Transforming Growth Factor, beta Receptor II (70/80kDa) Proteins (TGFBR2)

TGFBR2 encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. Additionally we are shipping TGFBR2 Antibodies (218) and TGFBR2 Kits (38) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TGFBR2 21813 Q62312
TGFBR2 81810 P38438
TGFBR2 7048 P37173
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Top TGFBR2 Proteins at antibodies-online.com

Showing 10 out of 33 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Rhesus Monkey Fc Tag 50 μg Log in to see 20 to 21 Days
$382.80
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$4,244.78
Details
HOST_Human Cells Human Fc Tag,His tag 50 μg Log in to see 20 to 21 Days
$382.80
Details
HOST_HEK-293 Cells Human Fc Tag Human TGF-beta RII, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. 100 μg Log in to see 2 to 3 Days
$346.50
Details
HOST_Human Cells Rat Fc Tag 100 μg Log in to see 20 to 21 Days
$382.80
Details
HOST_Mammalian Cells Human Fc Tag   50 μg Log in to see 4 Days
$385.00
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
HOST_Human Human Fc Tag   10 μg Log in to see 15 to 16 Days
$225.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details

TGFBR2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) , , ,
, , ,
Rat (Rattus) ,
,
Human , , , , , , , ,
, , , , ,

Top referenced TGFBR2 Proteins

  1. Human TGFBR2 Protein expressed in Human Cells - ABIN2002668 : Lin, Wang, Ng-Eaton, Weinberg, Lodish: Expression cloning of the TGF-beta type II receptor, a functional transmembrane serine/threonine kinase. in Cell 1992 (PubMed)
    Show all 6 Pubmed References

More Proteins for Transforming Growth Factor, beta Receptor II (70/80kDa) (TGFBR2) Interaction Partners

Rhesus Monkey Transforming Growth Factor, beta Receptor II (70/80kDa) (TGFBR2) interaction partners

  1. Expression of microRNA miR (show MYLIP Proteins)-155 was significantly upregulated in the oropharyngeal mucosa during chronic SIV infection and was coincident with downregulation of TGFbeta (show TGFB1 Proteins) receptor 2 (TGFbeta (show TGFB1 Proteins)-R2) and SMAD5 (show SMAD5 Proteins).

Mouse (Murine) Transforming Growth Factor, beta Receptor II (70/80kDa) (TGFBR2) interaction partners

  1. PAR1 (show F2R Proteins) in its inactive unligated state functions as a scaffold for TGFbetaRII to downregulate TGF-beta (show TGFB1 Proteins) signaling, and thereby promote embryonic stem cell transition to functional endothelial cells.

  2. Cell-intrinsic TGFbeta-RII signaling limits CD4 (show CD4 Proteins) T cell proliferation but not prototypical T helper subset differentiation early after chronic lymphocytic choriomeningitis virus infection.

  3. These results suggest that DMSO, a fusogenic substance, enhances TGF-beta (show TGFB1 Proteins) activity presumably by inducing fusion of cytoplasmic vesicles (containing TbetaR-II) and the plasma membrane, resulting in increased localization of TbetaR-II to non-lipid raft microdomains where canonical signaling occurs.

  4. USP11 (show USP11 Proteins) may contribute to the pathogenesis of pulmonary fibrosis by stabilization of TbetaRII and promotion of TGFbeta (show TGFB1 Proteins)-1 signaling.

  5. both GDF-15 (show GDF15 Proteins) and TGF-beta1 (show TGFB1 Proteins) counteract chemokine (show CCL1 Proteins)-induced integrin activation on neutrophils via the ALK-5 (show TGFBR1 Proteins)/TGF-betaRII heterodimer.

  6. Knockout of the TGFbeta (show TGFB1 Proteins) receptor in proopiomelanocortin (show POMC Proteins) neurons counteracts the hypertensive effect of not only TGFbeta (show TGFB1 Proteins) but also mtDNA excess, while the hypertensive action of central mtDNA can be blocked pharmacologically by a TGFbeta (show TGFB1 Proteins) receptor antagonist or genetically by TGFbeta (show TGFB1 Proteins) receptor knockout.

  7. Postnatal disruption of Tgfbr2 gene compromises extracellular matrix properties and promotes aortic dissection, which can be prevented by rapamycin treatment.

  8. Gasdermin C is upregulated by inactivation of Tgfbr2 in the presence of mutated Apc (show APC Proteins), promoting colorectal cancer cell proliferation.

  9. In the presence of gadolinium and antibeta1 integrin antibody, collagen regulated the expression levels of Tgfbr1 (show TGFBR1 Proteins), Tgfbr2 and Smad2 (show SMAD2 Proteins)/3, but did not alter the phosphorylation of p38 (show CRK Proteins), ERK1/2 or JNK (show MAPK8 Proteins).

  10. Epithelial TGFbeta (show TGFB1 Proteins) signaling via TGFBR2 does not contribute to the development of liver fibrosis or formation of hepatocellular carcinomas in mice, but restricts cholangiocyte proliferation to prevent cholangiocarcinoma development.

