix transcription factors 4) (tcf12)
  • A130037E08Rik protein
  • ALF1 protein
  • bHLHb20 protein
  • CRS3 protein
  • HEB protein
  • HEBAlt protein
  • HsT17266 protein
  • HTF-4 protein
  • HTF4 protein
  • ME1 protein
  • REB protein
  • SCBPA protein
  • TCF12 protein
  • wu:fb74g05 protein
  • wu:fc43e06 protein
  • zgc:85956 protein
  • zgc:110341 protein

Protein level used designations for TCF12

transcription factor 12 , transcription factor 12 (HTF4, helix-loop-helix transcription factors 4) , DNA-binding protein HTF4 , E-box-binding protein , TCF-12 , class B basic helix-loop-helix protein 20 , helix-loop-helix transcription factor 4 , transcription factor HTF-4 , class A helix-loop-helix transcription factor ME1 , SCBP alpha , SCBP-alpha , salivary-specific cAMP response element-binding protein alpha , TF12 , basic helix-loop-helix protein , class A helix-loop-helix transcription factor GE1 , XE1.1

GENE ID SPECIES
453466 Pan troglodytes
100339415 Oryctolagus cuniculus
100460448 Pongo abelii
100553875 Anolis carolinensis
100603993 Nomascus leucogenys
6938 Homo sapiens
509039 Bos taurus
21406 Mus musculus
25720 Rattus norvegicus
407985 Danio rerio
396334 Gallus gallus
100684199 Canis lupus familiaris
399451 Xenopus laevis
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