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The protein encoded by TRPC1 is a membrane protein that can form a non-selective channel permeable to calcium and other cations. Additionally we are shipping Transient Receptor Potential Cation Channel, Subfamily C, Member 1 Proteins (6) and Transient Receptor Potential Cation Channel, Subfamily C, Member 1 Kits (2) and many more products for this protein.
Showing 10 out of 67 products:
Rat (Rattus) Polyclonal TRPC1 Primary Antibody for IHC, WB - ABIN351117
Lockwich, Liu, Singh, Jadlowiec, Weiland, Ambudkar: Assembly of Trp1 in a signaling complex associated with caveolin-scaffolding lipid raft domains. in The Journal of biological chemistry 2000
Show all 6 references for ABIN351117
Human Polyclonal TRPC1 Primary Antibody for EIA, WB - ABIN955337
Bomben, Sontheimer: Disruption of transient receptor potential canonical channel 1 causes incomplete cytokinesis and slows the growth of human malignant gliomas. in Glia 2010
Show all 5 references for ABIN955337
Human Polyclonal TRPC1 Primary Antibody for ELISA, WB - ABIN563261
Zhang, Wang, Pan, Xu, Zhang: Measuring Ca2+ influxes of TRPC1-dependent Ca2+ channels in HL-7702 cells with non-invasive micro-test technique. in World journal of gastroenterology : WJG 2009
Show all 2 references for ABIN563261
Endogenous as well as overexpressed xTRPV6 interacts with xTRPC1.
our results suggest that calcium influx through mechanosensitive TRPC1 channels on filopodia activates calpain to control growth cone turning during development.
This study suggested that BDNF (show BDNF Antibodies)-induced synaptic potentiation involves coordinated presynaptic and postsynaptic responses and identifies TRPC1 as a molecular mediator for postsynaptic Ca2 (show CA2 Antibodies)+ elevation required for BDNF (show BDNF Antibodies)-induced synaptic plasticity.
XTRPC1, a Xenopus homolog of mammalian TRPC1, is required for proper growth cone turning responses of Xenopus spinal neurons to netrin-1 (show NTN1 Antibodies), brain-derived neurotrophic factor (show BDNF Antibodies) and myelin-associated glycoprotein (show MAG Antibodies), but not to semaphorin 3A (show SEMA3A Antibodies).
downregulation of Xenopus TRP-1 (show TYRP1 Antibodies) (xTRPC1) expression with a specific morpholino oligonucleotide abolished the growth-cone turning and Ca2 (show CA2 Antibodies)+ elevation induced by a netrin-1 (show NTN1 Antibodies) gradient
These results provide the first in vivo evidence that TRPC1 is essential for angiogenesis in zebrafish.
a novel activation mechanism for TRPC1 SOCs in VSMCs, in which store depletion induces formation of TRPC1-Galphaq-PLCbeta1 complexes that lead to PKC stimulation and channel gating.
SARAF (show TMEM66 Antibodies) modulates TRPC1, but not TRPC6 (show TRPC6 Antibodies), channel function in a STIM1 (show STIM1 Antibodies)-independent manner
These findings suggest identification of an important experimental tool compound, which has much higher potency for inhibiting TRPC1/4/5 channels than previously reported agents, impressive specificity, and graded subtype selectivity within the TRPC1/4/5 channel family.
changes in cell cycle regulating genes in TRPC1-silenced cells indicate possible cell cycle arrest along with compensatory up-regulation of ERBB3 (show ERBB3 Antibodies) growth factor receptor (show RYK Antibodies)-amongst others-to maintain hepatocellular carcinoma cell proliferation.
OC. Our results provide the basis for further investigations of the drug-resistance-related functions of TRPC1 in ovarian cancer and other forms of cancer.
TRPC1 mRNA and protein levels were increased in FCDIa, FCDIIa, and FCDIIb patients.
HIF-1alpha (show HIF1A Antibodies) knockdown attenuated hypoxia-induced BMP4 (show BMP4 Antibodies) expression and knockdown of either HIF-1alpha (show HIF1A Antibodies) or BMP4 (show BMP4 Antibodies) abolished hypoxia-induced TRPC expression and basal [Ca(2 (show CA2 Antibodies)+)]i.
Single nucleotide polymorphisms in TYRP1 (show TYRP1 Antibodies) gene is associated with multiple primary melanoma.
