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Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Additionally we are shipping Transcription Factor EB Antibodies (123) and many more products for this protein.
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The autophagic response to polystyrene nanoparticles is mediated by TFEB and depends on surface charge.
Review of the role of TFEB in lysosome biogenesis, transcriptional and post-transcriptional regulation of TFEB, and TFEB involvement in neurodegenerative disease as a dysregulated factor or as an agent used to promote cellular clearance.
TFEB and TFE3 (show TFE3 Proteins) are novel components of the integrated stress response
Silencing of TFEB with siRNAs in lung cancer cell lines resulted in reduced migration ability.
during mitophagy TFEB translocates to the nucleus and displays transcriptional activity in a PINK1 (show PINK1 Proteins)- and Parkin (show PARK2 Proteins)-dependent manner.
a virus modulating TFEB localization and helps to explain how HIV modulates autophagy to promote its own replication and cell survival
RIP1 (show UQCRFS1 Proteins) represses basal autophagy in part due to its ability to regulate the TFEB transcription factor;RIP1 (show UQCRFS1 Proteins) activates ERK (show EPHB2 Proteins), which negatively regulates TFEB though phosphorylation of serine 142
TFEB modulates autophagic clearance of alpha-syn
Data show that drug-induced TFEB-associated lysosomal biogenesis is a determinant of multidrug resistance (MDR) and suggest that circumvention of lysosomal drug sequestration is a strategy to overcome chemoresistance.
This study demonstrated that transcription factor EB (TFEB) regulate the lysosome biogenesis in neurons of APP (show APP Proteins)/PS1 (show PSEN1 Proteins) mice, steady-state levels of APP (show APP Proteins) were reduced, resulting in decreased interstitial fluid Abeta (show APP Proteins) levels and attenuated amyloid deposits
TFEB-regulated signaling pathway for osteoblast differentiation is involved in ATF4 (show ATF4 Proteins)/CHOP (show DDIT3 Proteins)-dependent signaling pathway.
TFEB participates in the Amyloid-beta-induced pathogenesis of Alzheimer's disease by regulating the autophagy-lysosome pathway in transgenic mice model of Alzheimer's disease.
Data indicate that transcription factor TFEB is a key participant in the differential regulation of the presentation of exogenous antigens by dendritic cells (DCs).
TFEB specifically targets hyperphosphorylated and misfolded Tau species present in both soluble and aggregated fractions while leaving normal Tau intact.
We examined the transcriptional regulation of autophagy and observed a functionally significant physical interaction between TFEB and AR in spinal and bulbar muscular atrophy (show AR Proteins).
TFEB was rapidly activated in murine macrophages upon S. aureus infection and was required for proper transcriptional induction of several proinflammatory cytokines and chemokines.
Overexpression of TFEB in a new muscle cell culture system and in mouse models of the disease reduced glycogen (show GYS1 Proteins) load and lysosomal size, improved autophagosome processing, and alleviated excessive accumulation of autophagic vacuoles.
findings show that TFEB, a master regulator of lysosomal biogenesis and autophagy, is induced by starvation through an autoregulatory feedback loop and exerts a global transcriptional control on lipid catabolism via Ppargc1alpha and Ppar1alpha
TFEB alone was capable of reducing htt (show HTT Proteins) aggregation and neurotoxicity, placing PGC-1alpha upstream of TFEB.
The zebrafish genome contain two mitf (mitfa (show MITF Proteins) and mitfb (show MITF Proteins)), two tfe3 (show TFE3 Proteins) (tfe3a and tfe3b), and single tfeb and tfec (show TFEC Proteins) genes.
Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T- cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta.
transcription factor EB
, transcription factor EB-like
, T-cell transcription factor EB
, class E basic helix-loop-helix protein 35