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Transforming Growth Factor, beta Receptor II (70/80kDa) Proteins (TGFBR2)

TGFBR2 encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. Additionally we are shipping TGFBR2 Antibodies (166) and TGFBR2 Kits (23) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TGFBR2 21813 Q62312
TGFBR2 81810 P38438
TGFBR2 7048 P37173
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Top TGFBR2 Proteins at antibodies-online.com

Showing 10 out of 28 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human Fc Tag,His tag 50 μg Log in to see 20 to 21 Days
$382.80
Details
HOST_HEK-293 Cells Human Fc Tag Human TGF-beta RII, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. 100 μg Log in to see 2 to 3 Days
$346.50
Details
HOST_Human Cells Rhesus Monkey Fc Tag 50 μg Log in to see 20 to 21 Days
$382.80
Details
HOST_Human Cells Rat Fc Tag 100 μg Log in to see 20 to 21 Days
$382.80
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 Days
$5,442.50
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Mammalian Cells Human Fc Tag   50 μg Log in to see 5 Days
$385.00
Details
HOST_Human Human Fc Tag   10 μg Log in to see 11 Days
$225.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Mammalian Cells Mouse Fc Tag   50 μg Log in to see 5 Days
$248.33
Details

TGFBR2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) , ,
, , ,
Rat (Rattus) ,
,
Human , , , , , , , ,
, , , ,

Top referenced TGFBR2 Proteins

  1. Human TGFBR2 Primary Antibody for - ABIN2002668 : Lin, Wang, Ng-Eaton, Weinberg, Lodish: Expression cloning of the TGF-beta type II receptor, a functional transmembrane serine/threonine kinase. in Cell 1992 (PubMed)
    Show all 6 references for ABIN2002668

  2. Human TGFBR2 Primary Antibody for - ABIN2181811 : Deep, Walker, Shu, Hinck: Solution structure and backbone dynamics of the TGFbeta type II receptor extracellular domain. in Biochemistry 2003 (PubMed)
    Show all 3 references for ABIN2181811

  3. Rat (Rattus) TGFBR2 Primary Antibody for - ABIN2009206 : Ghatpande, Zhou, Cakstina, Carlson, Rondini, Romeih, Zile: Transforming growth factor beta2 is negatively regulated by endogenous retinoic acid during early heart morphogenesis. in Development, growth & differentiation 2010 (PubMed)
    Show all 2 references for ABIN2009206

  4. Cynomolgus TGFBR2 Primary Antibody for - ABIN2009791 : Schlingensiepen, Schlingensiepen, Steinbrecher, Hau, Bogdahn, Fischer-Blass, Jachimczak: Targeted tumor therapy with the TGF-beta 2 antisense compound AP 12009. in Cytokine & growth factor reviews 2006 (PubMed)
    Show all 2 references for ABIN2009791

More Proteins for Transforming Growth Factor, beta Receptor II (70/80kDa) (TGFBR2) Interaction Partners

Rhesus Monkey Transforming Growth Factor, beta Receptor II (70/80kDa) (TGFBR2) interaction partners

  1. Expression of microRNA miR (show MYLIP Proteins)-155 was significantly upregulated in the oropharyngeal mucosa during chronic SIV infection and was coincident with downregulation of TGFbeta (show TGFB1 Proteins) receptor 2 (TGFbeta (show TGFB1 Proteins)-R2) and SMAD5 (show SMAD5 Proteins).

Mouse (Murine) Transforming Growth Factor, beta Receptor II (70/80kDa) (TGFBR2) interaction partners

  1. In the presence of gadolinium and antibeta1 integrin antibody, collagen regulated the expression levels of Tgfbr1 (show TGFBR1 Proteins), Tgfbr2 and Smad2 (show SMAD2 Proteins)/3, but did not alter the phosphorylation of p38 (show CRK Proteins), ERK1/2 or JNK (show MAPK8 Proteins).

  2. Epithelial TGFbeta (show TGFB1 Proteins) signaling via TGFBR2 does not contribute to the development of liver fibrosis or formation of hepatocellular carcinomas in mice, but restricts cholangiocyte proliferation to prevent cholangiocarcinoma development.

  3. The removal of Tgfbr2 and treatment with losartan both delayed the progression of articular cartilage degeneration induced by medial meniscus (DMM (show COL2A1 Proteins)) compared with control littermates.

  4. Data (including data from studies in transgenic mice) suggest intraislet pancreatic duct cells are capable of giving rise to insulin (show INS Proteins)-secreting beta-cells; Tgfbr2/transforming growth factor-beta type II receptor appears to be involved in this process.

  5. Elimination of TGF-betaIIR is not sufficient to completely prevent liver fibrosis. TGF-beta (show TGFB1 Proteins)-independent mechanism of type I collagen production and suggest connective tissue growth factor (show CTGF Proteins) as its potent mediator.

  6. Overexpression of TGFbeta1 (show TGFB1 Proteins) promotes pulmonary inflammation, apoptosis and mortality via TGFbetaR2 in the developing mouse lung.

  7. Loss of smooth muscle cells Tgfbr2 disrupts TGF-beta (show TGFB1 Proteins) signaling, acutely alters SMC (show DYM Proteins) gene expression, and rapidly results in severe and durable aortopathy.

  8. Increased Tgfbr2 expression is associated with pulmonary fibrosis.

  9. High TGFBR2 expression is associated with pancreatic carcinoma.

  10. Suggest that miR (show MLXIP Proteins)-370 acting via TbetaRII might play a potential role in hepatic IR injury, and inhibition of miR (show MLXIP Proteins)-370 efficiently attenuated the damage to the liver.

