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TGFBR2 encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. Additionally we are shipping TGFBR2 Kits (38) and TGFBR2 Proteins (33) and many more products for this protein.
Showing 10 out of 213 products:
Mouse (Murine) Polyclonal TGFBR2 Primary Antibody for FACS - ABIN4898045
Lewis, Macal, Hesser, Zuñiga et al.: Constitutive but not inducible attenuation of transforming growth factor β signaling increases natural killer cell responses without directly affecting dendritic cells early after persistent viral ... in Journal of virology 2015
Show all 6 references for 4898045
Human Polyclonal TGFBR2 Primary Antibody for IF (p), IHC (p) - ABIN725225
Abdelmagid, Belcher, Moussa, Lababidi, Sondag, Novak, Sanyurah, Frara, Razmpour, Del Carpio-Cano, Safadi: Mutation in osteoactivin decreases bone formation in vivo and osteoblast differentiation in vitro. in The American journal of pathology 2014
Show all 3 references for 725225
Mouse (Murine) Polyclonal TGFBR2 Primary Antibody for FACS - ABIN4898041
Bodogai, Moritoh, Lee-Chang, Hollander, Sherman-Baust, Wersto, Araki, Miyoshi, Yang, Trinchieri, Biragyn: Immunosuppressive and Prometastatic Functions of Myeloid-Derived Suppressive Cells Rely upon Education from Tumor-Associated B Cells. in Cancer research 2015
Human Monoclonal TGFBR2 Primary Antibody for FACS - ABIN4898035
Lages, Suffia, Velilla, Huang, Warshaw, Hildeman, Belkaid, Chougnet: Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation. in Journal of immunology (Baltimore, Md. : 1950) 2008
Human Polyclonal TGFBR2 Primary Antibody for FACS - ABIN4898025
Rani, Smulian, Greaves, Hogan, Herbert: TGF-β limits IL-33 production and promotes the resolution of colitis through regulation of macrophage function. in European journal of immunology 2011
Human Monoclonal TGFBR2 Primary Antibody for FACS - ABIN4898031
Hermitte, Brunet de la Grange, Belloc, Praloran, Ivanovic: Very low O2 concentration (0.1%) favors G0 return of dividing CD34+ cells. in Stem cells (Dayton, Ohio) 2006
Mouse (Murine) Polyclonal TGFBR2 Primary Antibody for IF, IHC (p) - ABIN655799
Liang, Li, Zhang, Cui, Quan, Yang: The anti-fibrotic effects of microRNA-153 by targeting TGFBR-2 in pulmonary fibrosis. in Experimental and molecular pathology 2015
Cow (Bovine) Polyclonal TGFBR2 Primary Antibody for WB - ABIN2781999
Song, Krebs, Danielpour: Novel permissive role of epidermal growth factor in transforming growth factor beta (TGF-beta) signaling and growth suppression. Mediation by stabilization of TGF-beta receptor type II. in The Journal of biological chemistry 2006
Expression of microRNA miR (show MYLIP Antibodies)-155 was significantly upregulated in the oropharyngeal mucosa during chronic SIV infection and was coincident with downregulation of TGFbeta (show TGFB1 Antibodies) receptor 2 (TGFbeta (show TGFB1 Antibodies)-R2) and SMAD5 (show SMAD5 Antibodies).
Cell-intrinsic TGFbeta-RII signaling limits CD4 (show CD4 Antibodies) T cell proliferation but not prototypical T helper subset differentiation early after chronic lymphocytic choriomeningitis virus infection.
These results suggest that DMSO, a fusogenic substance, enhances TGF-beta (show TGFB1 Antibodies) activity presumably by inducing fusion of cytoplasmic vesicles (containing TbetaR-II) and the plasma membrane, resulting in increased localization of TbetaR-II to non-lipid raft microdomains where canonical signaling occurs.
USP11 (show USP11 Antibodies) may contribute to the pathogenesis of pulmonary fibrosis by stabilization of TbetaRII and promotion of TGFbeta (show TGFB1 Antibodies)-1 signaling.
both GDF-15 (show GDF15 Antibodies) and TGF-beta1 (show TGFB1 Antibodies) counteract chemokine (show CCL1 Antibodies)-induced integrin activation on neutrophils via the ALK-5 (show TGFBR1 Antibodies)/TGF-betaRII heterodimer.
