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Transcription Factor 3 (E2A Immunoglobulin Enhancer Binding Factors E12/E47) Proteins (TCF3)

TCF3 encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. Additionally we are shipping TCF3 Antibodies (137) and TCF3 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TCF3 6929 P15923
TCF3 21423 P15806
TCF3 171046 P21677
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Top TCF3 Proteins at antibodies-online.com

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,881.17
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 9 to 11 Days
$229.85
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

TCF3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for Transcription Factor 3 (E2A Immunoglobulin Enhancer Binding Factors E12/E47) (TCF3) Interaction Partners

Human Transcription Factor 3 (E2A Immunoglobulin Enhancer Binding Factors E12/E47) (TCF3) interaction partners

  1. E47 is a novel substrate of PAK5 (show PAK6 Proteins), and PAK5 (show PAK6 Proteins)-mediated phosphorylation of E47 promotes epithelial-mesenchymal transition. High expression of phospho-E47 was associated with an aggressive phenotype of colon cancer and metastasis.

  2. We observed significant enrichment of the neuroactive ligand-receptor interaction pathway in TCF3-PBX1 (show PBX1 Proteins) as well as an enrichment of genes involved in immunity and infection pathways in ETV6 (show ETV6 Proteins)-RUNX1 (show RUNX1 Proteins) subtype

  3. Over expression of E47 reprograms human pancreatic cancer cells to a quiescent acinar state with reduced tumorigenic potential.

  4. Drug response profiling of matched patient-derived xenografts revealed a distinct profile for TCF3-HLF (show EPAS1 Proteins) ALL with resistance to conventional chemotherapeutics but sensitivity to glucocorticoids.

  5. When intensive chemotherapy was used, the TCF3-PBX1 (show PBX1 Proteins) was associated with a favorable outcome in childhood pre-B ALL.

  6. Inhibitor of differentiation 4 (ID4 (show ID4 Proteins)) acts as an inhibitor of ID-1 (show ID1 Proteins), -2 and -3 and promotes basic helix loop helix (bHLH) E47 DNA binding and transcriptional activity.

  7. Data show that microRNAs miR (show MLXIP Proteins)-155 and miR-16 (show GDE1 Proteins) downregulate activation-induced cytidine deaminase (show AICDA Proteins) (AID) and transcription factor E47 in B Cells through binding of the 3'-untranslated regions.

  8. These results indicate that a dynamic interplay of TCF (show HNF4A Proteins) transcription factors governs MYC (show MYC Proteins) gene expression in colorectal cancers.

  9. TCF3 is a novel susceptibility locus for Hodgkin lymphoma.

  10. our data suggest a collaborative action between autophagy and ubiquitination in the degradation of E2A/Pbx1 (show PBX1 Proteins), thereby revealing a novel strategy for targeted preventive or treatment therapy on the pediatric ALL.

Mouse (Murine) Transcription Factor 3 (E2A Immunoglobulin Enhancer Binding Factors E12/E47) (TCF3) interaction partners

  1. Conditional expression of E2A-HLF (show HLF Proteins) induces B-cell precursor death and myeloproliferative-like disease in knock-in mice.

  2. Upregulation of E12/E47 by HBx ultimately and concomitant repression of E-cadherin (show CDH1 Proteins) expression led to epithelial-mesenchymal transition in human hepatocytes.

  3. Mechanistically, E47 repressed the expression of several astrocyte-specific genes in adult NSPCs.

  4. Tcf3 (show TCF7L1 Proteins) is upregulated in skin wounds and Tcf3 (show TCF7L1 Proteins) overexpression accelerates keratinocyte migration and skin wound healing.

  5. Loss and gain of function analyses combined with in vivo studies in syngeneic breast cancer models demonstrate the participation of LOXL2 (show LOXL3 Proteins) and E47 in tumor growth and their requirement for lung metastasis.

  6. Tcf3 (show TCF7L1 Proteins) has a role in repressing Wnt (show WNT2 Proteins)-beta-catenin (show CTNNB1 Proteins) signaling and maintaining neural stem cell population during neocortical development

  7. the role of Tcf3 (show TCF7L1 Proteins) in cell-fate decision is more complex than previously appreciated and is highly dependent on cellular context

  8. Id2 represses E2A-mediated activation of IL-10 (show IL10 Proteins) expression in T cells.

  9. transcription factor E2A binds to the UNG2 (show UNG Proteins) promoter and represses UNG2 (show UNG Proteins) expression.

  10. pre-BCR (show BCR Proteins) signaling downregulates several components of the recombination machinery, including RAG1 (show RAG1 Proteins), RAG2 (show RAG2 Proteins), and PAX5 (show PAX5 Proteins), through calmodulin (show Calm2 Proteins) inhibition of E2A.

Xenopus laevis Transcription Factor 3 (E2A Immunoglobulin Enhancer Binding Factors E12/E47) (TCF3) interaction partners

  1. Data indicte that Tcf-1 (show HNF1A Proteins) and Lef-1 (show LEF1 Proteins) exhibit a function in the axis induction assay, which is lacking in Tcf-3 and -4.

TCF3 Protein Profile

Protein Summary

This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1\;19), with PBX1), childhood leukemia (t(19\;19), with TFPT) and acute leukemia (t(12\;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9.

Gene names and symbols associated with TCF3

  • transcription factor 3b (tcf3b)
  • transcription factor 3 (TCF3)
  • transcription factor 3 (Tcf3)
  • transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) (tcf3)
  • transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) (TCF3)
  • transcription factor 7-like 1 (T-cell specific, HMG-box) (Tcf7l1)
  • A1 protein
  • AA408400 protein
  • ALF2 protein
  • AW209082 protein
  • bhlhb21 protein
  • e2a protein
  • E12 protein
  • E12/E47 protein
  • E47 protein
  • G12 protein
  • itf1 protein
  • ME2 protein
  • Pan1 protein
  • Pan2 protein
  • TCF-3 protein
  • Tcf3 protein
  • tcf3a protein
  • TCF7L1 protein
  • tcfe2a protein
  • vdir protein
  • xtcf-3 protein
  • xtcf3 protein
  • zgc:113045 protein

Protein level used designations for TCF3

transcription factor E2-alpha , transcription factor 3 , VDR interacting repressor , class B basic helix-loop-helix protein 21 , helix-loop-helix protein HE47 , immunoglobulin transcription factor 1 , kappa-E2-binding factor , negative vitamin D response element-binding protein , transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) , transcription factor ITF-1 , vitamin D receptor-interacting repressor , TCF-3 , immunoglobulin enhancer-binding factor E12/E47 , transcription factor A1 , transcription factor E2a , pancreas specific transcription factor 1c , transcription regulator Pan , transcription factor XE12/XE47 , class A basic helix-loop-helix transcription factor G12 , helix-loop-helix protein E12 , helix-loop-helix protein E47 , transcription factor 7-like 1 (T-cell specific, HMG-box) , transcription factor 7-like 1

GENE ID SPECIES
664768 Danio rerio
6929 Homo sapiens
21423 Mus musculus
171046 Rattus norvegicus
379355 Xenopus laevis
395146 Gallus gallus
485079 Canis lupus familiaris
530616 Bos taurus
312451 Rattus norvegicus
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