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The protein encoded by TGFBR1 forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. Additionally we are shipping TGFBR1 Kits (18) and TGFBR1 Proteins (15) and many more products for this protein.
Showing 10 out of 134 products:
Human Polyclonal TGFBR1 Primary Antibody for EIA, IHC (p) - ABIN360163
Itoh, Thorikay, Kowanetz, Moustakas, Itoh, Heldin, ten Dijke: Elucidation of Smad requirement in transforming growth factor-beta type I receptor-induced responses. in The Journal of biological chemistry 2003
Show all 3 references for ABIN360163
Human Polyclonal TGFBR1 Primary Antibody for IF, ELISA - ABIN1450347
Franzén, ten Dijke, Ichijo, Yamashita, Schulz, Heldin, Miyazono: Cloning of a TGF beta type I receptor that forms a heteromeric complex with the TGF beta type II receptor. in Cell 1993
Show all 2 references for ABIN1450347
Human Polyclonal TGFBR1 Primary Antibody for FACS, IF (p) - ABIN671256
Xie, Chen, Miao, Tang, Fu: Regulation of cellular behaviors of fibroblasts related to wound healing by sol-gel derived bioactive glass particles. in Journal of biomedical materials research. Part A 2016
Show all 2 references for ABIN671256
Human Polyclonal TGFBR1 Primary Antibody for IF, ELISA - ABIN1532728
Vellucci, Reiss: Cloning and genomic organization of the human transforming growth factor-beta type I receptor gene. in Genomics 1998
Show all 2 references for ABIN1532728
Human Polyclonal TGFBR1 Primary Antibody for IHC (p), WB - ABIN392279
Miles, Tung, Aguiar, Kurtoglu, Sikes: Increased TGF-?1-mediated suppression of growth and motility in castrate-resistant prostate cancer cells is consistent with Smad2/3 signaling. in The Prostate 2012
Show all 2 references for ABIN392279
Human Polyclonal TGFBR1 Primary Antibody for ELISA, WB - ABIN563176
Matsunobu, Torigoe, Ishikawa, de Vega, Kulkarni, Iwamoto, Yamada: Critical roles of the TGF-beta type I receptor ALK5 in perichondrial formation and function, cartilage integrity, and osteoblast differentiation during growth plate development. in Developmental biology 2009
Human Polyclonal TGFBR1 Primary Antibody for IF, WB - ABIN317892
Yu, Hu, Yang, Takemori, Li, Zheng, Hong, Liao, Wen: Salt-inducible kinase 1 is involved in high glucose-induced mesangial cell proliferation mediated by the ALK5 signaling pathway. in International journal of molecular medicine 2013
Data show that signal transducing adaptor proteins APPL1 and APPL2 are required for TGFbeta-induced nuclear translocation of TGFbeta type I receptor (TbetaRI)-ICD and for cancer cell invasiveness of prostate and breast cancer cell lines.
Evidence supporting a genetic basis includes the autosomal dominance of Bicuspid aortic valve inheritance patterns, and the identification of mutations in transforming growth factor beta receptor 1.
This work details a novel mechanism by which cellular tension regulates TGFbeta (show TGFB1 Antibodies) receptor organization, multimerization, and function.
miR (show MLXIP Antibodies)-181b functions as a tumor suppressor and has an important role in proliferation, chemosensitivity to DDP (show TIMM8A Antibodies) and metastasis of NSCLC by targeting TGFbetaR1/Smad (show SMAD1 Antibodies) signaling pathway.
This paper highlights that targeting the BMP and TGFbeta (show TGFB1 Antibodies) type I and type II receptors causes a downregulation of XIAP (show XIAP Antibodies), TAK1 (show MAP3K7 Antibodies), and Id1 (show ID1 Antibodies) leading to cell death of lung cancer cells.
Protease activated receptor-1 (show F2R Antibodies) mediated dual kinase receptor transactivation stimulates the expression of glycosaminoglycan synthesizing genes and transforming growth factor beta receptor 1
Studies indicate that the transforming growth factor beta receptor I 6A (TbetaR-I 6A) allele was associated with breast cancer risk.
Women who carry the TGFBR1*6A allele are at lower risk of developing breast cancer.
the level of TGFBR1 and early osteogenic differentiation were abolished in the DPSCs transfected with siRNA for GnT-V knockdown...GnT-V plays a critical role in the hexosamine-induced activation of TGF-b signaling and osteogenic differentiation
Data suggest that transient suppression of TGFbeta (show TGFB1 Antibodies) receptor I (TGFbeta (show TGFB1 Antibodies) receptor) signaling may improve the outcome of islet transplantation.
The results indicate that the TGFBR1 gene polymorphism (SNP64) is significantly associated with growth rates including average daily gains between birth and 56 kg, between 5.5 and 56 kg, between 35 and 56 kg.
Report temporal regulation of TGFBR1 mRNA expression in the oocyte, granulosa and theca cells of developing preovulatory follicles in the pig.
TGFbeta (show TGFB1 Antibodies) is abundant in boar seminal plasma, thus TGFbeta (show TGFB1 Antibodies) may be a male-female signalling agent involved in immune changes in the female reproductive tract elicited by seminal fluid.
