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The protein encoded by TRPC6 forms a receptor-activated calcium channel in the cell membrane. Additionally we are shipping Transient Receptor Potential Cation Channel, Subfamily C, Member 6 Antibodies (131) and Transient Receptor Potential Cation Channel, Subfamily C, Member 6 Kits (5) and many more products for this protein.
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These findings suggest that lysoPC induces CaM (show KRIT1 Proteins) phosphorylation at Tyr (show TYR Proteins)(99) by a Src (show SRC Proteins) family kinase and that phosphorylated CaM (show KRIT1 Proteins) activates PI3K to produce PIP3, which promotes TRPC6 translocation to the cell membrane.
analysis of a TRPC6-TRPC5 (show TRPC5 Proteins) channel cascade that restricts endothelial cell movement
study demonstrated that the various mechanisms regulating MDR in HCC (show FAM126A Proteins) cells are calcium dependent through the TRPC6/calcium/STAT3 (show STAT3 Proteins) pathway. We propose that targeting TRPC6 in HCC (show FAM126A Proteins) may be a novel antineoplastic strategy, especially combined with chemotherapy
n response to stretching (20%), ATP was released only from the foremost cells at the wound edge; it then diffused to the cells behind the wound edge and activated the P2Y (show P2RY1 Proteins) receptors, which caused propagating Ca(2 (show CA2 Proteins)+) waves via TRPC6
Data suggest that targeted manipulation of protein kinase C isoforms PKCalpha (show PKCa Proteins), PKCbeta, and PKCeta might be beneficial in certain proteinuric kidney diseases with altered transient receptor potential cation channel subfamily C member 6 protein (TRPC6) functions.
Insulin (show INS Proteins) increases the expression of TRPC6 channels in podocytes by activation of the calcineurin (show PPP3CA Proteins)-dependent pathway.
This study described the expression and functional relevance of TRPC6 in the pathophysiology of HK-2 (show HK2 Proteins) cell following ischemia reperfusion.
Genetic Interactions Between TRPC6 and NPHS1 (show NPHS1 Proteins) Variants Affect Posttransplant Risk of Recurrent Focal Segmental Glomerulosclerosis.
These findings suggest that lysoPC induces CaM (show CALM1 Proteins) phosphorylation at Tyr (show TYR Proteins)(99) by a Src (show SRC Proteins) family kinase and that phosphorylated CaM (show CALM1 Proteins) activates PI3K (show PIK3CA Proteins) to produce PIP3, which promotes TRPC6 translocation to the cell membrane.
This study demonstrated that TRPC6 reduction or haploinsufficiency leads to altered neuronal development, morphology and function.
TRPC6 specifically interacts with APP (show APP Proteins) leading to inhibition of its cleavage by gamma-secretase and reduction in Abeta (show APP Proteins) production.
results suggest that TRPC6 regulates metabolism to affect HIF-1alpha (show HIF1A Proteins) stability and consequent glucose metabolism in human glioma cells under hypoxia
ASIV may prevent HG-induced podocyte apoptosis via downregulation of TRPC6, which is possibly mediated via the calcineurin (show PPP3CA Proteins)/NFAT (show NFATC1 Proteins) signaling pathway.
the mTORC2 (show CRTC2 Proteins)/Akt (show AKT1 Proteins)/NFkappaB pathway-mediated activation of TRPC6 participates in adriamycin-induced podocyte apoptosis.
AngII-injured podocyte had a significant increase in apoptosis, while silencing TRPC6 could decrease the apoptosis induced by AngII.
TRPC3 (show TRPC3 Proteins) and TRPC6 participate diversely in synaptic reorganization in the mossy fiber pathway in temporal lobe epilepsy.
the transient receptor potential canonical-6 (TRPC6) calcium-permeable channel in the alveolar macrophages also functions to shunt the transmembrane potential generated by proton pumping.
Selectively activating endothelial TRPC6 rescues transendothelial migration
MicroRNA-26a prevents endothelial cell apoptosis by directly targeting TRPC6 in the setting of atherosclerosis.
These findings indicate that the mTORC2 (show CRTC2 Proteins) signaling pathway regulates TRPC6 in podocytes but that the mTORC1 signaling pathway does not appear to exert an effect on TRPC6.
these findings provide strong evidence for a role of immunophilins, including FKBP25 (show FKBP3 Proteins) and FKBP38 (show FKBP8 Proteins), in NCCE mediated by TRPC6.
Locally generated Sdc4 (show SDC4 Proteins) may play a role in regulating TRPC6 channels, and may contribute to glomerular pathology.
Data found that the pig adrenal medulla expressed predominantly TRPC1 (show TRPC1 Proteins), TRPC5 (show TRPC5 Proteins), and TRPC6 transcripts. The expression level of these TRPCs was significantly elevated in the adrenal medulla from pigs with metabolic syndrome.
The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2).
transient receptor potential cation channel, subfamily C, member 6
, short transient receptor potential channel 6-like
, short transient receptor potential channel 6
, transient receptor protein 6
, calcium entry channel
, transient receptor potential channel subfamily C member 6