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The protein encoded by TAGLN is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Additionally we are shipping Transgelin Proteins (19) and Transgelin Kits (18) and many more products for this protein.
Showing 10 out of 170 products:
Human Polyclonal Transgelin Primary Antibody for ELISA, WB - ABIN153392
Nishida, Kitami, Abe, Hiwada: Gene cloning and nucleotide sequence of SM22 alpha from the chicken gizzard smooth muscle. in Biochemistry international 1991
Show all 19 references for ABIN153392
Cow (Bovine) Polyclonal Transgelin Primary Antibody for EIA, WB - ABIN374407
Donati, Marseglia, Magi, Serratì, Cencetti, Bernacchioni, Nannetti, Benelli, Brunelli, Torricelli, Cossu, Bruni: Sphingosine 1-phosphate induces differentiation of mesoangioblasts towards smooth muscle. A role for GATA6. in PLoS ONE 2011
Show all 13 references for ABIN374407
Human Polyclonal Transgelin Primary Antibody for ELISA, WB - ABIN185188
Donoghue, Doran, Wynne, Pedersen, Dunn, Ohlendieck: Proteomic profiling of chronic low-frequency stimulated fast muscle. in Proteomics 2007
Show all 5 references for ABIN185188
Human Monoclonal Transgelin Primary Antibody for WB - ABIN394479
Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. in Diabetes Care 2010
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Human Polyclonal Transgelin Primary Antibody for EIA, WB - ABIN453404
Zhao, Wang, Deng, Wang, Liu, Jin, Ding: Transgelin as a suppressor is associated with poor prognosis in colorectal carcinoma patients. in Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2009
Show all 3 references for ABIN453404
Human Polyclonal Transgelin Primary Antibody for EIA, WB - ABIN453405
Léguillette, Laviolette, Bergeron, Zitouni, Kogut, Solway, Kachmar, Hamid, Lauzon: Myosin, transgelin, and myosin light chain kinase: expression and function in asthma. in American journal of respiratory and critical care medicine 2009
Show all 3 references for ABIN453405
Human Monoclonal Transgelin Primary Antibody for ELISA, WB - ABIN520665
Canducci, Saita, Foglieni, Piscopiello, Chiesa, Colombo, Cianflone, Maseri, Clementi, Burioni: Cross-reacting antibacterial auto-antibodies are produced within coronary atherosclerotic plaques of acute coronary syndrome patients. in PLoS ONE 2012
Human Polyclonal Transgelin Primary Antibody for ICC, IF - ABIN442948
Shi, Srivastava, Kanasaki, He, Kitada, Nagai, Nitta, Takagi, Kanasaki, Koya: Interactions of DPP-4 and integrin β1 influences endothelial-to-mesenchymal transition. in Kidney international 2015
Serum concentrations of CK-18 (show KRT18 Antibodies) fragments and transgelin-2 (show TAGLN2 Antibodies) correlate with the severity of NAFLD (show TSC2 Antibodies), but not with obesity.
Increases or decreases in transgelin levels have reciprocal effects on tumor cell behavior, with higher expression promoting metastasis
activated AKT (show AKT1 Antibodies) and JNK (show MAPK8 Antibodies) signaling pathways promote the overexpression of transgelin
Cofilin-1 (show CFL1 Antibodies) and transgelin may play roles in the carcinogenesis and development of esophageal squamous cell carcinoma
Both tissue and salivary transgelin mRNA were closely correlated with various important clinicopathological parameters and were independent prognosis factors for oral squamous cell carcinoma.
SM22alpha is a phosphorylation-regulated (show PHAX Antibodies) suppressor of IKK (show CHUK Antibodies)-IkappaBalpha (show NFKBIA Antibodies)-NF-kappaB (show NFKB1 Antibodies) signaling cascades.
EZH2 (show EZH2 Antibodies) regulates the chromatin structure at the TAGLN promoter through tri (show VANGL2 Antibodies)-methylation of H3K27, acting as an epigenetic integrator of IL-1beta (show IL1B Antibodies) and TGFbeta2 signaling.
Transgelin may be an excellent diagnostic marker of Triple negative tumors and could be useful in stratification of patients
Results indicate that miR (show MLXIP Antibodies)-144 may regulate osteosarcoma cell proliferation and invasion by downregulating its target gene, transgelin protein (TAGLN), suggesting that miR (show MLXIP Antibodies)-144 may be a potential therapeutic target for the treatment of osteosarcoma.
TAGLN was highly expressed in NF1 (show NF1 Antibodies)-deficient malignant peripheral nerve sheath tumors compared to NF1 (show NF1 Antibodies)-deficient plexiform neurofibromas. Upregulation was caused by increased transcriptional expression. The TAGLN gene was hypomethylated in the MPNST cells.
SM22alpha promotes ubiquitination and degradation of MKP3 (show DUSP6 Antibodies). SM22alpha facilitates AngII-induced contraction by maintenance of ERK1/2 (show MAPK1/3 Antibodies) signaling.
TRAF6 (show TRAF6 Antibodies)-SM22alpha-G6PD (show G6PD Antibodies) pathway is a novel mechanism underlying the association between glucose metabolism and VSMC survival, which is beneficial for vascular repair after injury but facilitates atherosclerotic plaque stability.
Absent/lower SM22 alpha levels favor an increase in parietal epithelial cell transition cells and PECs expressing a progenitor marker, and a lower epithelial mesenchymal transformation rate versus SM22alpha+/+mice, where SM22 levels are increased in PECs.
SM22alpha-regulated molecular pathways contribute to vascular pathology.
Histological analysis did not reveal calcium deposits in the aortic roots of SM22alpha-Rankl (show TNFSF11 Antibodies) ( tg ) mice
Data show that formation of a Krupple-like factor KLF4 (show KLF4 Antibodies), pELK-1, and histone de-acetylase 2 (HDAC2 (show HDAC2 Antibodies)) multiprotein complex dependent on the SM22alpha G/C Repressor element.
Data suggest that SM22alpha expression in renal tissues might be a hallmark of kidney diseases.
We conclude that the de novo expression of SM22alpha in glomerular epithelial cells affects the course of crescentic glomerulonephritis.
critical role for the Tsc1 (show TSC1 Antibodies)/Tsc2 (show TSC2 Antibodies)-mTORC1-S6K (show RPS6KB1 Antibodies) axis in the normal development of cardiovascular tissue
The protein encoded by this gene is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Its expression is down-regulated in many cell lines, and this down-regulation may be an early and sensitive marker for the onset of transformation. A functional role of this protein is unclear. Two transcript variants encoding the same protein have been found for this gene.
, putative transgelin
, 22 kDa actin-binding protein
, smooth muscle protein 22-alpha
, transgelin variant 2
, actin-associated protein p27
, smooth muscle 22 protein
, 25 kDa F-actin-binding protein