Knockout of the TGFbeta (show TGFB1 Antibodies) receptor in proopiomelanocortin (show POMC Antibodies) neurons counteracts the hypertensive effect of not only TGFbeta (show TGFB1 Antibodies) but also mtDNA excess, while the hypertensive action of central mtDNA can be blocked pharmacologically by a TGFbeta (show TGFB1 Antibodies) receptor antagonist or genetically by TGFbeta (show TGFB1 Antibodies) receptor knockout.
Postnatal disruption of Tgfbr2 gene compromises extracellular matrix properties and promotes aortic dissection, which can be prevented by rapamycin treatment.
Gasdermin C is upregulated by inactivation of Tgfbr2 in the presence of mutated Apc (show APC Antibodies), promoting colorectal cancer cell proliferation.
In the presence of gadolinium and antibeta1 integrin antibody, collagen regulated the expression levels of Tgfbr1 (show TGFBR1 Antibodies), Tgfbr2 and Smad2 (show SMAD2 Antibodies)/3, but did not alter the phosphorylation of p38 (show CRK Antibodies), ERK1/2 (show MAPK1/3 Antibodies) or JNK (show MAPK8 Antibodies).
Epithelial TGFbeta (show TGFB1 Antibodies) signaling via TGFBR2 does not contribute to the development of liver fibrosis or formation of hepatocellular carcinomas in mice, but restricts cholangiocyte proliferation to prevent cholangiocarcinoma development.
The removal of Tgfbr2 and treatment with losartan both delayed the progression of articular cartilage degeneration induced by medial meniscus (DMM (show COL2A1 Antibodies)) compared with control littermates.
TGF-beta (show TGFB1 Antibodies) type I, II, and III receptors were all identified in pregnant serum; all were substantially elevated in early-onset but not late-onset PE. Endoglin (show ENG Antibodies) was increased in both subtypes.
Although TGFbeta1 (show TGFB1 Antibodies)/2 receptors are downregulated in breast cancer, their expression in tumors is an indicator of aggressive breast cancer phenotype.
this is the first clinical report to demonstrate a potential causal association between TGFB2 (show TGFB2 Antibodies) gene mutations and aortic root dilatation in combination with the myxomatous degeneration of both atrioventricular valves.
Molecular modeling and molecular dynamic simulation of the effects of variants in the TGFBR2 kinase domain as a paradigm for interpretation of variants obtained by next generation sequencing.
A novel mutation in the TGFBR2 gene was identified in a patient with Loeys-Dietz syndrome.
ZNF32 (show ADRA2A Antibodies) was found to directly bind to the TGF-betaR2 (transforming growth factor-beta receptor 2) promoter to promote its expression.
High TGFBR2 expression is associated with glioma.
these findings delineate the important function of the TGFbeta (show TGFB1 Antibodies) signaling pathway in the early development of kidney and TbetaRII was shown to be able to promote the expression of Six2 (show SIX2 Antibodies) through Smad3 (show SMAD3 Antibodies) mediating transcriptional regulation and in turn activate the proliferation of MM cells.
YAP-1 (show YAP1 Antibodies) promotes Tregs differentiation in hepatocellular carcinoma by enhancing TGFBR2 transcription.
These results indicate that high plasma cholesterol levels may contribute to the pathogenesis of certain diseases (e.g., atherosclerosis) by suppressing TGF-beta (show TGFB1 Antibodies) responsiveness.
This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized.
transforming growth factor, beta receptor II (70/80kDa)
, transforming growth factor beta type II receptor
, transforming growth factor, beta receptor II
, transforming growth factor beta receptor 2
, TGF-beta receptor type-2
, TGF beta receptor type II
, TGF-beta receptor type-2-like
, TGF-beta receptor II
, TGF-beta receptor type II
, TGF-beta type II receptor
, transforming growth factor-beta receptor type II
, transforming growth factor beta receptor type II
, transforming growth factor beta, receptor 2
, transforming growth factor, beta receptor 2
, transforming growth factor, beta receptor IIT
, transforming growth factor-b type II receptor
, transforming growth factor-beta type II receptor
, TGF-beta receptor type IIB
, transforming growth factor beta receptor type IIC