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This locus may represent a breast cancer candidate gene. Additionally we are shipping TACC1 Antibodies (49) and TACC1 Kits (1) and many more products for this protein.
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The correlation between TACC1 expression and HER-2 (show ERBB2 Proteins)-positive status indicates synergistic regulation of these two prognostic markers in gastric carcinoma patients.
TFF3 (show TFF3 Proteins) and TACC1 over-expression in epithelial cells of surgically resected gastric cancer tissues was an independent predictor of short survival in gastric cancer patients.
These findings provide proof and the foundation for the molecular and biological relationships of ErbB-2 (show ERBB2 Proteins) and TACC1 in breast cancer.
study reports that a small subset of glioblastoma multiforme tumors harbors oncogenic chromosomal translocations that fuse in-frame the tyrosine kinase (show TXK Proteins) coding domains of fibroblast growth factor receptor genes(FGFR1 (show FGFR1 Proteins) or FGFR3 (show FGFR3 Proteins)) to the transforming acidic coiled-coil coding domains of TACC1 or TACC3 (show TACC3 Proteins); the FGFR (show FGFR2 Proteins)-TACC fusion protein displays oncogenic activity
the study demonstrated that TACC1 localizes at the midbody during cytokinesis and interacts with and is a substrate of Aurora-C (show AURKC Proteins), which warrant further investigation in order to elucidate the functional significance of this interaction.
TACC1 depletion in the cell led to decreased RARalpha (show RARA Proteins) and TRalpha (show THRA Proteins) ligand-dependent transcriptional activity and to delocalization of TR from the nucleus to the cytoplasm.
Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells
Down regulation of tacc1 controls mrna homeostasis in polarized cells and participates in oncogenic processes in human cancers
TACC1 and the mitotic kinase Aurora B (show AURKB Proteins) belong to the same complex during cytokinesis.
TACC1 and a three-gene expression signature (TACC1, NOV (show NOV Proteins), and PTTG1 (show PTTG1 Proteins)) were identified as independent prognostic markers.
This locus may represent a breast cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers. Three transcript variants encoding different isoforms have been found for this gene.
transforming, acidic coiled-coil containing protein 1
, transforming acidic coiled-coil-containing protein 1-like
, gastric cancer antigen Ga55
, transforming acidic coiled-coil-containing protein 1
, transforming, acidic coiled-coil containing protein 1a