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TFRC encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. Additionally we are shipping Transferrin Receptor (p90, CD71) Antibodies (437) and Transferrin Receptor (p90, CD71) Kits (24) and many more products for this protein.
Showing 10 out of 27 products:
Human TFRC Protein expressed in Human Cells - ABIN2003733
Tosoni, Puri, Confalonieri, Salcini, De Camilli, Tacchetti, Di Fiore: TTP specifically regulates the internalization of the transferrin receptor. in Cell 2005
Show all 4 references for ABIN2003733
Mouse (Murine) TFRC Protein expressed in Human Cells - ABIN2008269
Douabin-Gicquel, Soriano, Ferran, Wojcik, Palierne, Tamim, Jovelin, McKie, Le Gall, David, Mosser: Identification of 96 single nucleotide polymorphisms in eight genes involved in iron metabolism: efficiency of bioinformatic extraction compared with a systematic sequencing approach. in Human genetics 2001
Show all 4 references for ABIN2008269
Cynomolgus TFRC Protein expressed in Human Cells - ABIN2010052
Wollscheid, Bausch-Fluck, Henderson, OBrien, Bibel, Schiess, Aebersold, Watts: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins. in Nature biotechnology 2009
Show all 3 references for ABIN2010052
Human TFRC Protein expressed in Escherichia coli (E. coli) - ABIN1047756
Schneider, Owen, Banville, Williams: Primary structure of human transferrin receptor deduced from the mRNA sequence. in Nature 1984
Show all 3 references for ABIN1047756
the value of transferrin receptors (TfRs)/cell reveals a 100-fold increase in the number of TfRs per bEnd3 cells compared to human umbilical vein cells.
our study reveals that TFR functions as a novel regulator to control AMPA (show GRIA3 Proteins) trafficking efficiency and synaptic plasticity
We found that iron assimilation via Tfr1 was critical for skeletal muscle metabolism, and that iron deficiency in muscle led to dramatic changes, not only in muscle, but also in adipose tissue and liver.
Mice lacking Tfr1 in the heart died in the second week of life and had cardiomegaly, poor cardiac function, failure of mitochondrial respiration, and ineffective mitophagy.
Transferrin Receptor 1 (show TFR Proteins) Facilitates Poliovirus Permeation of Mouse Brain Capillary Endothelial Cells.
Erythrocytic iron deficiency enhances susceptibility to Plasmodium chabaudi infection in mice carrying a missense mutation in tfr1.
Tfr1 has a role in homeostatic maintenance of the intestinal epithelium, acting through a role that is independent of its iron-uptake function
Analysis by qPCR showed changes in mRNA levels of iron-responsive genes, indicating moderately increased iron in the RPE (show RPE Proteins) of 10-month HID mice.
characterization of erythropoiesis, iron status, and hepcidin (show HAMP Proteins) expression in mice with global or hematopoietic cell-specific haploinsufficiency of transferrin receptor 1 (show TFR Proteins) provides initial supporting data for this model
high levels of TfRs such as those found on activated lymphocytes were found to be associated with decreased KLRG1 (show KLRG1 Proteins) inhibitory function, indicating that TfRs may sequester KLRG1 (show KLRG1 Proteins) from interacting with cadherins.
inverse correlation between the total percentage of CD71-positive NRBCs and gestational age suggests that this analysis may help in pregnancy dating
Data indicate an over-expression of transferrin receptor 1 (TFRC (show TFR Proteins)) in hepatocellular carcinoma (HCC (show FAM126A Proteins)) and a markedly decreased level of microRNA-152 (miR (show MLXIP Proteins)-152) when compared to non-tumor liver tissue.
Together, our findings reveal that TfR1 can contribute to the mitochondrial respiration and ROS (show ROS1 Proteins) production, which have essential roles in growth and survival of pancreatic cancer.
siRNA targeted delivery using transferrin (show Tf Proteins)-coupled lipoplexes specifically sensitizes CD71 high expressing malignant cells to antibody-mediated complement attack
The requirement for a threshold level of TFR1 expression can explain why among primary human hematopoietic cells, only erythroblasts efficiently take up H-ferritin.
Data indicate only the glycoproteins CD34 (show CD34 Proteins)+/CD71low population showed statistically significant differences between Diamond-Blackfan Anaemia (DBA (show RPS19 Proteins)) patients and controls.
These results demonstrate that in cells expressing the hTfR, Tacaribe virus internalization depends on the presence of cholesterol, dynamin (show DNM1 Proteins) and acidic intracellular vesicles.
The importance of TfR1 in adaptive immunity.A missense mutation in TFRC, encoding transferrin receptor 1 (show TFR Proteins), causes combined immunodeficiency.
The blood levels of TfRC was higher in age-related macular degeneration patients than controls.No association was found between age-related macular degeneration occurrence and the p.Gly142Ser polymorphism of the TRFC gene.
These data indicate that TfR1 expression in serum exosomes may provide a marker for regeneration in anaemic horses.
This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Mice that are deficient in this receptor show impaired erythroid development and abnormal iron homeostasis.
transferrin receptor protein 1
, transferrin receptor (p90, CD71)
, mammary tumor virus receptor 1