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The protein encoded by TAGLN is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Additionally we are shipping Transgelin Kits (19) and Transgelin Proteins (17) and many more products for this protein.
Showing 10 out of 182 products:
Human Polyclonal Transgelin Primary Antibody for ELISA, WB - ABIN153392
Nishida, Kitami, Abe, Hiwada: Gene cloning and nucleotide sequence of SM22 alpha from the chicken gizzard smooth muscle. in Biochemistry international 1991
Show all 19 Pubmed References
Human Polyclonal Transgelin Primary Antibody for ELISA, WB - ABIN185188
Donati, Marseglia, Magi, Serratì, Cencetti, Bernacchioni, Nannetti, Benelli, Brunelli, Torricelli, Cossu, Bruni: Sphingosine 1-phosphate induces differentiation of mesoangioblasts towards smooth muscle. A role for GATA6. in PLoS ONE 2011
Show all 5 Pubmed References
Human Monoclonal Transgelin Primary Antibody for ELISA - ABIN948518
Canducci, Saita, Foglieni, Piscopiello, Chiesa, Colombo, Cianflone, Maseri, Clementi, Burioni: Cross-reacting antibacterial auto-antibodies are produced within coronary atherosclerotic plaques of acute coronary syndrome patients. in PLoS ONE 2012
Human Polyclonal Transgelin Primary Antibody for ICC, IF - ABIN4362001
Isella, Terrasi, Bellomo, Petti, Galatola, Muratore, Mellano, Senetta, Cassenti, Sonetto, Inghirami, Trusolino, Fekete, De Ridder, Cassoni, Storme, Bertotti, Medico: Stromal contribution to the colorectal cancer transcriptome. in Nature genetics 2015
Human Polyclonal Transgelin Primary Antibody for ICC, IF - ABIN442948
Shi, Srivastava, Kanasaki, He, Kitada, Nagai, Nitta, Takagi, Kanasaki, Koya: Interactions of DPP-4 and integrin β1 influences endothelial-to-mesenchymal transition. in Kidney international 2015
Data (including data from studies using cells cultured from transgenic/knockout mice) suggest that expression and degradation of transgelin in myofibroblasts and keratinocytes are regulated by mechanical tension in cytoskeleton produced by myosin II motor in response to stiffness of culture matrix/extracellular matrix.
transgelin (TAGLN), a transforming growth factor beta (TGFbeta (show TGFB1 Antibodies))-inducible gene, was identified as an upregulated gene during in vitro osteoblastic and adipocytic differentiation of human bone marrow-derived stromal (skeletal) stem cells
regulates vasculogenic mimicry in breast cancer cells by enhancing interleukin-8 (show IL8 Antibodies) uptake
Serum concentrations of CK-18 (show KRT18 Antibodies) fragments and transgelin-2 (show TAGLN2 Antibodies) correlate with the severity of NAFLD (show TSC2 Antibodies), but not with obesity.
Increases or decreases in transgelin levels have reciprocal effects on tumor cell behavior, with higher expression promoting metastasis
activated AKT (show AKT1 Antibodies) and JNK (show MAPK8 Antibodies) signaling pathways promote the overexpression of transgelin
Cofilin-1 (show CFL1 Antibodies) and transgelin may play roles in the carcinogenesis and development of esophageal squamous cell carcinoma
Both tissue and salivary transgelin mRNA were closely correlated with various important clinicopathological parameters and were independent prognosis factors for oral squamous cell carcinoma.
SM22alpha is a phosphorylation-regulated (show PHAX Antibodies) suppressor of IKK (show CHUK Antibodies)-IkappaBalpha (show NFKBIA Antibodies)-NF-kappaB (show NFKB1 Antibodies) signaling cascades.
EZH2 (show EZH2 Antibodies) regulates the chromatin structure at the TAGLN promoter through tri (show VANGL2 Antibodies)-methylation of H3K27, acting as an epigenetic integrator of IL-1beta (show IL1B Antibodies) and TGFbeta2 signaling.
Targeted elimination of TGFbetaR2 in TAGLN(+) cells impairs midline closure and prevents the correct subsequent patterning of the musculature and skeletal components.
SM22alpha promotes ubiquitination and degradation of MKP3 (show DUSP6 Antibodies). SM22alpha facilitates AngII-induced contraction by maintenance of ERK1/2 (show MAPK1/3 Antibodies) signaling.
TRAF6 (show TRAF6 Antibodies)-SM22alpha-G6PD (show G6PD Antibodies) pathway is a novel mechanism underlying the association between glucose metabolism and VSMC survival, which is beneficial for vascular repair after injury but facilitates atherosclerotic plaque stability.
Absent/lower SM22 alpha levels favor an increase in parietal epithelial cell transition cells and PECs expressing a progenitor marker, and a lower epithelial mesenchymal transformation rate versus SM22alpha+/+mice, where SM22 levels are increased in PECs.
SM22alpha-regulated molecular pathways contribute to vascular pathology.
Histological analysis did not reveal calcium deposits in the aortic roots of SM22alpha-Rankl (show TNFSF11 Antibodies) ( tg ) mice
Data show that formation of a Krupple-like factor KLF4 (show KLF4 Antibodies), pELK-1, and histone de-acetylase 2 (HDAC2 (show HDAC2 Antibodies)) multiprotein complex dependent on the SM22alpha G/C Repressor element.
Data suggest that SM22alpha expression in renal tissues might be a hallmark of kidney diseases.
The protein encoded by this gene is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Its expression is down-regulated in many cell lines, and this down-regulation may be an early and sensitive marker for the onset of transformation. A functional role of this protein is unclear. Two transcript variants encoding the same protein have been found for this gene.
, putative transgelin
, 22 kDa actin-binding protein
, smooth muscle protein 22-alpha
, transgelin variant 2
, actin-associated protein p27
, smooth muscle 22 protein
, 25 kDa F-actin-binding protein