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Transforming, Acidic Coiled-Coil Containing Protein 3 Proteins (TACC3)

TACC3 encodes a member of the transforming acidic colied-coil protein family. Additionally we are shipping TACC3 Antibodies (60) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TACC3 21335  
TACC3 10460 Q9Y6A5
Rat TACC3 TACC3 360962  
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Top TACC3 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

TACC3 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,

More Proteins for Transforming, Acidic Coiled-Coil Containing Protein 3 (TACC3) Interaction Partners

Mouse (Murine) Transforming, Acidic Coiled-Coil Containing Protein 3 (TACC3) interaction partners

  1. Aurora-A kinase does not regulate TACC3-chTOG complex formation, indicating that Aurora-A solely functions as a recruitment factor for the TACC3-chTOG complex to centrosomes and proximal mitotic spindles.

  2. The TACC3 and clathrin were interdependent for spindle recruitment, having to interact in order for either to be recruited to the spindle.

  3. DOCK7 interaction with TACC3 controls interkinetic nuclear migration and the genesis of neurons from radial glial progenitor cells during cortical development

  4. results show that Tacc3 is a vulnerable component of the spindle assembly in lymphoma cells and is a promising cancer chemotherapy target

  5. Tacc3 is a negative regulator of the Notch (show NOTCH1 Proteins) signaling pathway.

  6. role in hematopoietic stem cell function and interface with p53 (show TP53 Proteins)-regulated apoptosis

  7. the alpha-helix of FOG (show APAF1 Proteins)-ZF3 recognizes a C-terminal portion of the TACC3 coiled-coil.

  8. in addition to spindle assembly, Tacc3 has critical roles in chromosome separation and cytokinesis, and is essential for the mitosis of sclerotome mesenchymal cells during axial formation in mammals.

Human Transforming, Acidic Coiled-Coil Containing Protein 3 (TACC3) interaction partners

  1. Results showed that high level of TACC3 expression was correlated with advanced clinicopathological classifications, and poor prognosis in non-small cell lung cancer patients indicating that TACC3 is a potential prognostic marker.

  2. TACC3 is enriched in hepatocellular carcinoma and down-regulation inhibits the proliferation, clonogenicity, and cancer stem cell-like phenotype of HCC (show FAM126A Proteins) cells

  3. The measurement of TACC3 protein expression may be beneficial for predicting clinical outcomes for gastric cancer patients

  4. TACC3 depletion in human cell lines causes shorter mitotic spindles. co-immunoprecipitation experiments showed reduced binding between TACC3-F543A and Aurora-A (show AURKA Proteins).

  5. TACC3 is expressed in esophageal squamous cell carcinoma and correlates with poor prognosis

  6. FGFR3 (show FGFR3 Proteins)-TACC3 rearrangements occur in a subset of patients with lung adenocarcinoma. Such patients should be considered for clinical trials featuring FGFR (show FGFR2 Proteins) inhibitors.

  7. our data demonstrated the oncogenic role of FGFR3 (show FGFR3 Proteins)-TACC3 in vitro, indicating that FGFR3 (show FGFR3 Proteins)-TACC3 may be useful as a diagnostic marker and therapeutic target in cancers.

  8. TACC3 depletion induces G1 arrest and cell death by activating p38 (show CRK Proteins)-p53 (show TP53 Proteins)-p21 (show CDKN1A Proteins) signaling and triggering a centrosome-mediated cellular stress response.

  9. findings suggest that TACC3 could be recruited as a bridge to cooperatively mediate between the HIF-2alpha (show EPAS1 Proteins) PAS (show PASK Proteins)-B.ARNT PAS (show PASK Proteins)-B complex, thereby participating more directly in HIF-dependent gene transcription than previously anticipated

  10. findings provide critical information regarding the mechanisms by which TACC3 contributes to genomic instability

Xenopus laevis Transforming, Acidic Coiled-Coil Containing Protein 3 (TACC3) interaction partners

  1. TACC1 (show TACC1 Proteins) and TACC3 are each required for maintaining normal microtubule growth speed in Xenopus

  2. XTACC3 can induce the recruitment of larger amounts of XMAP215 by increasing its local concentration, thereby promoting efficient microtubule elongation during mitosis

  3. TACC3 promotes axon outgrowth and regulates microtubule dynamics in multiple embryonic cell types.

  4. Results suggest that phosphorylation of maskin by Aurora-A (show AURKA Proteins) prevents meiosis II proteins from being produced during meiosis I.

  5. Maskin functions in mitotic spindle assembly.

  6. Maskin activity and localization is controlled by differential phosphorylation

  7. Maskin phosphorylation-dephosphorylation also oscillates with the cell cycle and is controlled by the kinase CDK1 (show CDK1 Proteins) and the phosphatase calcineurin (show PPP3CA Proteins)

  8. Maskin mRNA is translationally regulated by at least two repressor elements and an activation element.

TACC3 Protein Profile

Protein Summary

This gene encodes a member of the transforming acidic colied-coil protein family. The encoded protein is a motor spindle protein that may play a role in stabilization of the mitotic spindle. This protein may also play a role in growth a differentiation of certain cancer cells.

Gene names and symbols associated with TACC3

  • transforming, acidic coiled-coil containing protein 3 (Tacc3)
  • transforming, acidic coiled-coil containing protein 3 (TACC3)
  • transforming, acidic coiled-coil containing protein 3 (tacc3)
  • Aint protein
  • C86661 protein
  • ERIC-1 protein
  • ERIC1 protein
  • maskin protein
  • masking protein
  • xmaskin protein

Protein level used designations for TACC3

ARNT-interacting protein , Arnt interacting protein , transforming acidic coiled-coil-containing protein 3 , transforming acidic coiled coil 3 , CPEB-associated factor Maskin , cytoplasmic polyadenylation element-binding protein-associated factor Maskin

GENE ID SPECIES
21335 Mus musculus
10460 Homo sapiens
360962 Rattus norvegicus
398145 Xenopus laevis
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