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TCF3 encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. Additionally we are shipping TCF3 Proteins (7) and TCF3 Kits (4) and many more products for this protein.
Showing 10 out of 140 products:
Human Polyclonal TCF3 Primary Antibody for FACS, IHC (p) - ABIN657912
Hirose, Inukai, Kikuchi, Furukawa, Ikawa, Kawamoto, Oram, Göttgens, Kiyokawa, Miyagawa, Okita, Akahane, Zhang, Kuroda, Honna, Kagami, Goi, Kurosawa, Look, Matsui, Inaba, Sugita: Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19). in Blood 2010
Show all 5 references for ABIN657912
Human Polyclonal TCF3 Primary Antibody for EIA, IHC (p) - ABIN500879
Gribble, Kim, Bonner, Wang, Dorsky: Tcf3 inhibits spinal cord neurogenesis by regulating sox4a expression. in Development (Cambridge, England) 2009
Show all 4 references for ABIN500879
Human Monoclonal TCF3 Primary Antibody for ELISA, FACS - ABIN2869482
Firulli, Hadzic, McDaid, Firulli: The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex regulation of function. in The Journal of biological chemistry 2000
Show all 3 references for ABIN2869482
Human Polyclonal TCF3 Primary Antibody for IHC, ELISA - ABIN1533624
Kamps, Murre, Sun, Baltimore: A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL. in Cell 1990
Show all 3 references for ABIN1533624
Human Polyclonal TCF3 Primary Antibody for IHC, ELISA - ABIN1533168
Nourse, Mellentin, Galili, Wilkinson, Stanbridge, Smith, Cleary: Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor. in Cell 1990
Show all 3 references for ABIN1533168
Human Polyclonal TCF3 Primary Antibody for IHC, ELISA - ABIN1532141
Grimwood, Gordon, Olsen, Terry, Schmutz, Lamerdin, Hellsten, Goodstein, Couronne, Tran-Gyamfi, Aerts, Altherr, Ashworth, Bajorek, Black, Branscomb, Caenepeel, Carrano, Caoile, Chan, Christensen et al.: The DNA sequence and biology of human chromosome 19. ... in Nature 2004
Show all 3 references for ABIN1532141
Human Monoclonal TCF3 Primary Antibody for FACS, ELISA - ABIN1724729
Snider, Thirlwell, Miller, Moon, Groudine, Tapscott: Inhibition of Tcf3 binding by I-mfa domain proteins. in Molecular and cellular biology 2001
Show all 2 references for ABIN1724729
Chicken Polyclonal TCF3 Primary Antibody for WB - ABIN2780485
Amemiya-Kudo, Oka, Ide, Matsuzaka, Sone, Yoshikawa, Yahagi, Ishibashi, Osuga, Yamada, Murase, Shimano: Sterol regulatory element-binding proteins activate insulin gene promoter directly and indirectly through synergy with BETA2/E47. in The Journal of biological chemistry 2005
Our data suggest that E2A antagonism of PU.1 activity contributes to its ability to commit multipotential hematopoietic progenitors to the lymphoid lineages.
E47 is a novel substrate of PAK5 (show PAK6 Antibodies), and PAK5 (show PAK6 Antibodies)-mediated phosphorylation of E47 promotes epithelial-mesenchymal transition. High expression of phospho-E47 was associated with an aggressive phenotype of colon cancer and metastasis.
We observed significant enrichment of the neuroactive ligand-receptor interaction pathway in TCF3-PBX1 (show PBX1 Antibodies) as well as an enrichment of genes involved in immunity and infection pathways in ETV6 (show ETV6 Antibodies)-RUNX1 (show RUNX1 Antibodies) subtype
Over expression of E47 reprograms human pancreatic cancer cells to a quiescent acinar state with reduced tumorigenic potential.
Drug response profiling of matched patient-derived xenografts revealed a distinct profile for TCF3-HLF (show EPAS1 Antibodies) ALL with resistance to conventional chemotherapeutics but sensitivity to glucocorticoids.
