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Transforming Growth Factor, beta Receptor II (70/80kDa) Proteins (TGFBR2)

TGFBR2 encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. Additionally we are shipping TGFBR2 Antibodies (113) and TGFBR2 Kits (17) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TGFBR2 21813 Q62312
TGFBR2 81810 P38438
TGFBR2 7048 P37173
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Top TGFBR2 Proteins at antibodies-online.com

Showing 10 out of 26 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Human Fc Tag 100 μg Log in to see 2 to 3 Days
$346.50
Details
HOST_Human Cells Human His tag,Fc Tag 50 μg Log in to see 16 Days
$382.80
Details
HOST_Human Cells Cynomolgus Fc Tag 50 μg Log in to see 16 Days
$382.80
Details
HOST_Human Cells Rat Fc Tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_HEK-293 Human Fc Tag   0.1 mg Log in to see 2 to 3 Days
$618.75
Details

TGFBR2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) , , ,
, , ,
Rat (Rattus) ,
,
Human , , , , , , ,
, , , ,

Top referenced TGFBR2 Proteins

  1. Human TGFBR2 Protein expressed in Human Cells - ABIN2002668 : Lin, Wang, Ng-Eaton, Weinberg, Lodish: Expression cloning of the TGF-beta type II receptor, a functional transmembrane serine/threonine kinase. in Cell 1992 (PubMed)
    Show all 6 references for ABIN2002668

  2. Human TGFBR2 Protein expressed in HEK-293 Cells - ABIN2181811 : Deep, Walker, Shu, Hinck: Solution structure and backbone dynamics of the TGFbeta type II receptor extracellular domain. in Biochemistry 2003 (PubMed)
    Show all 3 references for ABIN2181811

  3. Rat (Rattus) TGFBR2 Protein expressed in Human Cells - ABIN2009206 : Ghatpande, Zhou, Cakstina, Carlson, Rondini, Romeih, Zile: Transforming growth factor beta2 is negatively regulated by endogenous retinoic acid during early heart morphogenesis. in Development, growth & differentiation 2010 (PubMed)
    Show all 2 references for ABIN2009206

  4. Cynomolgus TGFBR2 Protein expressed in Human Cells - ABIN2009791 : Schlingensiepen, Schlingensiepen, Steinbrecher, Hau, Bogdahn, Fischer-Blass, Jachimczak: Targeted tumor therapy with the TGF-beta 2 antisense compound AP 12009. in Cytokine & growth factor reviews 2006 (PubMed)
    Show all 2 references for ABIN2009791

More Proteins for Transforming Growth Factor, beta Receptor II (70/80kDa) (TGFBR2) Interaction Partners

Rhesus Monkey Transforming Growth Factor, beta Receptor II (70/80kDa) (TGFBR2) interaction partners

  1. Expression of microRNA miR (show MYLIP Proteins)-155 was significantly upregulated in the oropharyngeal mucosa during chronic SIV infection and was coincident with downregulation of TGFbeta (show TGFB1 Proteins) receptor 2 (TGFbeta (show TGFB1 Proteins)-R2) and SMAD5 (show SMAD5 Proteins).

Mouse (Murine) Transforming Growth Factor, beta Receptor II (70/80kDa) (TGFBR2) interaction partners

  1. Epithelial TGFbeta (show TGFB1 Proteins) signaling via TGFBR2 does not contribute to the development of liver fibrosis or formation of hepatocellular carcinomas in mice, but restricts cholangiocyte proliferation to prevent cholangiocarcinoma development.

  2. The removal of Tgfbr2 and treatment with losartan both delayed the progression of articular cartilage degeneration induced by medial meniscus (DMM (show COL2A1 Proteins)) compared with control littermates.

  3. Data (including data from studies in transgenic mice) suggest intraislet pancreatic duct cells are capable of giving rise to insulin (show INS Proteins)-secreting beta-cells; Tgfbr2/transforming growth factor-beta type II receptor appears to be involved in this process.

  4. Elimination of TGF-betaIIR is not sufficient to completely prevent liver fibrosis. TGF-beta (show TGFB1 Proteins)-independent mechanism of type I collagen production and suggest connective tissue growth factor (show CTGF Proteins) as its potent mediator.

  5. Overexpression of TGFbeta1 (show TGFB1 Proteins) promotes pulmonary inflammation, apoptosis and mortality via TGFbetaR2 in the developing mouse lung.

  6. Loss of smooth muscle cells Tgfbr2 disrupts TGF-beta (show TGFB1 Proteins) signaling, acutely alters SMC (show DYM Proteins) gene expression, and rapidly results in severe and durable aortopathy.

  7. Increased Tgfbr2 expression is associated with pulmonary fibrosis.

  8. High TGFBR2 expression is associated with pancreatic carcinoma.

  9. Suggest that miR (show MLXIP Proteins)-370 acting via TbetaRII might play a potential role in hepatic IR injury, and inhibition of miR (show MLXIP Proteins)-370 efficiently attenuated the damage to the liver.

