Transient Receptor Potential Cation Channel, Subfamily M, Member 6 Proteins (TRPM6)

TRPM6 is predominantly expressed in the kidney and colon, and encodes a protein containing an ion channel domain and a protein kinase domain. Additionally we are shipping TRPM6 Antibodies (47) and TRPM6 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TRPM6 140803 Q9BX84
TRPM6 225997 Q8CIR4
Rat TRPM6 TRPM6 293874  
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Top TRPM6 Proteins at antibodies-online.com

Showing 2 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
Details

TRPM6 Proteins by Origin and Source

Origin Expressed in Conjugate
Human

Mouse (Murine)

More Proteins for Transient Receptor Potential Cation Channel, Subfamily M, Member 6 (TRPM6) Interaction Partners

Human Transient Receptor Potential Cation Channel, Subfamily M, Member 6 (TRPM6) interaction partners

  1. Results found that the haplotype containing two common TRPM6 SNPs (rs3750425 and rs2274924) increases the risk for proton pump inhibitor-induced hypomagnesemia.

  2. TNF-alpha (show TNF Proteins) rescues the EGFR (show EGFR Proteins) tyrosine kinase (show TXK Proteins) inhibitor-induced decrease in TRPM6 expression and Mg2 (show MUC7 Proteins)+ influx mediated via the activation of an NF-kappaB (show NFKB1 Proteins) signaling pathway.

  3. A homozygous frame-shift mutation in the TRPM6 gene is associated with Hereditary hypomagnesemia with secondary hypocalcemia.

  4. Data show that resistant cells express lower amounts of the transient receptor potential cation channel (show TRPV1 Proteins) subfamily M TRPM6 and 7, both involved in magnesium transport.

  5. The Different Roles of The Channel-Kinases TRPM6 and TRPM7 (show TRPM7 Proteins)

  6. we showed that two serum magnesium associated loci, MUC1 (show MUC1 Proteins) and TRPM6, had significant effect modification with progestin use and insulin (show INS Proteins) levels, respectively, in European Americans.

  7. N-Myc (show MYCN Proteins) can promote neuroblastoma (show ARHGEF16 Proteins) cell proliferation through up-regulation of the channel kinases TRPM6 and TRPM7 (show TRPM7 Proteins)

  8. TRPM6 mRNA and protein levels in atrial fibrillation group were elevated markedly in comparison with sinus rhythm group.

  9. Knowledge of TRPM6 functioning is of vital importance to decipher its role in Mg handling and will, in particular, provide a molecular basis for achieving a better understanding of Mg mal(re)absorption and hence systemic Mg balance.

  10. Data indicate heteromer formation between channel kinases TRPM6 and TRPM7 (show TRPM7 Proteins) influences the biological activity of the ion channels.

Mouse (Murine) Transient Receptor Potential Cation Channel, Subfamily M, Member 6 (TRPM6) interaction partners

  1. Hence, maintenance of organismal Mg(2 (show MCOLN1 Proteins)+) balance by TRPM6 is crucial for prenatal development and survival to adulthood.

  2. TRPM6 mRNA increased during the last 4 days of pregnancy, coinciding with fetal bone mineralization in mice. TRPM6 mRNA and protein was localized in the trophoblasts in labyrinth where the maternal-fetal Ca(2 (show CA2 Proteins)+) transport occurs. In patch-clamp recordings, we observed TRPM6/TRPM7 (show TRPM7 Proteins)-like currents in mouse trophoblasts after starting fetal bone mineralization but not before mineralization.

  3. in a model of inherited hypomagnesemia, TRPM6 and TRPM7 (show TRPM7 Proteins), but not paracellin-1 (show CLDN16 Proteins), are downregulated

  4. TRPM6 deletion is embryonic lethal in mice; Heterozygous deletion of TRPM6 results in a mild hypomagnesemia

  5. consistently reduced expression of TRPM6 mRNA may play a role in the pathogenesis of hypomagnesemia in C57BL/6 asthmatic mice.

  6. MsrB1 (show SEPX1 Proteins) recovers TRPM6 channel activity by reducing the oxidation of Met(1755) and could, thereby, function as a modulator of TRPM6 during oxidative stress.

  7. Trpm6(-/-) mice almost never survived to weaning and show neural tube defects.

  8. In C57BL/6J mice, dietary Mg(2 (show MCOLN1 Proteins)+)-restriction results in increased Mg(2 (show MCOLN1 Proteins)+) (re)absorption, which is correlated with increased TRPM6 expression.

  9. REA (show PHB2 Proteins) operates as a negative feedback modulator of TRPM6 in the regulation of active Mg(2 (show MCOLN1 Proteins)+) (re)absorption and provides new insight into the molecular mechanism of renal transepithelial Mg(2 (show MCOLN1 Proteins)+) transport.

  10. Modulation of TRPM6 and Na(+)/Mg(2 (show MCOLN1 Proteins)+) exchange in mammary epithelial cells in response to variations of magnesium availability.

TRPM6 Protein Profile

Protein Summary

This gene is predominantly expressed in the kidney and colon, and encodes a protein containing an ion channel domain and a protein kinase domain. It is crucial for magnesium homeostasis, and plays an essential role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Mutations in this gene are associated with hypomagnesemia with secondary hypocalcemia. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Gene names and symbols associated with TRPM6

  • transient receptor potential cation channel, subfamily M, member 6 (TRPM6)
  • transient receptor potential cation channel, subfamily M, member 6 (Trpm6)
  • CHAK2 protein
  • HMGX protein
  • HOMG protein
  • HOMG1 protein
  • HSH protein
  • TRPM6 protein
  • TRPM6/CHAK2 protein

Protein level used designations for TRPM6

transient receptor potential cation channel, subfamily M, member 6 , channel kinase 2 , melastatin-related TRP cation channel 6 , transient receptor potential cation channel subfamily M member 6 , transient receptor potential cation channel 6/channel-kinase 2

GENE ID SPECIES
527597 Bos taurus
472957 Pan troglodytes
484163 Canis lupus familiaris
706119 Macaca mulatta
140803 Homo sapiens
225997 Mus musculus
293874 Rattus norvegicus
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