Human Transforming Growth Factor, beta Receptor II (70/80kDa) (TGFBR2) interaction partners

  1. we describe and characterize the functional impact of a novel VUS in the TGFBR2 kinase domain (c.1255G>T; p.Val419Leu), in a patient with the clinical diagnosis of Marfan syndrome spectrum. Our results establish that the V419L variant leads to aberrant TGF-beta (show TGFB1 Proteins) signaling and confirm the diagnosis of Loeys-Dietz syndrome in this patient.

  2. Apo (show C9orf3 Proteins) and inhibitor-bound TGFBR2 kinase structures are presented at high resolution (<2 A).

  3. Aortic diseases in patients with TGFBR1 (show TGFBR1 Proteins) or TGFBR2 mutations show the same prevalence of systemic features and the same global survival.

  4. TGF-beta (show TGFB1 Proteins) type I, II, and III receptors were all identified in pregnant serum; all were substantially elevated in early-onset but not late-onset PE. Endoglin (show ENG Proteins) was increased in both subtypes.

  5. Although TGFbeta1 (show TGFB1 Proteins)/2 receptors are downregulated in breast cancer, their expression in tumors is an indicator of aggressive breast cancer phenotype.

  6. this is the first clinical report to demonstrate a potential causal association between TGFB2 (show TGFB2 Proteins) gene mutations and aortic root dilatation in combination with the myxomatous degeneration of both atrioventricular valves.

  7. USP11 (show USP11 Proteins) may contribute to the pathogenesis of pulmonary fibrosis by stabilization of TbetaRII and promotion of TGFbeta (show TGFB1 Proteins)-1 signaling.

  8. Molecular modeling and molecular dynamic simulation of the effects of variants in the TGFBR2 kinase domain as a paradigm for interpretation of variants obtained by next generation sequencing.

  9. A novel mutation in the TGFBR2 gene was identified in a patient with Loeys-Dietz syndrome.

  10. ZNF32 (show ADRA2A Proteins) was found to directly bind to the TGF-betaR2 (transforming growth factor-beta receptor 2) promoter to promote its expression.

Cow (Bovine) Transforming Growth Factor, beta Receptor II (70/80kDa) (TGFBR2) interaction partners

  1. These results indicate that high plasma cholesterol levels may contribute to the pathogenesis of certain diseases (e.g., atherosclerosis) by suppressing TGF-beta (show TGFB1 Proteins) responsiveness.

TGFBR2 Protein Profile

Protein Summary

This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized.

Gene names and symbols associated with TGFBR2

  • transforming growth factor, beta receptor II (70/80kDa) (TGFBR2)
  • transforming growth factor, beta receptor II (TGFBR2)
  • transforming growth factor, beta receptor II (70/80kDa) (LOC100220619)
  • transforming growth factor beta receptor II (LOC100038019)
  • transforming growth factor, beta receptor II (Tgfbr2)
  • transforming growth factor, beta receptor II-like (LOC424261)
  • 1110020H15Rik protein
  • AAT3 protein
  • AU042018 protein
  • DNIIR protein
  • FAA3 protein
  • LDS1B protein
  • LDS2B protein
  • MFS2 protein
  • RIIC protein
  • RIIDN protein
  • TAAD2 protein
  • TBETA-RII protein
  • TbetaR-II protein
  • TbetaRII protein
  • TBR-II protein
  • TGF-beta 2 protein
  • TGFbeta-RII protein
  • TGFBR2 protein
  • Tgfbr2T protein
  • TGFBRII protein
  • TGFR-2 protein

Protein level used designations for TGFBR2

transforming growth factor, beta receptor II (70/80kDa) , transforming growth factor beta type II receptor , transforming growth factor, beta receptor II , transforming growth factor beta receptor 2 , TGF-beta receptor type-2 , TGF beta receptor type II , TGF-beta receptor type-2-like , TGF-beta receptor II , TGF-beta receptor type II , TGF-beta type II receptor , TGFR-2 , transforming growth factor-beta receptor type II , tbetaR-II , transforming growth factor beta receptor type II , transforming growth factor beta, receptor 2 , transforming growth factor, beta receptor 2 , transforming growth factor, beta receptor IIT , transforming growth factor-b type II receptor , transforming growth factor-beta type II receptor , TGF-beta receptor type IIB , transforming growth factor beta receptor type IIC

GENE ID SPECIES
460243 Pan troglodytes
477039 Canis lupus familiaris
494191 Ovis aries
703088 Macaca mulatta
100031897 Monodelphis domestica
100033860 Equus caballus
100076965 Ornithorhynchus anatinus
100404359 Callithrix jacchus
100459236 Pongo abelii
100482939 Ailuropoda melanoleuca
100220619 Taeniopygia guttata
100606849 Nomascus leucogenys
100038019 Sus scrofa
21813 Mus musculus
81810 Rattus norvegicus
396399 Gallus gallus
7048 Homo sapiens
535376 Bos taurus
424261 Gallus gallus
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