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The protein encoded by TCF12 is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. Additionally we are shipping TCF12 Proteins (7) and many more products for this protein.
Showing 10 out of 88 products:
Cow (Bovine) Polyclonal TCF12 Primary Antibody for WB - ABIN2780487
Lazrek, Goffard, Schanen, Karquel, Bocket, Lion, Devaux, Hedouin, Gosset, Hober: Detection of hepatitis C virus antibodies and RNA among medicolegal autopsy cases in Northern France. in Diagnostic microbiology and infectious disease 2006
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Chicken Polyclonal TCF12 Primary Antibody for WB - ABIN2774659
Wissmüller, Kosian, Wolf, Finzsch, Wegner: The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors. in Nucleic acids research 2006
Show all 2 references for ABIN2774659
Human Polyclonal TCF12 Primary Antibody for EIA, WB - ABIN783743
Murre, McCaw, Vaessin, Caudy, Jan, Jan, Cabrera, Buskin, Hauschka, Lassar: Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence. in Cell 1989
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Human Polyclonal TCF12 Primary Antibody for EIA, WB - ABIN955126
Schotte, Dontje, Nagasawa, Yasuda, Bakker, Spits, Blom: Synergy between IL-15 and Id2 promotes the expansion of human NK progenitor cells, which can be counteracted by the E protein HEB required to drive T cell development. in Journal of immunology (Baltimore, Md. : 1950) 2010
HEB may be involved in GBM cell proliferation, as HEB silencing reduced proliferation in cells cultured as monolayers or neurospheres. Furthermore, the results suggested a potential role for HEB in the maintenance of GBM stem cells, as HEB silencing affected the differentiation capacity of cells.
Two novel translocations leading to the inactivation of RUNX1 (show RUNX1 Antibodies) and its partners SIN3A (show SIN3A Antibodies) and TCF12 in myeloid leukemia (show BCL11A Antibodies).
Studies suggest that transcription factor 12 (TCF12) should be included in level 2 genetic testing.
show that these mutations compromise TCF12 transcriptional activity and are associated with a more aggressive tumour type
several familial cases of coronal synostosis associated with mutations in TCF12
In t(8;21) leukemia cells, the two E proteins, HEB and E2A (show TCF3 Antibodies), function as components of the stable AML1 (show RUNX1 Antibodies)-ETO (show RUNX1T1 Antibodies)-containing transcription factor complex (AETFC). The AETFC components cooperatively regulate gene expression and contribute to leukemogenesis.
haploinsufficiency of TCF12 causes coronal synostosis in humans and that severe bilateral coronal synostosis occ (show TWIST1 Antibodies)urs in mice with 50% of the wild-type dosage of both the T (show TWIST1 Antibodies)cf12 and Twist1 genes highlights the key role of TCF12 acting with TWIST1.
the CD91 (show LRP1 Antibodies)/IKK (show CHUK Antibodies)/NF-kappaB (show NFKB1 Antibodies) signaling cascade is involved in secreted HSP90alpha (show HSP90AA2 Antibodies)-induced TCF12 expression, leading to E-cadherin (show CDH1 Antibodies) down-regulation and enhanced CRC (show CALR Antibodies) cell migration/invasion
TCF12 functioned as a transcriptional repressor of E-cadherin (show CDH1 Antibodies) and its overexpression was significantly correlated with the occurrence of CRC (show CALR Antibodies) metastasis.
HEB and E2A (show TCF3 Antibodies)-bind the SCA motif at regions overlapping SMAD2 (show SMAD2 Antibodies)/3 and FOXH1 (show FOXH1 Antibodies)
HEB (show FREM1 Antibodies) is a fundamental link between Nodal signalling, the derepression of a specific class of poised promoters during differentiation, and lineage specification in mouse embryonic stem cells
severe bilateral coronal synostosis occurs in mice with 50% of the wild-type dosage of both the Tcf12 and Twist1 (show TWIST1 Antibodies) genes highlights the key role of TCF12 acting with TWIST1 (show TWIST1 Antibodies) in the normal development of the coronal sutures
Deficiency in the E proteins, E2A (show TCF3 Antibodies) and HEB (show FREM1 Antibodies), led to increased frequency of terminally differentiated effector KLRG1 (show KLRG1 Antibodies)(hi) CD8 (show CD8A Antibodies)(+) T cells in mice during infection, and decreased generation of longer-lived memory-precursor cells during the immune response.
Deletion of HEB (show FREM1 Antibodies) and E2A (show TCF3 Antibodies) in DP thymocytes specifically blocked the development of CD4 (show CD4 Antibodies)(+) lineage T cells. Furthermore, deletion of the E protein inhibitors Id2 and Id3 (show ID3 Antibodies) allowed CD4 (show CD4 Antibodies)(+) T cell development but blocked CD8 (show CD8A Antibodies)(+) lineage development.
the earliest event in B-cell specification involves the induction of FOXO1 (show FOXO1 Antibodies) expression and requires the combined activities of E2A (show TCF3 Antibodies) and HEB (show FREM1 Antibodies)
These results showed a new set of interactions between HEB (show FREM1 Antibodies), Notch1 (show NOTCH1 Antibodies), and GATA3 (show GATA3 Antibodies) that regulate the T-cell fate choice in developing thymocytes.
Developmental progression of fetal HEB (show FREM1 Antibodies)(-/-) precursors to the pre-T-cell stage is restored by HEBAlt.
HEB (show FREM1 Antibodies) is a specific and essential factor in T-cell development and in the generation of the iNKT cell lineage.
the dosage of HEB (show FREM1 Antibodies) determines pT alpha (show PTCRA Antibodies) gene expression in immature T cells
the Tcf12 gene may be involved in the control of proliferating neural stem cells and progenitor cells
The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. This encoded protein is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
transcription factor 12
, transcription factor 12 (HTF4, helix-loop-helix transcription factors 4)
, DNA-binding protein HTF4
, E-box-binding protein
, class B basic helix-loop-helix protein 20
, helix-loop-helix transcription factor 4
, transcription factor HTF-4
, class A helix-loop-helix transcription factor ME1
, SCBP alpha
, salivary-specific cAMP response element-binding protein alpha
, basic helix-loop-helix protein
, class A helix-loop-helix transcription factor GE1