When intensive chemotherapy was used, the TCF3-PBX1 (show PBX1 Antibodies) was associated with a favorable outcome in childhood pre-B ALL.
Inhibitor of differentiation 4 (ID4 (show ID4 Antibodies)) acts as an inhibitor of ID-1 (show ID1 Antibodies), -2 and -3 and promotes basic helix loop helix (bHLH) E47 DNA binding and transcriptional activity.
Data show that microRNAs miR (show MLXIP Antibodies)-155 and miR-16 (show GDE1 Antibodies) downregulate activation-induced cytidine deaminase (show AICDA Antibodies) (AID) and transcription factor E47 in B Cells through binding of the 3'-untranslated regions.
These results indicate that a dynamic interplay of TCF (show HNF4A Antibodies) transcription factors governs MYC (show MYC Antibodies) gene expression in colorectal cancers.
TCF3 is a novel susceptibility locus for Hodgkin lymphoma.
Conditional expression of E2A-HLF (show HLF Antibodies) induces B-cell precursor death and myeloproliferative-like disease in knock-in mice.
Upregulation of E12/E47 by HBx ultimately and concomitant repression of E-cadherin (show CDH1 Antibodies) expression led to epithelial-mesenchymal transition in human hepatocytes.
Mechanistically, E47 repressed the expression of several astrocyte-specific genes in adult NSPCs.
Tcf3 (show TCF7L1 Antibodies) is upregulated in skin wounds and Tcf3 (show TCF7L1 Antibodies) overexpression accelerates keratinocyte migration and skin wound healing.
Loss and gain of function analyses combined with in vivo studies in syngeneic breast cancer models demonstrate the participation of LOXL2 (show LOXL3 Antibodies) and E47 in tumor growth and their requirement for lung metastasis.
Tcf3 (show TCF7L1 Antibodies) has a role in repressing Wnt (show WNT2 Antibodies)-beta-catenin (show CTNNB1 Antibodies) signaling and maintaining neural stem cell population during neocortical development
the role of Tcf3 (show TCF7L1 Antibodies) in cell-fate decision is more complex than previously appreciated and is highly dependent on cellular context
Id2 represses E2A-mediated activation of IL-10 (show IL10 Antibodies) expression in T cells.
transcription factor E2A binds to the UNG2 (show UNG Antibodies) promoter and represses UNG2 (show UNG Antibodies) expression.
pre-BCR (show BCR Antibodies) signaling downregulates several components of the recombination machinery, including RAG1 (show RAG1 Antibodies), RAG2 (show RAG2 Antibodies), and PAX5 (show PAX5 Antibodies), through calmodulin (show Calm2 Antibodies) inhibition of E2A.
Data indicte that Tcf-1 (show HNF1A Antibodies) and Lef-1 (show LEF1 Antibodies) exhibit a function in the axis induction assay, which is lacking in Tcf-3 and -4.
This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1\;19), with PBX1), childhood leukemia (t(19\;19), with TFPT) and acute leukemia (t(12\;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9.
transcription factor E2-alpha
, transcription factor 3
, VDR interacting repressor
, class B basic helix-loop-helix protein 21
, helix-loop-helix protein HE47
, immunoglobulin transcription factor 1
, kappa-E2-binding factor
, negative vitamin D response element-binding protein
, transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
, transcription factor ITF-1
, vitamin D receptor-interacting repressor
, immunoglobulin enhancer-binding factor E12/E47
, transcription factor A1
, transcription factor E2a
, pancreas specific transcription factor 1c
, transcription regulator Pan
, transcription factor XE12/XE47
, class A basic helix-loop-helix transcription factor G12
, helix-loop-helix protein E12
, helix-loop-helix protein E47
, transcription factor 7-like 1 (T-cell specific, HMG-box)
, transcription factor 7-like 1