Porcine transforming growth factor beta receptor 1 has many polymorphisms, including two nonsynonymous substitutions in exons 1 and 7 and novel alternative splicing in exon 3.
isolation and molecular characterization; the full-length TGFBR1 cDNA 1813 bp contains an open reading frame (ORF) of 1512 bp encoding a TGFBR1 protein of 503 amino acids with a calculated molecular weight of 56.4 kDa.
Results show that ALK5 and ALK1 (show ACVRL1 Antibodies) play antagonistic roles in TGF-beta (show TGFB1 Antibodies)-induced podosome formation in aortic endothelial cells.
This study showed that ubiquitinated ALK5 and phosphorylated heat shock protein 27 specifically accumulate in the cytoskeleton fraction, and ALK1 (show ACVRL1 Antibodies) and ALK5 interact with heat shock protein 90 (show HSP90 Antibodies).
GM-CSF (show CSF2 Antibodies) induced airway smooth muscle cells to increase expression of transforming growth factor (TGF)-beta (show TGFB1 Antibodies) receptors type I, II, and III, but had no detectable effect on the release of TGF-beta1 (show TGFB1 Antibodies) by the same ASMC; corticosteroids were inhibitory
ALK5 and Smad4 (show SMAD4 Antibodies) have roles in TGF-beta1 (show TGFB1 Antibodies)-induced pulmonary endothelial permeability
These results indicate that high plasma cholesterol levels may contribute to the pathogenesis of certain diseases (e.g., atherosclerosis) by suppressing TGF-beta (show TGFB1 Antibodies) responsiveness.
Transforming growth factor-beta1 protects against pulmonary artery endothelial cell apoptosis via ALK5.
ALK1 and ALK5 are both essential for correct regulation of VEGF, and that disruption of either pathway leads to disease.
TGF-beta1 (show TGFB1 Antibodies) downregulates caveolin-1 (show CAV1 Antibodies) of cultured endothelial cells, involving ALK-5 receptor subtype
miR (show MLXIP Antibodies)-22 acts as a novel negative regulator of angiotensin II-induced cardiac fibrosis by suppressing the expression of TGFbetaRI in the heart.
TGFbetaRI inhibition in an injured adult heart could both stimulate the autocrine/paracrine activity of survivin (show BIRC5 Antibodies) and inhibit Wnt (show WNT2 Antibodies) in CPCs to mediate cardioprotection and improve cardiac function.
Data show that transforming growth factor-beta receptor I (Tgfbr1) was a direct target of microRNA miR (show MLXIP Antibodies)-140-5p.
Targeted early inactivation of Alk5 in mesodermal progenitors caused abnormal development and maturation of the lung that included reduced physical size of the sub-mesothelial mesoderm, an established source of specific mesodermal progenitors.
Beclin 1 (show BECN1 Antibodies) regulates neuronal transforming growth factor-beta signaling by mediating recycling of the type I receptor ALK5
TGFbeta (show TGFB1 Antibodies)-ALK5 signaling has an antifibrotic effect in experimental pulmonary fibrosis in mice, which is attenuated in the presence of concurrent gamma-herpesvirus infection
In vascular sprouting, neuropilin-1 (show NRP1 Antibodies) suppresses the stalk-cell phenotype by limiting Smad2 (show SMAD2 Antibodies)/3 activation through Alk1 (show ACVRL1 Antibodies) and Alk5. Notch (show NOTCH1 Antibodies) downregulates Nrp1 (show NRP1 Antibodies), thus relieving the inhibition of Alk1 (show ACVRL1 Antibodies) and Alk5, thereby driving stalk-cell behaviour.
Endocytic deficiency caused by ITSN (show ITSN1 Antibodies) knock-down modified Alk5 endocytic trafficking and enhances its degradation
Data indicate that absence of uterine activin receptor-like kinase 5 (ALK5) resulted in reduced female reproduction due to abnormalities observed at different stages of pregnancy.
Litomosoides sigmodontis induces TGF-beta (show TGFB1 Antibodies) receptor responsive, IL-10 (show IL10 Antibodies)-producing T cells that suppress bystander T-cell proliferation in mice.
The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene.
TGF-beta receptor type-1
, type I serine/threonine kinase receptor
, transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa)
, transforming growth factor beta type I receptor
, transforming growth factor, beta receptor 1 (activin A receptor type II-like kinase, 53kDa)
, transforming growth factor, beta receptor 1
, transforming growth factor beta receptor 1
, TGF-beta receptor type-1-like
, TGF-beta receptor type I
, TGF-beta type I receptor
, activin A receptor type II-like kinase, 53kD
, activin A receptor type II-like kinase, 53kDa
, activin A receptor type II-like protein kinase of 53kD
, activin receptor-like kinase 5
, serine/threonine-protein kinase receptor R4
, transforming growth factor beta receptor I
, transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kD)
, transforming growth factor-beta receptor type I
, transforming growth factor, beta receptor I
, activin A receptor type II-like kinase
, transforming growth factor beta receptor type I
, transforming growth factor beta, receptor 1