Transient Receptor Potential Cation Channel, Subfamily M, Member 7 Proteins (TRPM7)

The protein encoded by TRPM7 is both an ion channel and a serine/threonine protein kinase. Additionally we are shipping TRPM7 Antibodies (175) and TRPM7 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TRPM7 54822 Q96QT4
TRPM7 58800 Q923J1
TRPM7 679906  
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Top TRPM7 Proteins at antibodies-online.com

Showing 5 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
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Insect Cells Human GST tag   5 μg Log in to see 11 to 12 Days
$560.00
Details
HOST_Escherichia coli (E. coli) Rat T7 tag,His tag   100 μg Log in to see 15 to 18 Days
$720.00
Details

TRPM7 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for Transient Receptor Potential Cation Channel, Subfamily M, Member 7 (TRPM7) Interaction Partners

Zebrafish Transient Receptor Potential Cation Channel, Subfamily M, Member 7 (TRPM7) interaction partners

  1. tct may represent a novel as well as selective regulator of melanoblast development within the neural crest lineage.

  2. Abnormal differentiation of dopaminergic neurons in zebrafish trpm7 mutant larvae impairs development of the motor pattern.

  3. TRPM7 plays a role within sensory neurons in modulating neutrotransmitter release at central synapses, similar to the role proprosed for mammalian TRPM7 at peripheral synapses.

  4. Trpm7 regulates exocrine pancreatic development via the Mg(2 (show MCOLN1 Proteins)+)-sensitive Socs3a (show SOCS3 Proteins) pathway.

  5. This study showed that stanniocalcin 1 (stc1 (show STC1 Proteins))modulates cation levels in trpm7 mutants and in the wild type; levels of cations are restored to normal in trpm7 mutants when stc1 (show STC1 Proteins) activity is blocked.

  6. Mutation in trpm7 leads to defective skeletogenesis and kidney stone formation.

  7. Cell death of melanophores in zebrafish trpm7 mutant embryos depends on melanin synthesis.

Human Transient Receptor Potential Cation Channel, Subfamily M, Member 7 (TRPM7) interaction partners

  1. Our results show that the activating TRPM7 channel may prevent AD-related Abeta (show APP Proteins) neuropathology via modulating Ca(2 (show CA2 Proteins)+)-regulated basal autophagy.

  2. The results suggest that TRPM7 is required for proliferation, migration and invasion of ovarian cancer cells through regulating multiple signaling transduction pathways and the formation of focal adhesions.

  3. The melastatin (show TRPM1 Proteins)-like transient receptor potential cation channel (show TRPV1 Proteins), subfamily M, member 7 (TRPM7), which is responsible for Mg(2 (show MUC7 Proteins)+) entry, was studies and [Mg(2 (show MUC7 Proteins)+)]i measured in cells stably expressing wildtype CFTR (show CFTR Proteins), and two mutant proteins (DeltaF508-CFTR (show CFTR Proteins) and G551D-CFTR (show CFTR Proteins)). This study shows for the first time that [Mg(2 (show MUC7 Proteins)+)]i is decreased in cells expressing DeltaF508-CFTR (show CFTR Proteins) and G551D-CFTR (show CFTR Proteins) mutated proteins.

  4. Variability of the TRPM7 current density in human cardiomyocytes is related to the clinical history, being higher in atrial fibrillation and in ischemic cardiomyopathy.

  5. our results show that TRPM7 is involved in PDAC cell invasion through regulation of Hsp90alpha (show HSP90AA2 Proteins)/uPA (show PRAP1 Proteins)/MMP-2 (show MMP2 Proteins) proteolytic axis, confirming that this channel could be a promising biomarker and possibly a target for PDAC metastasis therapy.

  6. Data show that activated TRPM7 activity contributes to the devastating migratory and invasive characteristics of glioblastoma (GBM) .

  7. Bradykinin promoted migration and invasion of hepatocellular carcinoma cells through TRPM7 and MMP2 (show MMP2 Proteins).

  8. chronic aldosterone treatment increases the plasma membrane expression of TRPM7, which is associated with an increase of TRPM7 current. This process occurs via an MR-dependent, genomic signaling cascade involving SGK1 (show SGK1 Proteins) and a functioning TRPM7 alpha-kinase domain.

  9. expression of TRPM7 has an impact on the prognosis of patients with esophageal squamous cell carcinoma

  10. TRPM7 is part of a large cytoskeletal complex that may affect the malignant potential of tumor cells by regulating actomyosin dynamics and cell-matrix interactions.

Mouse (Murine) Transient Receptor Potential Cation Channel, Subfamily M, Member 7 (TRPM7) interaction partners

  1. TRPM7 kinase activity regulates mast cell degranulation by changing its sensitivity to intracellular calcium.

  2. TRPM7 is part of a large cytoskeletal complex that may affect the malignant potential of tumor cells by regulating actomyosin dynamics and cell-matrix interactions.

  3. Inhibition of TRPM7 reduces calcium influx and accelerates the polarization of hippocampal neurons.

  4. our results suggest the differential roles of TRPM7 in endochondral and intramembranous ossification.

  5. TRPM7 dysfunction may cause macrothrombocytopenia in humans and mice.

  6. TRPM7 kinase is a novel player in Angiotensin II induced hypertension and vascular and target organ damage.

  7. Immature intercellular junctions in Trpm7 knock-out mice might lead to a disruption of barrier function resulting in inflammation and hypersensitive bladder afferent nerves that may affect voiding behavior in vivo

  8. By inhibiting TRPM7 and ANO1 (show ANO1 Proteins) via opioid receptor signaling pathways.

  9. Abolishing TRPM7 kinase activity does not impair its channel activity and kinase activity is not essential for regulation of mammalian Mg(2 (show MCOLN1 Proteins)+) homeostasis.

  10. results suggest that TRPM7 kinase is a sensor of magnesium status and provides coordination of cellular and systemic responses to magnesium deprivation.

TRPM7 Protein Profile

Protein Summary

The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam.

Gene names and symbols associated with TRPM7

  • transient receptor potential cation channel, subfamily M, member 7 (TRPM7)
  • transient receptor potential cation channel, subfamily M, member 7 (trpm7)
  • transient receptor potential cation channel, subfamily M, member 7 (Trpm7)
  • 2310022G15Rik protein
  • 4833414K03Rik protein
  • 5033407O22Rik protein
  • ALSPDC protein
  • cb495 protein
  • Chak protein
  • CHAK1 protein
  • Ltpr7 protein
  • LTrpC-7 protein
  • Ltrpc7 protein
  • Trp-plik protein
  • TRPM7 protein
  • TRPPLIK protein

Protein level used designations for TRPM7

transient receptor potential cation channel subfamily M member 7 , nutria , tct , touchtone , transient receptor potential melastatin 7 , transient receptor potential cation channel, subfamily M, member 7 , LTRPC ion channel family member 7 , LTrpC-7 , channel-kinase 1 , long transient receptor potential channel 7 , transient receptor potential-phospholipase C-interacting kinase , transient receptor potential M7 , transient receptor potential-related protein, ChaK

GENE ID SPECIES
427502 Gallus gallus
514642 Bos taurus
100034101 Equus caballus
280653 Danio rerio
100037693 Ovis aries
100228325 Taeniopygia guttata
100499162 Xenopus laevis
54822 Homo sapiens
478300 Canis lupus familiaris
58800 Mus musculus
679906 Rattus norvegicus
100169932 Sus scrofa
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