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Transient Receptor Potential Cation Channel, Subfamily M, Member 2 Proteins (TRPM2)

The protein encoded by TRPM2 is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. Additionally we are shipping TRPM2 Antibodies (68) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TRPM2 7226 O94759
TRPM2 28240  
Rat TRPM2 TRPM2 294329  
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Top TRPM2 Proteins at antibodies-online.com

Showing 4 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 69 to 74 Days
$9,050.32
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 69 to 74 Days
$12,906.52
Details

TRPM2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine) ,
,

More Proteins for Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2) Interaction Partners

Pig (Porcine) Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2) interaction partners

  1. Study determined the sequence of pig TRPC1 and TRPC3-7 channels and found pig TRPC cDNAs resemble their human homologs more than the others .

  2. heteromeric cation channels comprised of the TRPP2 mutant and the TRPC3 (show TRPC3 Proteins) or TRPC7 protein induce enhanced receptor-activated Ca(2 (show CA2 Proteins)+) influx that may lead to dysregulated cell growth in ADPKD

Human Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2) interaction partners

  1. This is expected to provide a basis for inhibiting TRPM2 (show CLU Proteins) for the improved treatment of breast cancer, which potentially includes treating breast tumors that are resistant to chemotherapy due to their evasion of apoptosis.

  2. In a transgenic mouse model of Alzheimer's disease, TRPM2 (show CLU Proteins) was involved in neuronal toxicity and memory impairment.

  3. These findings shed new light on the evolution of TRPM2 (show CLU Proteins) and establish nvTRPM2 as a promising tool to decipher its complex gating mechanisms.

  4. we report here a novel effect promoted by TRPM2 (show CLU Proteins), where it functions to minimize DNA damage and thus may have a role in the protection of genomic DNA in breast cancer cells.

  5. The HDACi-elicited upregulation of TRPM2 (show CLU Proteins) expression.

  6. TRPM2 actively regulates the phosphorylation of GSK-3 in the brain.

  7. The degradation of zonula occludens-1 (ZO-1 (show TJP1 Proteins)), and claudin-2 (show CLDN2 Proteins) exhibited a great dependence on the activation of the transient receptor potential melastatin (show TRPM1 Proteins) (TRPM) 2 (show CLU Proteins) channel, phospholipase Cgamma1 (PLCgamma1 (show PLCG1 Proteins)) and the protein kinase (show CDK7 Proteins) Calpha (show PRKACA Proteins) (PKCalpha (show PKCa Proteins)) signaling cascade.

  8. Although further analyses are needed to clarify the mechanism underlying TRPM2 (show CLU Proteins)-mediated insulin (show INS Proteins) secretion, TRPM2 (show CLU Proteins) could be a key player in the regulation of insulin (show INS Proteins) secretion and could represent a new target for diabetes therapy

  9. TRPM2 (show CLU Proteins)-AS knockdown led to prostate cancer apoptosis, with a transcriptional profile indicating an increase in cellular stress, which was coupled to cell cycle arrest, an increase in intracellular hydrogen peroxide and activation of the sense TRPM2 (show CLU Proteins) gene.

  10. VEGF-induced angiogenesis required reactive oxygen species generation in endothelial cells and resultant TRPM2 activation.

Mouse (Murine) Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2) interaction partners

  1. TRPM2 activation is likely to be mediated by ADP-ribose production via PARP (show PARP1 Proteins) pathway

  2. mice in which TRPM2 had been genetically deleted showed a striking deficit in their sensation of non-noxious warm temperatures, consistent with the idea that TRPM2 initiates a 'warm' signal which drives cool-seeking behaviour

  3. findings provide compelling evidence that F. tularensis catalase (show CAT Proteins) restricts reactive oxygen species to temper macrophage TRPM2-mediated Ca(2 (show CA2 Proteins)+) signaling and limit host immune function.

  4. TRPM2 plays roles in a wide range of pathological pain models based on peripheral and central neuroinflammation, rather than physiological nociceptive pain.

  5. The findings provide evidence for a mechanism by which Abeta (show APP Proteins) impairs neurovascular regulation and suggest that TRPM2 channels are a potential therapeutic target to counteract cerebrovascular dysfunction in Alzheimer's dementia.

  6. Neointimal hyperplasia was substantially reduced in Trpm2 knockout mice.

  7. endogenous redox signals in pancreatic beta cells elevate insulin (show INS Proteins) secretion via TRPM2 sensitization and activity at body temperature

  8. These results provide the first evidence to show a critical role for TRPM2 channel activation during reperfusion in the delayed increase in the [Zn(2+)]c and CA1 (show CA1 Proteins) pyramidal neuronal death.

  9. Postischemic neovascularization in mice required reactive oxygen species generation in endothelial cells and resultant TRPM2 activation.

  10. neurons from the brain of Trpm2-deficient mice have significantly longer neurites with a greater number of spines.

TRPM2 Protein Profile

Protein Summary

The protein encoded by this gene is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.

Gene names and symbols associated with TRPM2

  • transient receptor potential cation channel, subfamily M, member 2 (TRPM2)
  • transient receptor potential cation channel, subfamily M, member 2 (trpm2)
  • transient receptor potential cation channel, subfamily M, member 2 (Trpm2)
  • 9830168K16Rik protein
  • C79133 protein
  • EREG1 protein
  • KNP3 protein
  • LTRPC2 protein
  • NUDT9H protein
  • NUDT9L1 protein
  • si:ch73-263b18.1 protein
  • Trp7 protein
  • TRPC7 protein
  • TRPM2 protein
  • Trpm2-predicted protein
  • Trrp7 protein

Protein level used designations for TRPM2

transient receptor potential cation channel, subfamily M, member 2 , transient receptor potential cation channel, subfamily C, member 7 , transient receptor potential cation channel, subfamily C, member 7-like , short transient receptor potential channel 7-like , transient receptor potential cation channel subfamily M member 2-like , transient receptor potential channel subfamily C member 7 , LTrpC-2 , estrogen-responsive element-associated gene 1 protein , long transient receptor potential channel 2 , transient receptor potential cation channel subfamily M member 2 , transient receptor potential channel 7 , transient receptor protein 7 , transient receptor potential melastatin family 2

GENE ID SPECIES
424835 Gallus gallus
470101 Pan troglodytes
703611 Macaca mulatta
799412 Danio rerio
100056810 Equus caballus
100083361 Ornithorhynchus anatinus
100124999 Xenopus (Silurana) tropicalis
100341596 Oryctolagus cuniculus
100443123 Pongo abelii
100479298 Ailuropoda melanoleuca
100479364 Ailuropoda melanoleuca
100539776 Meleagris gallopavo
100556895 Anolis carolinensis
100271727 Sus scrofa
7226 Homo sapiens
28240 Mus musculus
294329 Rattus norvegicus
508029 Bos taurus
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