In c-kit (show KIT Antibodies)+ cardiac progenitor cells, silencing TRPC1 significantly reduced the Ca2 (show CA2 Antibodies)+ signaling through store-operated Ca2 (show CA2 Antibodies)+ channels, decreased cell proliferation and migration, and reduced expression of cyclin D1 (show CCND1 Antibodies), cyclin E (show CCNE1 Antibodies), and/or p-Akt (show AKT1 Antibodies).
RhoA (show RHOA Antibodies) interacts with and activates TRPC1 and thus stimulates rapid epithelial restitution after injury by inducing Ca(2 (show CA2 Antibodies)+) signaling.
TRPC1 may take part both in regulation of store-operated Ca(2 (show CA2 Antibodies)+) entry and proliferation of hepatocellular carcinoma cells.
these data indicate for the first time a functional interaction between Orai1 (show TMEM132A Antibodies), TRPC1, and CaV1.2 (show CACNA1C Antibodies) channels in Vascular Smooth Muscle Cells, confirming that upon agonist stimulation, vessel contraction involves Ca(2 (show CA2 Antibodies)+) entry due to co-activation of Orai1 (show TMEM132A Antibodies)- and TRPC1-dependent store-operated Ca(2 (show CA2 Antibodies)+) channels and L-type Ca(2 (show CA2 Antibodies)+) channels.
mechanosensitive TRPC1 channels in murine PSCs exposed to elevated ambient pressure
The results of this study showed that Loss of TRPC1 facilitated the gliotic response induced by increased intraocular pressure (IOP), suggesting that the channel might contribute to the glial mechanosusceptibility.
transient receptor potential channel 1 suppression of basal sphingosine kinase 1 (show SPHK1 Antibodies) activity enables endothelial cell-barrier destabilization by edemagenic agonists
Together the data suggests that Ca(2 (show CA2 Antibodies)+) entry via the TRPC1 channels is essential for the activation of CaCC (show CLCA1 Antibodies)
TRPC1(-/-) mice exhibited decreased survival, severe lung injury, and systemic bacterial dissemination upon infection.
TRPC1 controls the activity of further Ca(2 (show CA2 Antibodies)) influx channels and thus regulates the maintenance of intracellular Ca(2 (show CA2 Antibodies)) gradients which are critical for cell migration.
Soleus muscle TRPC1 mRNA was unaltered during the hindlimb unloading-reloading period. However, protein expression remained depressed through the reloading process. Decreased localization of TRPC1 to the sarcolemma was observed.
These results suggest that the AR region of TRPC3 (show TRPC3 Antibodies) could mediate the heteromeric TRPC3 (show TRPC3 Antibodies)/1 formation, and the heteromeric TRPC3 (show TRPC3 Antibodies)/1 could participate in regulating the resting cytosolic Ca(2 (show CA2 Antibodies)+) levels in skeletal muscle.
TRPC1 participates in the pathophysiological development of hypoxic pulmonary hypertension in the mouse model.
the link between HG-induced changes in TRPC1 expression, enhanced Ca(2 (show CA2 Antibodies)+) entry, and endothelial dysfunction require further study
Demonstrate a novel role of the NO-cGMP-PKG (show PRKG1 Antibodies) pathway in the inhibition of 11,12-EET-induced smooth muscle hyperpolarization and relaxation via PKG (show PRKG1 Antibodies)-mediated phosphorylation of TRPC1.
Data found that the pig adrenal medulla expressed predominantly TRPC1, TRPC5 (show TRPC5 Antibodies), and TRPC6 (show TRPC6 Antibodies) transcripts. The expression level of these TRPCs was significantly elevated in the adrenal medulla from pigs with metabolic syndrome.
This gene encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Defects in this gene are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III.
transient receptor potential protein
, short transient receptor potential channel 1
, transient receptor potential cation channel, subfamily C, member 1
, transient receptor potential cation channel subfamily C member 1
, short transient receptor potential channel 1-like
, calcium influx channel TRPC1A
, putative calcium influx channel TRPC1A
, transient receptor potential canonical 1
, transient receptor protein 1
, trp-related protein 1
, transient receptor potential channel 1
, store-operated calcium channel
, transient receptor potential channel subfamily C member 1
, 5,6-dihydroxyindole-2-carboxylic acid oxidase
, DHICA oxidase
, catalase B
, glycoprotein 75
, melanoma antigen gp75