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Transforming Growth Factor, beta Receptor 1 Proteins (TGFBR1)

The protein encoded by TGFBR1 forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. Additionally we are shipping TGFBR1 Antibodies (127) and TGFBR1 Kits (18) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TGFBR1 7046 P36897
Rat TGFBR1 TGFBR1 29591  
TGFBR1 21812 Q64729
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Top TGFBR1 Proteins at antibodies-online.com

Showing 10 out of 15 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Baculovirus infected Insect Cells Human His tag,GST tag 50 μg Log in to see 16 Days
$338.80
Details
HOST_Human Cells Human His tag,Fc Tag 100 μg Log in to see 16 Days
$327.80
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$806.30
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,154.17
Details
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
$2,165.17
Details

TGFBR1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
, , , , ,
Mouse (Murine) , ,
, ,

Top referenced TGFBR1 Proteins

  1. Human TGFBR1 Protein expressed in Baculovirus infected Insect Cells - ABIN2002888 : Sridurongrit, Larsson, Schwartz, Ruiz-Lozano, Kaartinen: Signaling via the Tgf-beta type I receptor Alk5 in heart development. in Developmental biology 2008 (PubMed)

More Proteins for Transforming Growth Factor, beta Receptor 1 (TGFBR1) Interaction Partners

Human Transforming Growth Factor, beta Receptor 1 (TGFBR1) interaction partners

  1. Evidence supporting a genetic basis includes the autosomal dominance of Bicuspid aortic valve inheritance patterns, and the identification of mutations in transforming growth factor beta receptor 1.

  2. This work details a novel mechanism by which cellular tension regulates TGFbeta (show TGFB1 Proteins) receptor organization, multimerization, and function.

  3. miR (show MLXIP Proteins)-181b functions as a tumor suppressor and has an important role in proliferation, chemosensitivity to DDP (show TIMM8A Proteins) and metastasis of NSCLC by targeting TGFbetaR1/Smad (show SMAD1 Proteins) signaling pathway.

  4. This paper highlights that targeting the BMP and TGFbeta (show TGFB1 Proteins) type I and type II receptors causes a downregulation of XIAP (show XIAP Proteins), TAK1 (show MAP3K7 Proteins), and Id1 (show ID1 Proteins) leading to cell death of lung cancer cells.

  5. Protease activated receptor-1 (show F2R Proteins) mediated dual kinase receptor transactivation stimulates the expression of glycosaminoglycan synthesizing genes and transforming growth factor beta receptor 1

  6. Studies indicate that the transforming growth factor beta receptor I 6A (TbetaR-I 6A) allele was associated with breast cancer risk.

  7. Women who carry the TGFBR1*6A allele are at lower risk of developing breast cancer.

  8. the level of TGFBR1 and early osteogenic differentiation were abolished in the DPSCs transfected with siRNA for GnT-V knockdown...GnT-V plays a critical role in the hexosamine-induced activation of TGF-b signaling and osteogenic differentiation

  9. Data suggest that transient suppression of TGFbeta (show TGFB1 Proteins) receptor I (TGFbeta (show TGFB1 Proteins) receptor) signaling may improve the outcome of islet transplantation.

  10. Blocking TGFBR1 receptor up-regulated p21 (show CDKN1A Proteins) expression while inhibiting breast tumor cell growth.

Pig (Porcine) Transforming Growth Factor, beta Receptor 1 (TGFBR1) interaction partners

  1. The results indicate that the TGFBR1 gene polymorphism (SNP64) is significantly associated with growth rates including average daily gains between birth and 56 kg, between 5.5 and 56 kg, between 35 and 56 kg.

  2. Report temporal regulation of TGFBR1 mRNA expression in the oocyte, granulosa and theca cells of developing preovulatory follicles in the pig.

  3. TGFbeta (show TGFB1 Proteins) is abundant in boar seminal plasma, thus TGFbeta (show TGFB1 Proteins) may be a male-female signalling agent involved in immune changes in the female reproductive tract elicited by seminal fluid.

  4. Porcine transforming growth factor beta receptor 1 has many polymorphisms, including two nonsynonymous substitutions in exons 1 and 7 and novel alternative splicing in exon 3.

  5. isolation and molecular characterization; the full-length TGFBR1 cDNA 1813 bp contains an open reading frame (ORF) of 1512 bp encoding a TGFBR1 protein of 503 amino acids with a calculated molecular weight of 56.4 kDa.

Cow (Bovine) Transforming Growth Factor, beta Receptor 1 (TGFBR1) interaction partners

  1. Results show that ALK5 and ALK1 (show ACVRL1 Proteins) play antagonistic roles in TGF-beta (show TGFB1 Proteins)-induced podosome formation in aortic endothelial cells.

  2. This study showed that ubiquitinated ALK5 and phosphorylated heat shock protein 27 specifically accumulate in the cytoskeleton fraction, and ALK1 (show ACVRL1 Proteins) and ALK5 interact with heat shock protein 90 (show HSP90 Proteins).

