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Transducer of ERBB2, 2 Proteins (TOB2)

TOB2 belongs to the TOB (see TOB1\; MIM 605523)/BTG1 (MIM 109580) family of antiproliferative proteins, which are involved in the regulation of cell cycle progression.[supplied by OMIM, Apr 2004].. Additionally we are shipping Transducer of ERBB2, 2 Antibodies (32) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat TOB2 TOB2 315159  
TOB2 10766 Q14106
TOB2 57259 Q9JM55
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Top Transducer of ERBB2, 2 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 19 Days
$785.40
Details

TOB2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Transducer of ERBB2, 2 (TOB2) Interaction Partners

Human Transducer of ERBB2, 2 (TOB2) interaction partners

  1. Results show reduced Tob2 expression in primary hepatocellular Carcinoma cells (HCC (show FAM126A Proteins)) and that dysregulation of miR (show MLXIP Proteins)-362 and Tob2 may contribute to HCC (show FAM126A Proteins) malignancy.

  2. The antiproliferative and the mRNA deadenylation/decay-promoting effects of TOB1 and TOB2 proteins are linked.

  3. study identifies miR-378-TOB2-cyclin D1 as a functional module to mediate the cross talk between Myc and Ras signaling in cellular transformation

  4. TNFalpha (show TNF Proteins) is able to transactivate ErbB-2 (show ERBB2 Proteins) and use it as an obligatory downstream signaling molecule in the generation of mitogenic signals.

  5. Haploinsufficiency of the MLL (show MLL Proteins) and TOB2 genes in lymphoid malignancy.

  6. Antiproliferative proteins of the BTG/Tob (show TDO2 Proteins) family are degraded by the ubiquitin-proteasome system. the C-terminal regions are necessary and sufficient to control the stabilities of BTG1 (show BTG1 Proteins), BTG2 (show BTG2 Proteins), Tob (show TDO2 Proteins), and Tob2 proteins.

Mouse (Murine) Transducer of ERBB2, 2 (TOB2) interaction partners

  1. Tob1(-/-), Tob2(-/-), and Tob1/2 double knockout (DKO, Tob1(-/-) & Tob2(-/-)) embryonic stem cells (ESCs (show NR2E3 Proteins)) grew faster than wild type (WT) ESCs (show NR2E3 Proteins) without losing pluripotency.

  2. miR (show MLXIP Proteins)-322 and its target protein Tob2 modulate Osx (show SP7 Proteins) mRNA stability

  3. Tob2 protein suppresses PPARgamma2 (show PPARG Proteins) transcription by inhibiting BMP2 (show BMP2 Proteins)-induced Smad1 (show SMAD1 Proteins)/5 phosphorylation through its interaction with Smad6 (show SMAD6 Proteins) and by sequestering C/EBPalpha (show CEBPA Proteins) from the PPARgamma2 (show PPARG Proteins) promoter.

  4. Tob2 negatively regulates formation of osteoclasts by suppressing RANKL (show TNFSF11 Proteins) expression through its interaction with vitamin D receptor (show VDR Proteins)

Transducer of ERBB2, 2 (TOB2) Protein Profile

Protein Summary

TOB2 belongs to the TOB (see TOB1\; MIM 605523)/BTG1 (MIM 109580) family of antiproliferative proteins, which are involved in the regulation of cell cycle progression.

Gene names and symbols associated with Transducer of ERBB2, 2 Proteins (TOB2)

  • transducer of ERBB2, 2 (Tob2)
  • transducer of ERBB2, 2 (TOB2)
  • transducer of ERBB2, 2 (tob2)
  • 2900090N22Rik protein
  • 4930545K18Rik protein
  • AV071822 protein
  • mKIAA1663 protein
  • tob2 protein
  • TOB4 protein
  • TOBL protein
  • TROB2 protein

Protein level used designations for Transducer of ERBB2, 2 Proteins (TOB2)

protein Tob2 , transducer of ERBB2, 2 , protein Tob4 , transducer of erbB-2 2

GENE ID SPECIES
315159 Rattus norvegicus
458865 Pan troglodytes
548967 Xenopus (Silurana) tropicalis
707216 Macaca mulatta
10766 Homo sapiens
417992 Gallus gallus
481233 Canis lupus familiaris
507934 Bos taurus
57259 Mus musculus
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