Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2) ELISA Kits

The protein encoded by TRPM2 is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. Additionally we are shipping TRPM2 Antibodies (81) and TRPM2 Proteins (6) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human TRPM2 TRPM2 7226 O94759
Anti-Mouse TRPM2 TRPM2 28240  
Anti-Rat TRPM2 TRPM2 294329  
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More ELISA Kits for TRPM2 Interaction Partners

Pig (Porcine) Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2) interaction partners

  1. Study determined the sequence of pig TRPC1 and TRPC3-7 channels and found pig TRPC cDNAs resemble their human homologs more than the others .

  2. heteromeric cation channels comprised of the TRPP2 mutant and the TRPC3 (show TRPC3 ELISA Kits) or TRPC7 protein induce enhanced receptor-activated Ca(2 (show CA2 ELISA Kits)+) influx that may lead to dysregulated cell growth in ADPKD

Human Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2) interaction partners

  1. The work summarized here shows that TRPM2 (show CLU ELISA Kits) channels protect cardiac myocytes from ischaemia-reperfusion injury and tumour cells from doxorubicin toxicity, and demonstrates that the mechanisms involve preservation of mitochondrial bioenergetics and modulation of ROS (show ROS1 ELISA Kits)

  2. Activation of TRPM2 (show CLU ELISA Kits) channels, however, caused intracellular release of not only Ca(2 (show CA2 ELISA Kits)+) but also of Zn(2+) Intriguingly, elevation of intracellular Zn(2+) faithfully reproduced all of the effects of H2O2, whereas Ca(2 (show CA2 ELISA Kits)+) showed opposite effects. Interestingly, H2O2 caused increased trafficking of Zn(2+)-enriched lysosomes to the leading edge of migrating cells, presumably to impart polarisation of Zn(2+) location.

  3. neutrophils sense reactive oxygen species via the TRPM2 (show CLU ELISA Kits) channel to arrest migration at their target site.

  4. The inhibitory function of oxidant sensing by TRPM2 (show CLU ELISA Kits) requires the oxidation of Cys549, which then induces TRMP2 binding to formyl peptide receptor 1 (FPR1 (show FPR1 ELISA Kits)) and subsequent FPR1 (show FPR1 ELISA Kits) internalization and signaling inhibition

  5. findings demonstrate the important function of TRPM2 (show CLU ELISA Kits) in modulation of cell survival through mitochondrial ROS (show ROS1 ELISA Kits), and the potential of targeted inhibition of TRPM2 (show CLU ELISA Kits) as a therapeutic approach to reduce cellular bioenergetics, tumor growth, and enhance susceptibility to chemotherapeutic agents.

  6. Study demonstrate that PRL is necessary for the survival of (retinal pigment epithelium) RPE under normal and advancing age conditions and, identified SIRT2 and TRPM2 as molecular targets for the antioxidant and antiapoptotic actions of PRL in the RPE.

  7. TRPM2 (show CLU ELISA Kits) has a role in the DNA damage response of T cell leukemia cells in a BCL-2 (show BCL2 ELISA Kits) dependent manner

  8. Data show that HEK293 cells expressing low levels of receptor potential melastatin 2 (TRPM2) chan (show TRPM3 ELISA Kits)nel wer (show CLU ELISA Kits)e more susceptible to silica nanoparticles (NPs) than those expressing high levels of TRPM2.

  9. This is expected to provide a basis for inhibiting TRPM2 (show CLU ELISA Kits) for the improved treatment of breast cancer, which potentially includes treating breast tumors that are resistant to chemotherapy due to their evasion of apoptosis.

  10. In a transgenic mouse model of Alzheimer's disease, TRPM2 (show CLU ELISA Kits) was involved in neuronal toxicity and memory impairment.

Mouse (Murine) Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2) interaction partners

  1. These findings of this study suggest that TRPM2 channels play an essential role in mediating hypoxic-ischemic brain injury in neonatal mice.