Human Transforming Growth Factor, beta Receptor II (70/80kDa) (TGFBR2) interaction partners

  1. Study demonstrated that the TGFBR2 mutation was not present in the sample of cervico-cerebral artery dissection patients (CCAD); however, a positive association was identified between the MTHFR (show MTHFR Proteins)-C677T polymorphism and genetically confirmed Mexican mestizo spontaneous CCAD patients

  2. The results showed that transfection of CD34 (show CD34 Proteins)(+) cells with SiRNA targeting TGF-bRII and their co-culture with human bone marrow mesenchymal stromal cells (MSCs) could considerably increase the number of progenitors

  3. Cell invasion (matrigel) was reduced only in the Hs578T cells (p < 0.01). Silencing decreased the expression of the prometastatic molecules S100A4 (show S100A4 Proteins) and TGFbetaR2 in both cell lines and CD44 (show CD44 Proteins) in Hs578T cells. We conclude that ECM1 (show ECM1 Proteins) is a key player in the metastatic process and regulates the actin cytoskeletal architecture of aggressive breast cancer cells at least in part via alterations in S100A4 (show S100A4 Proteins) and Rho A (show RHOA Proteins).

  4. Our study uncovers a novel mechanism that miR (show MLXIP Proteins)-19a-3p/19b-3p inhibits autophagy-mediated fibrogenesis by targeting TGF-beta (show TGFB1 Proteins) R II.

  5. TGFBR2 signaling can affect Notch1 (show NOTCH1 Proteins) glycosylation via regulation of glycosyltransferase (show GTDC2 Proteins) LFNG (show LFNG Proteins) expression and provide a first mechanistic example for altered glycosylation in microsatellite instability colorectal tumor cells.

  6. CD44 (show CD44 Proteins) and TGFBR2 are the functional targets of miR (show MLXIP Proteins)-373, which are responsible for the tumor suppressive functions of miR (show MLXIP Proteins)-373

  7. Polymorphism of TGFBR2 is associated with coronary artery disease.

  8. Exogenous expression of miR (show MLXIP Proteins)-142-5p inhibitor resulted in a significant reduction of viral titer indicating proviral role of miR (show MLXIP Proteins)-142-5p. Functional studies of hsa (show CD24 Proteins)-miR (show MLXIP Proteins)-142-5p identified its role in transforming growth factor beta (TGFbeta (show TGFB1 Proteins)) signalling as TGFbeta (show TGFB1 Proteins) receptor 2 and SMAD3 (show SMAD3 Proteins) were degraded during both hsa (show CD24 Proteins)-miR (show MLXIP Proteins)-142-5p overexpression and rotavirus infection.

  9. Results found TGFBR2 to be significantly related to the regulated phosphoproteome in glioblastoma as a result of integrative upstream kinase/ regulator analyses and experimentally validated as a novel regulator of glioblastoma stem cells.

  10. Reduced expression of TGF-beta type II receptor and extracellular matrix components in response to reduced fibroblast size/mechanical force was fully reversed by restoring size/mechanical force

Cow (Bovine) Transforming Growth Factor, beta Receptor II (70/80kDa) (TGFBR2) interaction partners

  1. These results indicate that high plasma cholesterol levels may contribute to the pathogenesis of certain diseases (e.g., atherosclerosis) by suppressing TGF-beta (show TGFB1 Proteins) responsiveness.

TGFBR2 Protein Profile

Protein Summary

This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized.

Gene names and symbols associated with TGFBR2

  • transforming growth factor, beta receptor II (70/80kDa) (TGFBR2)
  • transforming growth factor, beta receptor II (TGFBR2)
  • transforming growth factor, beta receptor II (70/80kDa) (LOC100220619)
  • transforming growth factor beta receptor II (LOC100038019)
  • transforming growth factor, beta receptor II (Tgfbr2)
  • transforming growth factor, beta receptor II-like (LOC424261)
  • 1110020H15Rik protein
  • AAT3 protein
  • AU042018 protein
  • DNIIR protein
  • FAA3 protein
  • LDS1B protein
  • LDS2B protein
  • MFS2 protein
  • RIIC protein
  • RIIDN protein
  • TAAD2 protein
  • TBETA-RII protein
  • TbetaR-II protein
  • TbetaRII protein
  • TBR-II protein
  • TGF-beta 2 protein
  • TGFbeta-RII protein
  • TGFBR2 protein
  • Tgfbr2T protein
  • TGFBRII protein
  • TGFR-2 protein

Protein level used designations for TGFBR2

transforming growth factor, beta receptor II (70/80kDa) , transforming growth factor beta type II receptor , transforming growth factor, beta receptor II , transforming growth factor beta receptor 2 , TGF-beta receptor type-2 , TGF beta receptor type II , TGF-beta receptor type-2-like , TGF-beta receptor II , TGF-beta receptor type II , TGF-beta type II receptor , TGFR-2 , transforming growth factor-beta receptor type II , tbetaR-II , transforming growth factor beta receptor type II , transforming growth factor beta, receptor 2 , transforming growth factor, beta receptor 2 , transforming growth factor, beta receptor IIT , transforming growth factor-b type II receptor , transforming growth factor-beta type II receptor , TGF-beta receptor type IIB , transforming growth factor beta receptor type IIC

GENE ID SPECIES
460243 Pan troglodytes
477039 Canis lupus familiaris
494191 Ovis aries
703088 Macaca mulatta
100031897 Monodelphis domestica
100033860 Equus caballus
100076965 Ornithorhynchus anatinus
100404359 Callithrix jacchus
100459236 Pongo abelii
100482939 Ailuropoda melanoleuca
100220619 Taeniopygia guttata
100606849 Nomascus leucogenys
100038019 Sus scrofa
21813 Mus musculus
81810 Rattus norvegicus
396399 Gallus gallus
7048 Homo sapiens
535376 Bos taurus
424261 Gallus gallus
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