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Transient Receptor Potential Cation Channel, Subfamily C, Member 4 Proteins (TRPC4)

TRPC4 encodes a member of the canonical subfamily of transient receptor potential cation channels. Additionally we are shipping TRPC4 Antibodies (130) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TRPC4 7223 Q9UBN4
TRPC4 22066 Q9QUQ5
Rat TRPC4 TRPC4 84494  
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Top TRPC4 Proteins at antibodies-online.com

Showing 4 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details

TRPC4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine) ,
,

More Proteins for Transient Receptor Potential Cation Channel, Subfamily C, Member 4 (TRPC4) Interaction Partners

Human Transient Receptor Potential Cation Channel, Subfamily C, Member 4 (TRPC4) interaction partners

  1. slow phase of Gi/o-mediated TRPC4 activation was diminished by inhibiting RhoA (show RHOA Proteins) or enhancing PLCdelta function

  2. Studies indicate potential roles for Rasd1 (show RASD1 Proteins) small G protein (show RAC2 Proteins) and leptin (show LEP Proteins) in TRPC4 cation channel (show TRPV1 Proteins) activation.

  3. Galpha (show SUCLG1 Proteins)(i2) activates the TRPC4 channel by direct binding.

  4. This study identifies a novel role for TRPC4 in the regulation of autophagy in vascular endothelial cells.

  5. The higher amplitude of store-operated Ca2 (show CA2 Proteins)+ entry was associated to the over-expression for Stim2 (show Stim2 Proteins), Orai2 (show ORAI2 Proteins)-3, and TRPC1 (show TRPC1 Proteins) while Stim2 (show Stim2 Proteins) levels remained constant and Stim1 (show STIM1 Proteins), Orai1, Orai3, TRPC1 (show TRPC1 Proteins) and TRPC4 proteins were over-expressed in primary myelofibrosis.

  6. a membrane-targeting domain of the transient receptor potential canonical (TRPC)4 channel unrelated to its formation of a tetrameric structure

  7. Tarbp2 (show TARBP2 Proteins) binding to TRPC4 promotes changes of cytosolic Ca(2 (show CA2 Proteins)+) and, thereby, leads to a dynamic regulation of Dicer (show DICER1 Proteins) activity, essentially at low endogenous Dicer (show DICER1 Proteins) concentrations.

  8. the enhanced apoptosis caused by the simultaneous depletion of Dp53 and Dmp52 is absolutely JNK (show MAPK8 Proteins)-dependent.

  9. the S4-S5 linker is a critical constituent of TRPC4/C5 channel gating and that disturbance of its sequence allows channel opening independent of any sensor domain.

  10. an essential role of Galpha (show SUCLG1 Proteins)(i) proteins as novel activators for TRPC4/5 and reveal the molecular mechanism by which G-proteins activate the channels.

Mouse (Murine) Transient Receptor Potential Cation Channel, Subfamily C, Member 4 (TRPC4) interaction partners

  1. the antidepressant and anxiolytic-like effects of a newly identified TRPC4/C5 inhibitor, M084.

  2. TRPC4 knockdownsuppressed the activation of ERK (show EPHB2 Proteins), p38 MAPK (show MAPK14 Proteins) and AKT (show AKT1 Proteins) signalingpathway.

  3. Tarbp2 (show TARBP2 Proteins) binding to TRPC4 promotes changes of cytosolic Ca(2 (show CA2 Proteins)+) and, thereby, leads to a dynamic regulation of Dicer (show DICER1 Proteins) activity, essentially at low endogenous Dicer (show DICER1 Proteins) concentrations.

  4. Changes in ion selectivity and pore dilation of the TRPC4 channel elicited by the Galphai2 (show GNAI2 Proteins) subunit, were studied.

  5. Constitutive ablation of TRPC4 in the amygdala is associated with diminished anxiety levels.

  6. Data suggest that TRPC1 (show TRPC1 Proteins) and TRPC4 are involved in the sprouting of sensory neurons following bladder cystitis, which leads to overactive bladder disease.

  7. Data indicate that kisspeptin activates TRPC4 channels through PIP(2) depletion and cSrc tyrosine kinase activation in GnRH neurons.

  8. the S4-S5 linker is a critical constituent of TRPC4/C5 channel gating and that disturbance of its sequence allows channel opening independent of any sensor domain.

  9. The results of this study suggested that TRPC4, TRPM4 (show TRPM4 Proteins), TRPM8 (show TRPM8 Proteins) and TRPV1 (show TRPV1 Proteins), showed statistically significant variation in mRNA levels between DRGs from different segments, suggesting ganglion-specific regulation of TRP (show TYRP1 Proteins) channel gene expression.

  10. Is unaltered in TRPC5 (show TRPC5 Proteins) KO mice, but is abolished in TRPC1 (show TRPC1 Proteins) KO and TRPC1 (show TRPC1 Proteins)/4 DKO mice.

Cow (Bovine) Transient Receptor Potential Cation Channel, Subfamily C, Member 4 (TRPC4) interaction partners

TRPC4 Protein Profile

Protein Summary

This gene encodes a member of the canonical subfamily of transient receptor potential cation channels. The encoded protein forms a non-selective calcium-permeable cation channel that is activated by Gq-coupled receptors and tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation. Single nucleotide polymorphisms in this gene may be associated with generalized epilepsy with photosensitivity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with TRPC4

  • transient receptor potential cation channel, subfamily C, member 4 (TRPC4)
  • transient receptor potential cation channel, subfamily C, member 4 (trpc4)
  • transient receptor potential cation channel, subfamily C, member 4 (LOC100353818)
  • transient receptor potential cation channel, subfamily C, member 4 (Trpc4)
  • CCE1 protein
  • HTRP-4 protein
  • HTRP4 protein
  • STRPC4 protein
  • Trp4 protein
  • TRPC4 protein
  • TRPC5 protein
  • Trrp4 protein

Protein level used designations for TRPC4

transient receptor potential 4 , transient receptor potential cation channel, subfamily C, member 5 , transient receptor potential cation channel, subfamily C, member 4 , short transient receptor potential channel 4-like , short transient receptor potential channel 4 , trp-related protein 4 , capacitative calcium entry channel Trp4 , putative capacitative calcium entry channel , receptor-activated cation channel TRP4 , transient receptor protein 4 , CCE1 , capacitative calcium entry channel 1 , transient receptor potential channel 4 , transient receptor potential protein 4 , transient receptor potential cation channel TRPC4 middle region 2

GENE ID SPECIES
418895 Gallus gallus
452544 Pan troglodytes
695636 Macaca mulatta
100021320 Monodelphis domestica
100062641 Equus caballus
100078427 Ornithorhynchus anatinus
100408892 Callithrix jacchus
100453863 Pongo abelii
100481526 Ailuropoda melanoleuca
100538928 Meleagris gallopavo
100559243 Anolis carolinensis
100588408 Nomascus leucogenys
100353818 Oryctolagus cuniculus
7223 Homo sapiens
22066 Mus musculus
84494 Rattus norvegicus
100233224 Cavia porcellus
486004 Canis lupus familiaris
100157635 Sus scrofa
282102 Bos taurus
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