  3. GM-CSF (show CSF2 Proteins) induced airway smooth muscle cells to increase expression of transforming growth factor (TGF)-beta (show TGFB1 Proteins) receptors type I, II, and III, but had no detectable effect on the release of TGF-beta1 (show TGFB1 Proteins) by the same ASMC; corticosteroids were inhibitory

  4. ALK5 and Smad4 (show SMAD4 Proteins) have roles in TGF-beta1 (show TGFB1 Proteins)-induced pulmonary endothelial permeability

  5. These results indicate that high plasma cholesterol levels may contribute to the pathogenesis of certain diseases (e.g., atherosclerosis) by suppressing TGF-beta (show TGFB1 Proteins) responsiveness.

  6. Transforming growth factor-beta1 protects against pulmonary artery endothelial cell apoptosis via ALK5.

  7. ALK1 and ALK5 are both essential for correct regulation of VEGF, and that disruption of either pathway leads to disease.

  8. TGF-beta1 (show TGFB1 Proteins) downregulates caveolin-1 (show CAV1 Proteins) of cultured endothelial cells, involving ALK-5 receptor subtype

Mouse (Murine) Transforming Growth Factor, beta Receptor 1 (TGFBR1) interaction partners

  1. Targeted early inactivation of Alk5 in mesodermal progenitors caused abnormal development and maturation of the lung that included reduced physical size of the sub-mesothelial mesoderm, an established source of specific mesodermal progenitors.

  2. Beclin 1 (show BECN1 Proteins) regulates neuronal transforming growth factor-beta signaling by mediating recycling of the type I receptor ALK5

  3. TGFbeta (show TGFB1 Proteins)-ALK5 signaling has an antifibrotic effect in experimental pulmonary fibrosis in mice, which is attenuated in the presence of concurrent gamma-herpesvirus infection

  4. In vascular sprouting, neuropilin-1 (show NRP1 Proteins) suppresses the stalk-cell phenotype by limiting Smad2 (show SMAD2 Proteins)/3 activation through Alk1 (show ACVRL1 Proteins) and Alk5. Notch (show NOTCH1 Proteins) downregulates Nrp1 (show NRP1 Proteins), thus relieving the inhibition of Alk1 (show ACVRL1 Proteins) and Alk5, thereby driving stalk-cell behaviour.

  5. Endocytic deficiency caused by ITSN knock-down modified Alk5 endocytic trafficking and enhances its degradation

  6. Data indicate that absence of uterine activin receptor-like kinase 5 (ALK5) resulted in reduced female reproduction due to abnormalities observed at different stages of pregnancy.

  7. Litomosoides sigmodontis induces TGF-beta (show TGFB1 Proteins) receptor responsive, IL-10 (show IL10 Proteins)-producing T cells that suppress bystander T-cell proliferation in mice.

  8. constitutive activation of TGFBR1 in the mouse uterus caused defects in uterine morphology and function, as evidenced by abnormal myometrial structure, dramatically reduced uterine glands, and impaired uterine decidualization.

  9. Inhibition of ALK5 improved intraislet endothelial cell numbers after islet culture, but this effect was lost in the early post-transplantation period.

  10. SD-208, a TbetaRI kinase inhibitor, stimulated tumour growth of invasive lobular carcinoma and bone metastases.

TGFBR1 Protein Profile

Protein Summary

The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with TGFBR1

  • transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa) (TGFBR1)
  • transforming growth factor, beta receptor 1 (tgfbr1)
  • transforming growth factor, beta receptor 1 (TGFBR1)
  • transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa) (LOC100230911)
  • transforming growth factor, beta receptor 1 (Tgfbr1)
  • transforming growth factor, beta receptor I (Tgfbr1)
  • AAT5 protein
  • ACVRLK4 protein
  • Alk-5 protein
  • Alk5 protein
  • AU017191 protein
  • LDS1A protein
  • LDS2A protein
  • MSSE protein
  • Skr4 protein
  • TbetaR-I protein
  • TbetaRI protein
  • TGFBR1 protein
  • Tgfr-1 protein
  • x-trr1 protein

Protein level used designations for TGFBR1

TGF-beta receptor type-1 , type I serine/threonine kinase receptor , transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa) , transforming growth factor beta type I receptor , transforming growth factor, beta receptor 1 (activin A receptor type II-like kinase, 53kDa) , transforming growth factor, beta receptor 1 , transforming growth factor beta receptor 1 , TGF-beta receptor type-1-like , TGF-beta receptor type I , TGF-beta type I receptor , activin A receptor type II-like kinase, 53kD , activin A receptor type II-like kinase, 53kDa , activin A receptor type II-like protein kinase of 53kD , activin receptor-like kinase 5 , serine/threonine-protein kinase receptor R4 , tbetaR-I , transforming growth factor beta receptor I , transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kD) , transforming growth factor-beta receptor type I , transforming growth factor, beta receptor I , TGFR-1 , activin A receptor type II-like kinase , transforming growth factor beta receptor type I , transforming growth factor beta, receptor 1 , ESK2

GENE ID SPECIES
374094 Gallus gallus
399295 Xenopus laevis
403428 Canis lupus familiaris
472992 Pan troglodytes
481628 Canis lupus familiaris
548715 Xenopus (Silurana) tropicalis
554326 Ovis aries
714952 Macaca mulatta
100230911 Taeniopygia guttata
100389596 Callithrix jacchus
100450864 Pongo abelii
100592854 Nomascus leucogenys
7046 Homo sapiens
29591 Rattus norvegicus
396665 Sus scrofa
282382 Bos taurus
21812 Mus musculus
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