  10. skeletal phenotype of mice carrying a mutation in the TGF-beta (show TGFB1 Proteins) type 2 receptor associated with severe Loeys-Dietz syndrome in humans: Cortical bone showed significantly reduced tissue area, bone area, and cortical thickness with increased eccentricity

Human Transforming Growth Factor, beta Receptor II (70/80kDa) (TGFBR2) interaction partners

  1. Reduced expression of TGF-beta type II receptor and extracellular matrix components in response to reduced fibroblast size/mechanical force was fully reversed by restoring size/mechanical force

  2. results suggested that high CDKN1A/p21 (show CDKN1A Proteins) and low TGFBR2 expression was closely correlated with adverse pathological parameters and poor prognosis in breast cancer.

  3. This work details a novel mechanism by which cellular tension regulates TGFbeta (show TGFB1 Proteins) receptor organization, multimerization, and function.

  4. Findings suggest that the upregulation of miR (show MLXIP Proteins)-590-5p promotes cellular malignant behavior via the target gene TGFbetaRII in vulvar squamous cell carcinoma.

  5. This paper highlights that targeting the BMP and TGFbeta (show TGFB1 Proteins) type I and type II receptors causes a downregulation of XIAP (show XIAP Proteins), TAK1 (show MAP3K7 Proteins), and Id1 (show ID1 Proteins) leading to cell death of lung cancer cells.

  6. TGF-beta2 (show TGFB2 Proteins) induces Grb2 (show GRB2 Proteins) to recruit PI3-K (show PIK3CA Proteins) to TGF-RII that activates JNK (show MAPK8 Proteins)/AP-1 (show FOSB Proteins)-signaling and augments invasiveness of Theileria-transformed macrophages.

  7. TGFBR2 is regulated by an epigenetic auto-feedback regulation in non-small cell lung cancer.

  8. we reported a sporadic Japanese case of LDS with a novel TGFBR2 p.Y424H mutation, which appeared to cause pregnancy-related fatal aortic/arterial dissections.

  9. AT2R (show AGTR2 Proteins) downregulates the expression of TGF-betaRII in human proximal tubule cells

  10. Case Report: endovascular repair of a left vertebral artery aneurysm in a patient with transforming growth factor beta receptor II mutation.

Cow (Bovine) Transforming Growth Factor, beta Receptor II (70/80kDa) (TGFBR2) interaction partners

  1. These results indicate that high plasma cholesterol levels may contribute to the pathogenesis of certain diseases (e.g., atherosclerosis) by suppressing TGF-beta (show TGFB1 Proteins) responsiveness.

TGFBR2 Protein Profile

Protein Summary

This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized.

Gene names and symbols associated with TGFBR2

  • transforming growth factor, beta receptor II (70/80kDa) (TGFBR2)
  • transforming growth factor, beta receptor II (TGFBR2)
  • transforming growth factor, beta receptor II (70/80kDa) (LOC100220619)
  • transforming growth factor beta receptor II (LOC100038019)
  • transforming growth factor, beta receptor II (Tgfbr2)
  • transforming growth factor, beta receptor II-like (LOC424261)
  • 1110020H15Rik protein
  • AAT3 protein
  • AU042018 protein
  • DNIIR protein
  • FAA3 protein
  • LDS1B protein
  • LDS2B protein
  • MFS2 protein
  • RIIC protein
  • RIIDN protein
  • TAAD2 protein
  • TBETA-RII protein
  • TbetaR-II protein
  • TbetaRII protein
  • TBR-II protein
  • TGF-beta 2 protein
  • TGFbeta-RII protein
  • TGFBR2 protein
  • Tgfbr2T protein
  • TGFBRII protein
  • TGFR-2 protein

Protein level used designations for TGFBR2

transforming growth factor, beta receptor II (70/80kDa) , transforming growth factor beta type II receptor , transforming growth factor, beta receptor II , transforming growth factor beta receptor 2 , TGF-beta receptor type-2 , TGF beta receptor type II , TGF-beta receptor type-2-like , TGF-beta receptor II , TGF-beta receptor type II , TGF-beta type II receptor , TGFR-2 , transforming growth factor-beta receptor type II , tbetaR-II , transforming growth factor beta receptor type II , transforming growth factor beta, receptor 2 , transforming growth factor, beta receptor 2 , transforming growth factor, beta receptor IIT , transforming growth factor-b type II receptor , transforming growth factor-beta type II receptor , TGF-beta receptor type IIB , transforming growth factor beta receptor type IIC

GENE ID SPECIES
460243 Pan troglodytes
477039 Canis lupus familiaris
494191 Ovis aries
703088 Macaca mulatta
100031897 Monodelphis domestica
100033860 Equus caballus
100076965 Ornithorhynchus anatinus
100404359 Callithrix jacchus
100459236 Pongo abelii
100482939 Ailuropoda melanoleuca
100220619 Taeniopygia guttata
100606849 Nomascus leucogenys
100038019 Sus scrofa
21813 Mus musculus
81810 Rattus norvegicus
396399 Gallus gallus
7048 Homo sapiens
535376 Bos taurus
424261 Gallus gallus
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