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Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2) ELISA Kits

The protein encoded by TRPM2 is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. Additionally we are shipping TRPM2 Antibodies (50) and TRPM2 Proteins (6) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human TRPM2 TRPM2 7226 O94759
Anti-Mouse TRPM2 TRPM2 28240  
Anti-Rat TRPM2 TRPM2 294329  
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More ELISA Kits for TRPM2 Interaction Partners

Pig (Porcine) Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2) interaction partners

  1. Study determined the sequence of pig TRPC1 and TRPC3-7 channels and found pig TRPC cDNAs resemble their human homologs more than the others .

  2. heteromeric cation channels comprised of the TRPP2 mutant and the TRPC3 (show TRPC3 ELISA Kits) or TRPC7 protein induce enhanced receptor-activated Ca(2 (show CA2 ELISA Kits)+) influx that may lead to dysregulated cell growth in ADPKD

Human Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2) interaction partners

  1. This is expected to provide a basis for inhibiting TRPM2 (show CLU ELISA Kits) for the improved treatment of breast cancer, which potentially includes treating breast tumors that are resistant to chemotherapy due to their evasion of apoptosis.

  2. In a transgenic mouse model of Alzheimer's disease, TRPM2 (show CLU ELISA Kits) was involved in neuronal toxicity and memory impairment.

  3. These findings shed new light on the evolution of TRPM2 (show CLU ELISA Kits) and establish nvTRPM2 as a promising tool to decipher its complex gating mechanisms.

  4. we report here a novel effect promoted by TRPM2 (show CLU ELISA Kits), where it functions to minimize DNA damage and thus may have a role in the protection of genomic DNA in breast cancer cells.

  5. The HDACi-elicited upregulation of TRPM2 (show CLU ELISA Kits) expression.

  6. TRPM2 actively regulates the phosphorylation of GSK-3 in the brain.

  7. The degradation of zonula occludens-1 (ZO-1 (show TJP1 ELISA Kits)), and claudin-2 (show CLDN2 ELISA Kits) exhibited a great dependence on the activation of the transient receptor potential melastatin (show TRPM1 ELISA Kits) (TRPM) 2 (show CLU ELISA Kits) channel, phospholipase Cgamma1 (PLCgamma1 (show PLCG1 ELISA Kits)) and the protein kinase (show CDK7 ELISA Kits) Calpha (show PRKACA ELISA Kits) (PKCalpha (show PKCa ELISA Kits)) signaling cascade.

  8. Although further analyses are needed to clarify the mechanism underlying TRPM2 (show CLU ELISA Kits)-mediated insulin (show INS ELISA Kits) secretion, TRPM2 (show CLU ELISA Kits) could be a key player in the regulation of insulin (show INS ELISA Kits) secretion and could represent a new target for diabetes therapy

  9. TRPM2 (show CLU ELISA Kits)-AS knockdown led to prostate cancer apoptosis, with a transcriptional profile indicating an increase in cellular stress, which was coupled to cell cycle arrest, an increase in intracellular hydrogen peroxide and activation of the sense TRPM2 (show CLU ELISA Kits) gene.

  10. VEGF-induced angiogenesis required reactive oxygen species generation in endothelial cells and resultant TRPM2 activation.

Mouse (Murine) Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2) interaction partners

  1. TRPM2 activation is likely to be mediated by ADP-ribose production via PARP (show PARP1 ELISA Kits) pathway

  2. mice in which TRPM2 had been genetically deleted showed a striking deficit in their sensation of non-noxious warm temperatures, consistent with the idea that TRPM2 initiates a 'warm' signal which drives cool-seeking behaviour

  3. findings provide compelling evidence that F. tularensis catalase (show CAT ELISA Kits) restricts reactive oxygen species to temper macrophage TRPM2-mediated Ca(2 (show CA2 ELISA Kits)+) signaling and limit host immune function.

  4. TRPM2 plays roles in a wide range of pathological pain models based on peripheral and central neuroinflammation, rather than physiological nociceptive pain.

  5. The findings provide evidence for a mechanism by which Abeta (show APP ELISA Kits) impairs neurovascular regulation and suggest that TRPM2 channels are a potential therapeutic target to counteract cerebrovascular dysfunction in Alzheimer's dementia.

  6. Neointimal hyperplasia was substantially reduced in Trpm2 knockout mice.

  7. endogenous redox signals in pancreatic beta cells elevate insulin (show INS ELISA Kits) secretion via TRPM2 sensitization and activity at body temperature

  8. These results provide the first evidence to show a critical role for TRPM2 channel activation during reperfusion in the delayed increase in the [Zn(2+)]c and CA1 (show CA1 ELISA Kits) pyramidal neuronal death.

  9. Postischemic neovascularization in mice required reactive oxygen species generation in endothelial cells and resultant TRPM2 activation.

  10. neurons from the brain of Trpm2-deficient mice have significantly longer neurites with a greater number of spines.

TRPM2 Antigen Profile

Antigen Summary

The protein encoded by this gene is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.

Gene names and symbols associated with TRPM2

  • transient receptor potential cation channel, subfamily M, member 2 (TRPM2) antibody
  • transient receptor potential cation channel, subfamily M, member 2 (trpm2) antibody
  • transient receptor potential cation channel, subfamily M, member 2 (Trpm2) antibody
  • 9830168K16Rik antibody
  • C79133 antibody
  • EREG1 antibody
  • KNP3 antibody
  • LTRPC2 antibody
  • NUDT9H antibody
  • NUDT9L1 antibody
  • si:ch73-263b18.1 antibody
  • Trp7 antibody
  • TRPC7 antibody
  • TRPM2 antibody
  • Trpm2-predicted antibody
  • Trrp7 antibody

Protein level used designations for TRPM2

transient receptor potential cation channel, subfamily M, member 2 , transient receptor potential cation channel, subfamily C, member 7 , transient receptor potential cation channel, subfamily C, member 7-like , short transient receptor potential channel 7-like , transient receptor potential cation channel subfamily M member 2-like , transient receptor potential channel subfamily C member 7 , LTrpC-2 , estrogen-responsive element-associated gene 1 protein , long transient receptor potential channel 2 , transient receptor potential cation channel subfamily M member 2 , transient receptor potential channel 7 , transient receptor protein 7 , transient receptor potential melastatin family 2

GENE ID SPECIES
424835 Gallus gallus
470101 Pan troglodytes
703611 Macaca mulatta
799412 Danio rerio
100056810 Equus caballus
100083361 Ornithorhynchus anatinus
100124999 Xenopus (Silurana) tropicalis
100341596 Oryctolagus cuniculus
100443123 Pongo abelii
100479298 Ailuropoda melanoleuca
100479364 Ailuropoda melanoleuca
100539776 Meleagris gallopavo
100556895 Anolis carolinensis
100271727 Sus scrofa
7226 Homo sapiens
28240 Mus musculus
294329 Rattus norvegicus
508029 Bos taurus
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