  2. TRPM2 regulates phagosomal acidification, and is essential for the bacterial killing function of macrophages.

  3. Lysophosphatidylcholine induces intracellular Ca(2 (show CA2 ELISA Kits)+) influx and increases phosphorylation of p38 MAPK (show MAPK14 ELISA Kits) via TRPM2, which in turn activates microglia.

  4. The current study demonstrated that a physiological concentration of adrenaline attenuates insulin (show INS ELISA Kits) release via coupling of alpha2A-adrenoceptor to cAMP/TRPM2 signaling.

  5. Trpm2 does not seem to play a major role in myeloid leukemogenesis. Additionally, loss of Trpm2 does not augment the cytotoxicity of standard AML (show RUNX1 ELISA Kits) chemotherapeutic agents.

  6. TRPM2 channels contribute to visceral nociception in response to noxious stimuli under normal conditions and visceral hypersensitivity in pathological conditions.

  7. Data show that macrophages from young mice showed lower transient receptor potential melastatin 2 (show TRPM3 ELISA Kits) (TRPM2) expression than those from senescent mice and had lower viability after silica nanoparticles (NPs (show NPS ELISA Kits)) exposure than those from senescent ones.

  8. TRPM2 activation is likely to be mediated by ADP-ribose production via PARP (show PARP1 ELISA Kits) pathway

  9. mice in which TRPM2 had been genetically deleted showed a striking deficit in their sensation of non-noxious warm temperatures, consistent with the idea that TRPM2 initiates a 'warm' signal which drives cool-seeking behaviour

  10. findings provide compelling evidence that F. tularensis catalase (show CAT ELISA Kits) restricts reactive oxygen species to temper macrophage TRPM2-mediated Ca(2 (show CA2 ELISA Kits)+) signaling and limit host immune function.

TRPM2 Antigen Profile

Antigen Summary

The protein encoded by this gene is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.

Gene names and symbols associated with TRPM2

  • transient receptor potential cation channel, subfamily M, member 2 (TRPM2) antibody
  • transient receptor potential cation channel, subfamily M, member 2 (trpm2) antibody
  • transient receptor potential cation channel, subfamily M, member 2 (Trpm2) antibody
  • 9830168K16Rik antibody
  • C79133 antibody
  • EREG1 antibody
  • KNP3 antibody
  • LTRPC2 antibody
  • NUDT9H antibody
  • NUDT9L1 antibody
  • si:ch73-263b18.1 antibody
  • Trp7 antibody
  • TRPC7 antibody
  • TRPM2 antibody
  • Trpm2-predicted antibody
  • Trrp7 antibody

Protein level used designations for TRPM2

transient receptor potential cation channel, subfamily M, member 2 , transient receptor potential cation channel, subfamily C, member 7 , transient receptor potential cation channel, subfamily C, member 7-like , short transient receptor potential channel 7-like , transient receptor potential cation channel subfamily M member 2-like , transient receptor potential channel subfamily C member 7 , LTrpC-2 , estrogen-responsive element-associated gene 1 protein , long transient receptor potential channel 2 , transient receptor potential cation channel subfamily M member 2 , transient receptor potential channel 7 , transient receptor protein 7 , transient receptor potential melastatin family 2

GENE ID SPECIES
424835 Gallus gallus
470101 Pan troglodytes
703611 Macaca mulatta
799412 Danio rerio
100056810 Equus caballus
100083361 Ornithorhynchus anatinus
100124999 Xenopus (Silurana) tropicalis
100341596 Oryctolagus cuniculus
100443123 Pongo abelii
100479298 Ailuropoda melanoleuca
100479364 Ailuropoda melanoleuca
100539776 Meleagris gallopavo
100556895 Anolis carolinensis
100271727 Sus scrofa
7226 Homo sapiens
28240 Mus musculus
294329 Rattus norvegicus
508029 Bos taurus
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