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TACC3 encodes a member of the transforming acidic colied-coil protein family. Additionally we are shipping TACC3 Antibodies (50) and many more products for this protein.
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Aurora-A kinase does not regulate TACC3-chTOG complex formation, indicating that Aurora-A solely functions as a recruitment factor for the TACC3-chTOG complex to centrosomes and proximal mitotic spindles.
The TACC3 and clathrin were interdependent for spindle recruitment, having to interact in order for either to be recruited to the spindle.
DOCK7 interaction with TACC3 controls interkinetic nuclear migration and the genesis of neurons from radial glial progenitor cells during cortical development
results show that Tacc3 is a vulnerable component of the spindle assembly in lymphoma cells and is a promising cancer chemotherapy target
Tacc3 is a negative regulator of the Notch (show NOTCH1 Proteins) signaling pathway.
role in hematopoietic stem cell function and interface with p53 (show TP53 Proteins)-regulated apoptosis
the alpha-helix of FOG (show APAF1 Proteins)-ZF3 recognizes a C-terminal portion of the TACC3 coiled-coil.
in addition to spindle assembly, Tacc3 has critical roles in chromosome separation and cytokinesis, and is essential for the mitosis of sclerotome mesenchymal cells during axial formation in mammals.
TACC3 is enriched in hepatocellular carcinoma and down-regulation inhibits the proliferation, clonogenicity, and cancer stem cell-like phenotype of HCC (show FAM126A Proteins) cells
The measurement of TACC3 protein expression may be beneficial for predicting clinical outcomes for gastric cancer patients
TACC3 depletion in human cell lines causes shorter mitotic spindles. co-immunoprecipitation experiments showed reduced binding between TACC3-F543A and Aurora-A (show AURKA Proteins).
TACC3 is expressed in esophageal squamous cell carcinoma and correlates with poor prognosis
FGFR3 (show FGFR3 Proteins)-TACC3 rearrangements occur in a subset of patients with lung adenocarcinoma. Such patients should be considered for clinical trials featuring FGFR (show FGFR2 Proteins) inhibitors.
our data demonstrated the oncogenic role of FGFR3 (show FGFR3 Proteins)-TACC3 in vitro, indicating that FGFR3 (show FGFR3 Proteins)-TACC3 may be useful as a diagnostic marker and therapeutic target in cancers.
TACC3 depletion induces G1 arrest and cell death by activating p38 (show CRK Proteins)-p53 (show TP53 Proteins)-p21 (show CDKN1A Proteins) signaling and triggering a centrosome-mediated cellular stress response.
findings suggest that TACC3 could be recruited as a bridge to cooperatively mediate between the HIF-2alpha (show EPAS1 Proteins) PAS (show PASK Proteins)-B.ARNT PAS (show PASK Proteins)-B complex, thereby participating more directly in HIF-dependent gene transcription than previously anticipated
findings provide critical information regarding the mechanisms by which TACC3 contributes to genomic instability
TACC3 is involved in the regulation of microtubule nucleation at the centrosome and functions in the stabilization of the gamma-tubulin (show TUBG1 Proteins) ring complex assembly
TACC1 (show TACC1 Proteins) and TACC3 are each required for maintaining normal microtubule growth speed in Xenopus
XTACC3 can induce the recruitment of larger amounts of XMAP215 by increasing its local concentration, thereby promoting efficient microtubule elongation during mitosis
TACC3 promotes axon outgrowth and regulates microtubule dynamics in multiple embryonic cell types.
Results suggest that phosphorylation of maskin by Aurora-A (show AURKA Proteins) prevents meiosis II proteins from being produced during meiosis I.
Maskin functions in mitotic spindle assembly.
Maskin activity and localization is controlled by differential phosphorylation
Maskin phosphorylation-dephosphorylation also oscillates with the cell cycle and is controlled by the kinase CDK1 (show CDK1 Proteins) and the phosphatase calcineurin (show PPP3CA Proteins)
Maskin mRNA is translationally regulated by at least two repressor elements and an activation element.
This gene encodes a member of the transforming acidic colied-coil protein family. The encoded protein is a motor spindle protein that may play a role in stabilization of the mitotic spindle. This protein may also play a role in growth a differentiation of certain cancer cells.
, Arnt interacting protein
, transforming acidic coiled-coil-containing protein 3
, transforming acidic coiled coil 3
, CPEB-associated factor Maskin
, cytoplasmic polyadenylation element-binding protein-associated factor Maskin