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The protein encoded by TFAP2C is a sequence-specific DNA-binding transcription factor involved in the activation of several developmental genes.
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Mouse (Murine) Polyclonal TFAP2C Primary Antibody for WB - ABIN2778628
Jäger, Friedrichs, Heim, Büttner, Schorle: Dual role of AP-2gamma in ErbB-2-induced mammary tumorigenesis. in Breast cancer research and treatment 2005
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Higher TFAP2C protein expression correlates with poor overall survival after 10 years of diagnosis in ERalpha (show ESR1 Antibodies)-positive breast cancer.
TFAP2C has an important role in regulated luminal-specific genes and may be a viable therapeutic target in breast cancer.
ShRNA knockdown of AP-2gamma in neuroblastoma (show ARHGEF16 Antibodies) cells results in significant inhibit of cell proliferation.
Knockdown of TFAP2C or RET (show RET Antibodies) inhibited activation of ERK (show EPHB2 Antibodies) and AKT (show AKT1 Antibodies) in MCF-7 cells. Knockdown of TFAP2C, which controls ER (estrogen receptor (show ESR1 Antibodies)) and RET (show RET Antibodies), had a greater effect on cell growth than either RET (show RET Antibodies) or ER alone.
role for TFAP2C in melanoma via its regulation of ECM1 (show ECM1 Antibodies)
TFAP2C amplification and overexpression represents a genetic dependency in ERBB2 (show ERBB2 Antibodies)+ve breast cancer.
TFAP2C regulates expression of the RET proto-oncogene (show RET Antibodies) through five AP-2 (show GTF3A Antibodies) regulatory sites in the RET (show RET Antibodies) promoter.
Results demonstrate that TFAP2C regulates the expression of GPX1 (show GPX1 Antibodies), which influences the redox state and sensitivity to oxidative stress induced (show SQSTM1 Antibodies) by peroxides.
ESDN (show DCBLD2 Antibodies) and AP-2g expression is lower in thick melanomas, it is associated with unfavourable histo-pathological parameters (increased vascularity, vascular invasion and mitoses) and correlates with a shorter DFS (show FST Antibodies) like for AP-2a.
demonstrated that while TFAP2C and Myc (show MYC Antibodies) can downregulate the CDKN1A promoter independently, KDM5B (show KDM5B Antibodies) acts as a corepressor dependent on the other two proteins
TFAP2C in trophoblasts controls proliferation by repressing Cdkn1a (show CDKN1A Antibodies) and activating the MAPK (show MAPK1 Antibodies) pathway, further supporting differentiation of glycogen (show GYS1 Antibodies) cells by activating the AKT (show AKT1 Antibodies) pathway
these findings indicate that a reduction in the gene dosage of placental Tfap2c leads to morphological changes in the labyrinth at midgestation
TFAP2C regulates tumorigenesis, cell growth and survival in HER2 (show ERBB2 Antibodies)-amplified breast cancer through transcriptional regulation of EGFR (show EGFR Antibodies).
Transcription factor AP-2gamma induces early Cdx2 (show CDX2 Antibodies) expression and represses HIPPO signaling to specify the trophectoderm lineage.
we characterize the cis (show CISH Antibodies)-regulatory organization of a large genomic locus consisting of Tfap2c and Bmp7 (show BMP7 Antibodies). We show that this locus is structurally partitioned into two distinct domains by the constitutive action of a discrete transition zone
mice with a heterozygous deletion of the TFAP2C target gene Nanos3 (show NANOS3 Antibodies) are also prone to develop teratomas. These data highlight TFAP2C as a critical and dose-sensitive regulator of germ cell fate.
Tcfap2c is not required for Oct4 (show POU5F1 Antibodies) silencing in mouse blastocysts, but may be necessary for the maintenance of Oct4 (show POU5F1 Antibodies) expression during the 8 cell-to-morula transition.
critical roles for AP-2 (show TFAP2A Antibodies) activity in retinogenesis, delineating the overlapping expression patterns of Tcfap2a (show TFAP2A Antibodies), Tcfap2b (show TFAP2B Antibodies), and Tcfap2c in the neural retina, and revealing a redundant requirement for Tcfap2a (show TFAP2A Antibodies) and Tcfap2b (show TFAP2B Antibodies) in horizontal and amacrine cell development
An important role for TCFAP2C, SMARCA4 (show SMARCA4 Antibodies), and EOMES (show EOMES Antibodies) in TS cell self-renewal.
Data suggest that Tcfap2c and Cdx2 (show CDX2 Antibodies) cooperate to override the pluripotency program and establish the extraembryonic trophoblast maintenance program in murine embryos.
The protein encoded by this gene is a sequence-specific DNA-binding transcription factor involved in the activation of several developmental genes. The encoded protein can act as either a homodimer or heterodimer with other family members and is induced during retinoic acid-mediated differentiation. It plays a role in the development of the eyes, face, body wall, limbs, and neural tube.
activating enhancer binding protein 2 gamma
, activator protein 2 gamma
, activating enhancer-binding protein 2 gamma
, estrogen receptor factor 1
, transcription factor AP-2 gamma
, transcription factor AP-2 gamma (activating enhancer-binding protein 2 gamma)
, transcription factor ERF-1
, stimulated by retinoic acid gene 2