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Transcription Factor E3 Proteins (TFE3)

The microphthalmia transcription factor/transcription factor E (MITF-TFE) family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors includes four family members: MITF, TFE3, TFEB and TFEC. Additionally we are shipping TFE3 Antibodies (103) and TFE3 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TFE3 7030 P19532
Rat TFE3 TFE3 317376  
TFE3 209446 Q64092
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Top TFE3 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Sf-9 Cells Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$460.85
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

TFE3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,
Mouse (Murine)

More Proteins for Transcription Factor E3 (TFE3) Interaction Partners

Human Transcription Factor E3 (TFE3) interaction partners

  1. CT features including diameter, boundary, attenuation, nature, and circular calcification of the tumor, combined with demographic information and symptoms, may be useful to differentiate Xp11.2 RCC (show XRCC1 Proteins) from different subtypes of PRCC (show PRCC Proteins).

  2. TFEB (show TFEB Proteins) and TFE3 are novel components of the integrated stress response

  3. validates the utility of TFE3 break-apart fluorescence in situ hybridization on formalin-fixed paraffin-embedded tissue sections for diagnosis and confirmation of Xp11.2 translocation RCCs and alveolar soft part sarcoma

  4. Studies indicate that alveolar soft part sarcoma showed a specific chromosomal alteration, der (show GDF3 Proteins)(17)t(X:17)(p11 (show S100A10 Proteins):q25), resulting in the fusion of the TFE3 transcription factor gene (Xp11) with alveolar soft part sarcoma critical region 1 (ASPSCR1 (show ASPSCR1 Proteins)) at 17q25.

  5. TMED6-COG8 (show COG8 Proteins) chimera might act as a novel diagnostic marker in TFE3 translocation renal cell carcinoma (show MOK Proteins).

  6. We report a case of RCC (show XRCC1 Proteins) with Xp11.2 translocation in a 17 year old boy who is a survivor of stage 4 neuroblastoma (show ARHGEF16 Proteins) 13 years earlier.

  7. Case Report: renal carcinoma associated with Xp11.2 translocations/ TFE3 gene fusions diagnosed using urine cytology.

  8. Renal cell carcinoma (show MOK Proteins) (RCC (show XRCC1 Proteins)) associated with Xp11.2 translocation/TFE3 gene fusion (Xp11.2 RCC (show XRCC1 Proteins)) was introduced as a genetically distinct entity into the World Health Organization classification of renal neoplasms in 2004.

  9. TFE3-GASE pathway is one of the regulatory pathways of the mammalian Golgi stress response

  10. PSF/SFPQ is a very common gene fusion partner in TFE3 rearrangement-associated perivascular epithelioid cell tumors (PEComas) and melanotic Xp11 translocation renal cancers.

Mouse (Murine) Transcription Factor E3 (TFE3) interaction partners

  1. TFEB (show TFEB Proteins) and TFE3 are novel components of the integrated stress response

  2. Tfe3 is a critical transcription factor that regulates Pgc-1alpha gene expression in myotubes

  3. A conditional expression in mice of the fusion gene ASPSCR1 (show ASPSCR1 Proteins)-TFE3 from human alveolar soft part sarcoma (ASPS (show DARS Proteins)) generated a model that recapitulates the human tumor histologically and by expression profile.

  4. Data from transgenic mice suggest Tfe3 controls lipid metabolism in adipose tissue (white, WAT; brown, BAT (show BAAT Proteins)); TFE3 appears to be regulated by diet; up-regulation of TFE3 may inhibit expression of lipolysis genes in WAT and thermogenesis genes in BAT (show BAAT Proteins).

  5. These findings indicated that TFE3 has a regulatory role in myoblast differentiation, and that transcriptional suppression of myogenin (show MYOG Proteins) expression may be part of the mechanism of action.

  6. Machinery regulating exit of embryonic stem cells from pluripotency is ill defined; Flcn (show FLCN Proteins) with its interaction partners Fnip1 and Fnip2 (show FNIP2 Proteins) drives differentiation by restricting nuclear localization and activity of the bHLH transcription factor (show MSGN1 Proteins) Tfe3.

  7. TFE3 and Galpha (show SUCLG1 Proteins)(16) are up-regulated under pathologic conditions and are involved in a novel mechanism of transcriptional regulation via the relocalization and activation of Galpha (show SUCLG1 Proteins)(16).

  8. FLCN (show FLCN Proteins) tumor suppressor gene inactivation induces TFE3 transcriptional activity by increasing its nuclear localization

  9. TFE3 and TFEB (show TFEB Proteins) regulate E-cadherin (show CDH1 Proteins) and WT1 (show WT1 Proteins) expression

  10. IRS2 (show IRS2 Proteins), HK2 (show HK2 Proteins) and INSIG1 are direct targets of TFE3

TFE3 Protein Profile

Protein Summary

The microphthalmia transcription factor/transcription factor E (MITF-TFE) family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors includes four family members: MITF, TFE3, TFEB and TFEC. The TEF3 protein encoded by this gene activates transcription through binding to the muE3 motif of the immunoglobulin heavy-chain enhancer. The TFEC protein forms heterodimers with the TEF3 protein and inhibits TFE3-dependent transcription activation. The TEF3 protein interacts with transcription regulators such as E2F3, SMAD3, and LEF-1, and is involved in TGF-beta-induced transcription, playing important roles in cell growth, proliferation, and osteoclast and macrophage differentiation. The TFE3 protein also activates hepatic IRS-2 gene, and induces hexokinase II (HK2) and insulin-induced gene 1 (INSIG1)\; it participates in insulin signaling and could be a therapeutic target for diabetes. This gene is also involved in chromosomal translocations, resulting in different fusion gene products in papillary renal cell carcinomas and alveolar soft part sarcomas, such as PRCC-TFE3, RCC17-TFE3, PSF-TFE3, NonO (p54nrb)-TFE3 and ASPL-TFE3.

Gene names and symbols associated with Transcription Factor E3 Proteins (TFE3)

  • transcription factor binding to IGHM enhancer 3 (TFE3)
  • transcription factor binding to IGHM enhancer 3 (Tfe3)
  • transcription factor binding to IGHM enhancer 3 (tfe3)
  • transcription factor E3 (Tfe3)
  • bHLHe33 protein
  • F830016E06Rik protein
  • RCCP2 protein
  • RCCX1 protein
  • RGD1559642 protein
  • Tcfe3 protein
  • Tfe-3 protein
  • TFEA protein

Protein level used designations for Transcription Factor E3 Proteins (TFE3)

class E basic helix-loop-helix protein 33 , transcription factor E family, member A , transcription factor E3 , transcription factor for IgH enhancer , transcription factor for immunoglobulin heavy-chain enhancer 3

GENE ID SPECIES
7030 Homo sapiens
491872 Canis lupus familiaris
520800 Bos taurus
317376 Rattus norvegicus
495043 Xenopus laevis
209446 Mus musculus
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