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TGFB1I1 encodes a coactivator of the androgen receptor, a transcription factor which is activated by androgen and has a key role in male sexual differentiation. Additionally we are shipping TGFB1I1 Antibodies (50) and TGFB1I1 Proteins (11) and many more products for this protein.
As aging increased, more ARA55 were expressed in PZ stromal cells, leading to more sensitive androgen/androgen receptor (AR (show AR ELISA Kits)) signal pathway, then constituting a more feasible environment to cancer cells.
Hic-5 appears to enhance complex formation between MT1-MMP (show MMP14 ELISA Kits) and FAK (show PTK2 ELISA Kits) in activated endothelial cells, which likely coordinates matrix proteolysis and cell motility.
Hic-5 plays a central role in the positive feedback ROS (show ROS1 ELISA Kits)-JNK (show MAPK8 ELISA Kits) signaling cascade that regulates hepatocellular carcinoma progression.
Hic-5 influences the genomic occupancy of multiple steroid receptors and thereby blocks some aspects of hormonal regulation.
Endothelial Hic-5 plays an important role in the formation of microvilli-like structures and in the interaction between ECs and monocytes, leading to monocyte recruitment and subsequent development of atherosclerosis.
Studies in vitro and in vivo using TGF-beta1 (show TGFB1 ELISA Kits) and TGFB1I1 shRNA demonstrated that TGFB1I1 is required for TGF-beta (show TGFB1 ELISA Kits) stimulated EMT (show ITK ELISA Kits) that contributes to malignant progression of astrocytomas.
Hic-5 siRNA also suppressed TGF-beta2 (show TGFB2 ELISA Kits)-induced fibrogenic activity and dexamethasone-induced myocilin (show MYOC ELISA Kits) expression in HTM cells.
Hic5 coordinates AR signaling with adhesion and extracellular matrix contacts to regulate cell behavior in the tumor microenvironment.
Hic-5 suppresses senescence and profibrotic activities of myofibroblasts by down-regulating Nox4 (show NOX4 ELISA Kits) expression.
The ubiquitin ligase activity of Cbl (show CBL ELISA Kits)-c by the direct interaction of the LIM (show PDLIM5 ELISA Kits) zinc coordinating domain of Hic5 is demonstrated.
Hic-5 deficiency attenuates the activation of hepatic stellate cells and liver fibrosis though reducing the TGF-beta (show TGFB1 ELISA Kits)/Smad2 (show SMAD2 ELISA Kits) signaling by upregulation of Smad7 (show SMAD7 ELISA Kits)
Hic-5 regulates mesangial cell proliferation in proliferative glomerulonephritis in mice.
Hic-5 is a transcription coregulator that acts before and/or after glucocorticoid receptor (show NR3C1 ELISA Kits) genome occupancy in a gene-selective manner.
Hic-5 is expressed in B16-F1 murine melanoma cells.
identified Hic-5 as a novel and specific regulatory factor for thrombin (show F2 ELISA Kits)-induced alphaIIbbeta3 activation and subsequent platelet aggregation in mice.
the HIC-5- and KLF4 (show KLF4 ELISA Kits)-dependent mechanism transactivates p21(Cip1 (show CDKN1A ELISA Kits)) in response to anchorage loss
These data identify discrete roles for paxillin (show PXN ELISA Kits) and Hic-5 in Rac1 and RhoA (show RHOA ELISA Kits)-dependent cell adhesion formation and maturation; processes essential for productive cell migration.
Transforming growth factor-beta1-induced transcript 1 protein, a novel marker for smooth muscle contractile phenotype, is regulated by serum response factor/myocardin (show MYOCD ELISA Kits) protein.
DNA-binding domain acetylation in the TR4 (show NR2C2 ELISA Kits) nuclear receptor by the coregulator ARA55 leads to suppression of TR4 (show NR2C2 ELISA Kits) transactivation
This gene encodes a coactivator of the androgen receptor, a transcription factor which is activated by androgen and has a key role in male sexual differentiation. The encoded protein is thought to regulate androgen receptor activity and may have a role to play in the treatment of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
transforming growth factor beta 1 induced transcript 1
, androgen receptor coactivator ARA55
, transforming growth factor beta-1-induced transcript 1 protein-like
, androgen receptor coactivator 55 kDa protein
, androgen receptor-associated protein of 55 kDa
, hydrogen peroxide-inducible clone 5 protein
, transforming growth factor beta-1-induced transcript 1 protein
, TGF beta-stimulated clone 5
, androgen receptor activator of 55 kDa