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TBL2 encodes a member of the beta-transducin protein family. Additionally we are shipping Transducin (Beta)-Like 2 Antibodies (49) and many more products for this protein.
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TBL2 participates in ATF4 (show ATF4 Proteins) translation through its association with the mRNA.
association of TBL2 with the 60S subunit was ER stress independent while the TBL2-PERK interaction occurred upon ER stress
TBL2 interacts with PERK (show EIF2AK3 Proteins) via the N-terminus proximal region and also associates with eIF2a (show EIF2S1 Proteins) via the WD40 domain (show DCAF12L2 Proteins) thus modulating stress-signaling and cell survival during endoplasmic reticulum stress.
A TERE1 (show UBIAD1 Proteins)-TBL2 complex likely functions in oxidative/nitrosative stress, lipid metabolism, and SXR (show NR1I2 Proteins) signaling pathways in its role as a tumor suppressor.
Data show that SNPs associated with TG in normolipidemic samples, including APOA5 (show APOA5 Proteins), TRIB1 (show TRIB1 Proteins), TBL2, GCKR (show GCKR Proteins), GALNT2 (show GALNT2 Proteins) and ANGPTL3 (show ANGPTL3 Proteins) were significantly associated with HLP (show CYP3A4 Proteins) types 2B, 3, 4 and 5.
This gene encodes a member of the beta-transducin protein family. Most proteins of the beta-transducin family are involved in regulatory functions. This protein is possibly involved in some intracellular signaling pathway. This gene is deleted in Williams-Beuren syndrome, a developmental disorder caused by deletion of multiple genes at 7q11.23.
transducin (beta)-like 2
, transducin beta-like protein 2-like
, WS beta-transducin repeats protein
, Williams-Beuren syndrome chromosome region 13
, transducin beta-like protein 2