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Transcription Factor A, Mitochondrial Proteins (TFAM)

TFAM encodes a key mitochondrial transcription factor containing two high mobility group motifs. Additionally we are shipping TFAM Antibodies (138) and TFAM Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TFAM 7019 Q00059
TFAM 21780 P40630
TFAM 83474 Q91ZW1
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Top TFAM Proteins at antibodies-online.com

Showing 10 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 10 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Human His tag,GST tag 100 μg Log in to see 11 to 13 Days
$803.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag,GST tag 100 μg Log in to see 11 to 13 Days
$950.40
Details
HOST_Escherichia coli (E. coli) Rat His tag,GST tag 100 μg Log in to see 11 to 13 Days
$968.00
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,491.50
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,498.83
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   10 μg Log in to see 3 to 4 Days
$364.64
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$983.48
Details

TFAM Proteins by Origin and Source

Origin Expressed in Conjugate
Human
,
Mouse (Murine)
,
Rat (Rattus) ,
,

Top referenced TFAM Proteins

  1. Human TFAM Protein expressed in Escherichia coli (E. coli) - ABIN667339 : Aquilano, Vigilanza, Baldelli, Pagliei, Rotilio, Ciriolo: Peroxisome proliferator-activated receptor gamma co-activator 1alpha (PGC-1alpha) and sirtuin 1 (SIRT1) reside in mitochondria: possible direct function in mitochondrial biogenesis. in The Journal of biological chemistry 2010 (PubMed)
    Show all 2 references for ABIN667339

More Proteins for Transcription Factor A, Mitochondrial (TFAM) Interaction Partners

Human Transcription Factor A, Mitochondrial (TFAM) interaction partners

  1. Results showed that TFAM formed oligomers in mitochondria by in situ chemical cross-linking and suggested the importance of the dimerization of TFAM molecules in the distribution of mtDNA in cells.

  2. Report failed upregulation of TFAM protein and mitochondrial DNA in oxidatively deficient fibers in skeletal muscle of chronic obstructive pulmonary disease patients.

  3. Data show that mtTFA proteins are highly expressed in cancer and drug-resistant cells compared to normal cells, and the mtTFA expression is upregulated by signals of oxidative and DNA damage stress in cancer cells. [review]

  4. TFAM overexpression suppressed mitoROS and their upregulation in rat cardiomyocytes.

  5. TFAM dimerization enhances mitochondrial DNA compaction by promoting looping of the DNA.

  6. The combination of strong mtTFA expression and a high survivin (show BIRC5 Proteins) index may predict a poor prognosis in patients with pancreatic ductal adenocarcinoma

  7. expression of PGC1alpha and TFAM varies between ovarian carcinoma subtypes; clear-cell carcinoma consists of undetectability of PGC1alpha/TFAM, and low ERalpha (show ESR1 Proteins)/Ki-67 (show MKI67 Proteins). high-grade serous carcinomas had a converse state of PGC1alpha/TFAM, ERalpha (show ESR1 Proteins) positivity and high Ki-67 (show MKI67 Proteins) index

  8. Methylation of TFAM promoters changed 2 days after gastric bypass.

  9. These data disclose a novel mechanism by which ERK1/2 regulates mitochondrial function through direct phosphorylation of TFAM.

  10. Data suggest that miitochondrial transcription factor A (show GTF3A Proteins) (mtTFA) may be a novel target for the treatment of pancreatic ductal adenocarcinoma (PDAC).

Pig (Porcine) Transcription Factor A, Mitochondrial (TFAM) interaction partners

  1. TFAM may exert a critical role in porcine gametogenesis and preimplantation embryo development.

Cow (Bovine) Transcription Factor A, Mitochondrial (TFAM) interaction partners

  1. Our results suggest that TFAM plays an important role in lipid metabolism and may be a strong candidate gene for obesity in mammals.

  2. de novo mtTFA expression associated with mitochondrial biogenesis activation & high levels of nuclear respiratory factor-1 (show NRF1 Proteins) mRNA from oocyte stage onwards argue for essential function of these factors during the first steps of bovine embryogenesis.

Mouse (Murine) Transcription Factor A, Mitochondrial (TFAM) interaction partners

  1. TFAM binds to RNA-containing 4-way junctions but does not bind appreciably to RNA hairpins, internal loops, or linear RNA:DNA hybrids.

  2. Data show that mitochondrial transcription factor A (TFAM) packages single mitochondrial DNA (mtDNA) molecules.

  3. There was upregulation of mtDNA and TFAM in 6-wk diabetic mice, suggesting that TFAM activation could be a therapeutic strategy to treat peripheral neuropathy.

  4. This study demonistrated that Tfam gene inactive patkinsin disease cause dopamine loss and circadian rhythm disorder.

  5. Mitochondrial transcription factor A, an endogenous danger signal, promotes TNFalpha (show TNF Proteins) release via RAGE (show AGER Proteins)- and TLR9 (show TLR9 Proteins)-responsive plasmacytoid dendritic cells.

  6. overexpression of TFAM can restore mitochondrial function to normal levels in NYGGF4 (show PID1 Proteins)-overexpressing adipocytes

  7. Acute exercise induces tumour suppressor protein p53 (show TP53 Proteins) translocation to the mitochondria and promotes a p53 (show TP53 Proteins)-Tfam-mitochondrial DNA complex in skeletal muscle.

  8. Data indicate that TFAM-deficient keratinocytes failed to generate mitochondria-derived reactive oxygen species, and prevented the transmission of Notch (show NOTCH1 Proteins) and beta-catenin (show CTNNB1 Proteins) signals for epidermal differentiation and hair follicle development.

  9. The reduction of mitochondrial transcription factor A (TFAM) in adipose tissue increases mitochondria oxidation capacity due to complex I deficiency and greater uncoupling.

  10. Data suggest that microRNA 494 regulates mitochondrial biogenesis by down-regulating mtTFA (mitochondrial transcription factor A) and Foxj3 (forkhead box J3 protein) during myocyte differentiation and skeletal muscle adaptation to physical exercise.

TFAM Protein Profile

Protein Summary

This gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimer's and Parkinson's diseases. There are pseudogenes for this gene on chromosomes 6, 7, and 11. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with TFAM

  • transcription factor A, mitochondrial (TFAM)
  • transcription factor A, mitochondrial (tfam)
  • transcription factor A, mitochondrial (Tfam)
  • AI661103 protein
  • Hmgts protein
  • MGC153358 protein
  • MTTF1 protein
  • Mttfa protein
  • mttfa-A protein
  • TCF6 protein
  • TCF6L1 protein
  • TCF6L2 protein
  • TCF6L3 protein
  • tsHMG protein
  • xl-mtTFA protein
  • zgc:153358 protein

Protein level used designations for TFAM

transcription factor A, mitochondrial , HMG box mitochondrial transcription factor , mitochondrial transcription factor 1 , mitochondrial transcription factor A , transcription factor 6 , transcription factor 6-like 1 , transcription factor 6-like 2 (mitochondrial transcription factor) , transcription factor 6-like 3 , mtTFA , transcription factor 6-like 2 , TS-HMG , testis-specific HMG-box protein m-tsHMG , testis-specific high mobility group protein

GENE ID SPECIES
373888 Gallus gallus
394385 Xenopus laevis
571106 Danio rerio
7019 Homo sapiens
488989 Canis lupus familiaris
397279 Sus scrofa
510059 Bos taurus
21780 Mus musculus
83474 Rattus norvegicus
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