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TRPM6 is predominantly expressed in the kidney and colon, and encodes a protein containing an ion channel domain and a protein kinase domain. Additionally we are shipping TRPM6 Antibodies (44) and TRPM6 Kits (3) and many more products for this protein.
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Data show that resistant cells express lower amounts of the transient receptor potential cation channel (show TRPV1 Proteins) subfamily M TRPM6 and 7, both involved in magnesium transport.
The Different Roles of The Channel-Kinases TRPM6 and TRPM7 (show TRPM7 Proteins)
we showed that two serum magnesium associated loci, MUC1 (show MUC1 Proteins) and TRPM6, had significant effect modification with progestin use and insulin (show INS Proteins) levels, respectively, in European Americans.
N-Myc (show MYCN Proteins) can promote neuroblastoma (show ARHGEF16 Proteins) cell proliferation through up-regulation of the channel kinases TRPM6 and TRPM7 (show TRPM7 Proteins)
TRPM6 mRNA and protein levels in atrial fibrillation group were elevated markedly in comparison with sinus rhythm group.
Knowledge of TRPM6 functioning is of vital importance to decipher its role in Mg handling and will, in particular, provide a molecular basis for achieving a better understanding of Mg mal (show MAL Proteins)(re)absorption and hence systemic Mg balance.
Data indicate heteromer formation between channel kinases TRPM6 and TRPM7 (show TRPM7 Proteins) influences the biological activity of the ion channels.
We conclude that the new TRPM6 missense mutations lead to dysregulated intestinal/renal Mg(2 (show MUC7 Proteins)+) (re)absorption as a consequence of loss of TRPM6 channel function.
TRPM6 kinase activity is linked to channel activity through a kinase-independent mechanism involving the dimerization motif binding to a pocket within the kinase domain.
TRPM6 modulates the functionality of TRPM7 (show TRPM7 Proteins), and the TRPM6 kinase plays a critical role in tuning the phenotype of the TRPM7 (show TRPM7 Proteins).M6 channel complex.
in a model of inherited hypomagnesemia, TRPM6 and TRPM7 (show TRPM7 Proteins), but not paracellin-1 (show CLDN16 Proteins), are downregulated
TRPM6 deletion is embryonic lethal in mice; Heterozygous deletion of TRPM6 results in a mild hypomagnesemia
consistently reduced expression of TRPM6 mRNA may play a role in the pathogenesis of hypomagnesemia in C57BL/6 asthmatic mice.
MsrB1 (show SEPX1 Proteins) recovers TRPM6 channel activity by reducing the oxidation of Met(1755) and could, thereby, function as a modulator of TRPM6 during oxidative stress.
Trpm6(-/-) mice almost never survived to weaning and show neural tube defects.
In C57BL/6J mice, dietary Mg(2 (show MCOLN1 Proteins)+)-restriction results in increased Mg(2 (show MCOLN1 Proteins)+) (re)absorption, which is correlated with increased TRPM6 expression.
REA (show PHB2 Proteins) operates as a negative feedback modulator of TRPM6 in the regulation of active Mg(2 (show MCOLN1 Proteins)+) (re)absorption and provides new insight into the molecular mechanism of renal transepithelial Mg(2 (show MCOLN1 Proteins)+) transport.
Modulation of TRPM6 and Na(+)/Mg(2 (show MCOLN1 Proteins)+) exchange in mammary epithelial cells in response to variations of magnesium availability.
This gene is predominantly expressed in the kidney and colon, and encodes a protein containing an ion channel domain and a protein kinase domain. It is crucial for magnesium homeostasis, and plays an essential role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Mutations in this gene are associated with hypomagnesemia with secondary hypocalcemia. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
transient receptor potential cation channel, subfamily M, member 6
, channel kinase 2
, melastatin-related TRP cation channel 6
, transient receptor potential cation channel subfamily M member 6
, transient receptor potential cation channel 6/channel-kinase 2