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Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Additionally we are shipping TRPM8 Proteins (9) and TRPM8 Kits (2) and many more products for this protein.
Showing 10 out of 132 products:
Human Polyclonal TRPM8 Primary Antibody for EIA, IHC (p) - ABIN955342
Yee, Zhou, Lee: Transient receptor potential channel TRPM8 is over-expressed and required for cellular proliferation in pancreatic adenocarcinoma. in Cancer letters 2010
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Human Polyclonal TRPM8 Primary Antibody for EIA, IF - ABIN955341
Kühn, Witschas, Kühn, Lückhoff: Contribution of the S5-pore-S6 domain to the gating characteristics of the cation channels TRPM2 and TRPM8. in The Journal of biological chemistry 2010
Show all 5 references for ABIN955341
Human Polyclonal TRPM8 Primary Antibody for EIA, IHC (p) - ABIN360715
Kiessling, Füssel, Schmitz, Stevanovic, Meye, Weigle, Klenk, Wirth, Rieber: Identification of an HLA-A*0201-restricted T-cell epitope derived from the prostate cancer-associated protein trp-p8. in The Prostate 2003
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Human Polyclonal TRPM8 Primary Antibody for EIA, IHC (p) - ABIN360716
Tsavaler, Shapero, Morkowski, Laus: Trp-p8, a novel prostate-specific gene, is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins. in Cancer research 2001
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Human Polyclonal TRPM8 Primary Antibody for IF, IHC (p) - ABIN655714
Gkika, Flourakis, Lemonnier, Prevarskaya: PSA reduces prostate cancer cell motility by stimulating TRPM8 activity and plasma membrane expression. in Oncogene 2010
Chicken Polyclonal TRPM8 Primary Antibody for IHC, WB - ABIN2776255
Wondergem, Ecay, Mahieu, Owsianik, Nilius: HGF/SF and menthol increase human glioblastoma cell calcium and migration. in Biochemical and biophysical research communications 2008
The role of TRPM8 in the Guinea-pig bladder-cooling reflex investigated using a novel TRPM8 antagonist
Study used a combination of molecular modeling and experimental techniques to examine the structure of the TRPM8 transmembrane and pore helix region including the conducting conformation of the selectivity filter
Translational and clinical investigation to exploit TRPM8 as a molecular biomarker and therapeutic target is expected to make a positive impact on precision medicine in pancreatic cancer and other malignant diseases.
Several TRPM8 variants appeared to be poorly expressed in transfected HEK293 cells compared with non-mutated TRPM8.
The GC variant of the TRPM8: c.750G > C (rs11562975) polymorphism is associated with cold-induced airway hyperresponsiveness in patients with bronchial asthma.
we found that the androgen-mediated TRPM8 channel activity is negatively regulated by the androgen receptor (show AR Antibodies) protein
TRPM8 underlines the important physiologic role of the nose in temperature regulation, both in patients with allergy and those without allergy. Isometric contraction studies demonstrate the role of TRPM8 in regulating nasal patency and airway resistance.
These results are the first to show that menthol directly binds to the TRPM8 sensing domain.
Genetic polymorphisms in TRPM8 genes modify individual susceptibility to metabolic syndrome in a Turkish population.
developed a new functional knockout mouse strain by deleting the pore domain of TRPM8 and demonstrated that eTRPM8 knockout impairs adaptation of the epidermis to low temperatures
Antibodies against TRPM8 are not found in scleroderma patient sera, suggesting that the abnormal cold sensitivity and associated abnormal vascular reactivity in scleroderma patients is not the result of an immune process targeting TRPM8.
Reduced functional expression of TRPM8 in sensory neurons (due to VAMP7 (show VAMP7 Antibodies) knockout) is associated with deficits in cold avoidance and icilin-induced cold hypersensitivity.
Report essential role of skin TRPM8 in a model of acute cold-induced urinary urgency.
This study findings suggest the existence of VGLUT2 (show SLC17A6 Antibodies) (but not VGLUT1 (show SLC17A7 Antibodies))-mediated glutamate (show GRIN1 Antibodies) signaling in TRPM8+ neurons possibly underlying the cold-induced acute pain and hypersensitivity to cold following pulpal inflammation.
Data suggest that blockage of transient receptor potential (TRP) channels TRPA1 (show TRPA1 Antibodies), TRPV4 (show TRPV4 Antibodies) and possibly TRPM8 may represent a therapeutic option for patients with colonic discomfort and pain.
TRPM8 signaling in mucosal sensory neurons is indispensable for the regulation of innate inflammatory responses via the neuropeptide CGRP (show CALCA Antibodies).
TRPM8-expressing dural afferent fibers undergo cell- and target tissue-specific axonal pruning during postnatal development.
our findings suggest that temperature response thresholds in mice are dynamic. PLC (show HSPG2 Antibodies)-mediated hydrolysis of phosphoinositol 4,5-bisphosphate modulates TRPM8 activity and thereby regulates the response thresholds to cold stimuli.
ZBTB20 (show ZBTB20 Antibodies) regulates nociception and pain sensation by modulating TRPV1 (show TRPV1 Antibodies), TRPA1 (show TRPA1 Antibodies) and TRPM8 expression in nociceptive sensory neurons.
Increased expression of TRPM8 may contribute to the visceral hyperalgesia of experimental colitis.
Study shows that oxidative stress affects urothelial function involving a TRPM8-mediated mechanism and these effects may have important implications for aging.
Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.
transient receptor potential cation channel, subfamily M, member 8
, transient receptor potential cation channel subfamily M member 8b
, transient receptor potential cation channel subfamily M member 8
, transient potential cation channel subfamily M member 8
, long transient receptor potential channel 6
, short form of the TRPM8 cationic channel
, transient receptor potential p8
, transient receptor potential subfamily M member 8
, TRP ion channel TRPM8
, transient receptor potential-p8
, cold menthol receptor 1
, cold/menthol receptor 1
, menthol receptor
, transient receptor potential M8 protein
, transient receptor potential cation channel, subfamily M, member 8 (predicted), 3 prime
, transient receptor potential cation channel, subfamily M, member 8 (predicted), 5 prime